Rv0014c - transmembrane serine/threonine-protein kinase B pknB


Protein Domains

Gene Information
LocusRv0014c
SymbolpknB
Gene Nametransmembrane serine/threonine-protein kinase B pknB
Location15590 - 17470 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:1881 bp
Protein:627 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number36628
Related GenesMAP0016c MAV_0017 Mkms_0023 ML0016 Mmcs_0015 MSMEG_0028 MT0017 MUL_0018 Mvan_0023 nfa800
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
Search for regulators of Rv0014c
Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionRegulatory Rv3223cactivesourish102012-10-05
Co-expression (Functional linkage)
T. Song, SL. Dove et al. RshA, an anti-sigma factor that regulates the activity of the mycobacterial stress response sigma factor SigH. Mol. Microbiol. 2003
InteractionRegulatory Rv3223cactivesourish102012-10-05
Co-expression (Functional linkage)
P. Sachdeva,R. Misra,AK. Tyagi,Y. Singh The sigma factors of Mycobacterium tuberculosis: regulation of the regulators. FEBS J. 2010
InteractionRegulatory Rv3223cactivesourish102012-10-05
Co-expression (Functional linkage)
T. Song, SL. Dove et al. RshA, an anti-sigma factor that regulates the activity of the mycobacterial stress response sigma factor SigH. Mol. Microbiol. 2003
InteractionRegulatory Rv3223cactivesourish102012-10-05
Co-expression (Functional linkage)
P. Sachdeva,R. Misra,AK. Tyagi,Y. Singh The sigma factors of Mycobacterium tuberculosis: regulation of the regulators. FEBS J. 2010
InteractionSignaling Rv2145cactiveharsharohiratruefriend2012-10-05
Affinity purification (Physical interaction)
authors,OW. Schonecke,W. Schüffel Evaluation of combined pharmacological and psychotherapeutic treatment in patients with functional abdominal disorders. Psychother Psychosom 1975
InteractionSignaling Rv2145cactiveharsharohiratruefriend2012-10-05
Affinity purification (Physical interaction)
authors,RJ. Smith,RG. Bryant Metal substitutions incarbonic anhydrase: a halide ion probe study. Biochem. Biophys. Res. Commun. 1975
InteractionSignaling Rv2145cactiveharsharohiratruefriend2012-10-05
Affinity purification (Physical interaction)
authors,D. Bucens,MC. Pain Influence of hematocrit, blood gas tensions, and pH on pressure-flow relations in the isolated canine lung. Circ. Res. 1975
InteractionSignaling Rv2145cactiveharsharohiratruefriend2012-10-05
Affinity purification (Physical interaction)
authors,PW. Hermans,F. Abebe,VI. Kuteyi,AH. Kolk,JE. Thole,M. Harboe Molecular and immunological characterization of the highly conserved antigen 84 from Mycobacterium tuberculosis and Mycobacterium leprae. Infect. Immun. 1995
InteractionSignaling Rv2145cactiveharsharohiratruefriend2012-10-05
Affinity purification (Physical interaction)
authors,JM. Stein The effect of adrenaline and of alpha- and beta-adrenergic blocking agents on ATP concentration and on incorporation of 32Pi into ATP in rat fat cells. Biochem. Pharmacol. 1975
InteractionSignaling Rv2145cactiveharsharohiratruefriend2012-10-05
Affinity purification (Physical interaction)
authors,H. Autrup,GP. Warwick Some characteristics of two azoreductase systems in rat liver. Relevance to the activity of 2-[4'-di(2"-bromopropyl)-aminophenylazo]benzoic acid (CB10-252), a compound possessing latent cytotoxic activity. Chem. Biol. Interact. 1975
InteractionSignaling Rv2145cactiveharsharohiratruefriend2012-10-05
Affinity purification (Physical interaction)
CM. Kang, DW. Abbott et al. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 2005
InteractionSignaling Rv2145cactiveharsharohiratruefriend2012-10-05
Affinity purification (Physical interaction)
authors,K. Hamasha,MB. Sahana,C. Jani,S. Nyayapathy,CM. Kang,SJ. Rehse The effect of Wag31 phosphorylation on the cells and the cell envelope fraction of wild-type and conditional mutants of Mycobacterium smegmatis studied by visible-wavelength Raman spectroscopy. Biochem. Biophys. Res. Commun. 2010
InteractionActivatedBy Rv1827activemadhulsbu2012-10-05
Structural Analysis
A. Villarino, R. Duran et al. Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions. J. Mol. Biol. 2005
InteractionActivatedBy Rv1827activemadhulsbu2012-10-05
Spectrophotometric
A. Villarino, R. Duran et al. Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions. J. Mol. Biol. 2005
InteractionSignaling Rv1436activeyashabhasin2012-10-05
Structural Analysis
authors,BK. Ratha,MS. Kanungo Induction of particulate and soluble isoenzymes of tyrosine aminotransferase by hydrocortisone in the liver of rats as a function of age. Biochem. Biophys. Res. Commun. 1977
InteractionSignaling Rv1436activeyashabhasin2012-10-05
Structural Analysis
authors,H. Nürnberger [Quantitative colorimetric determination of 1-(4-cyclohexylureidophenoxy)-2-hydroxy-3-tert butylaminopropane (talinolol Cordanum, 02-115) in body fluids]. Pharmazie 1975
InteractionSignaling Rv1436activeyashabhasin2012-10-05
Structural Analysis
authors,KV. Kaloustian,JJ. Poluhowich The role of organic phosphates in modulating the oxygenation behavior of eel hemoglobin. Comp Biochem Physiol A Comp Physiol 1976
InteractionSignaling Rv1436activeyashabhasin2012-10-05
Spectrophotometric
authors,BK. Ratha,MS. Kanungo Induction of particulate and soluble isoenzymes of tyrosine aminotransferase by hydrocortisone in the liver of rats as a function of age. Biochem. Biophys. Res. Commun. 1977
InteractionSignaling Rv1436activeyashabhasin2012-10-05
Spectrophotometric
authors,H. Nürnberger [Quantitative colorimetric determination of 1-(4-cyclohexylureidophenoxy)-2-hydroxy-3-tert butylaminopropane (talinolol Cordanum, 02-115) in body fluids]. Pharmazie 1975
InteractionSignaling Rv1436activeyashabhasin2012-10-05
Spectrophotometric
authors,KV. Kaloustian,JJ. Poluhowich The role of organic phosphates in modulating the oxygenation behavior of eel hemoglobin. Comp Biochem Physiol A Comp Physiol 1976
InteractionInhibits Rv1222activeharsharohiratruefriend2012-10-05
mass spectrometry
R. Manganelli,R. Provvedi,S. Rodrigue,J. Beaucher,L. Gaudreau,I. Smith,R. Proveddi Sigma factors and global gene regulation in Mycobacterium tuberculosis. J. Bacteriol. 2004
InteractionInhibits Rv1222activeharsharohiratruefriend2012-10-05
mass spectrometry
S. Barik, K. Sureka et al. RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis. Mol. Microbiol. 2010
InteractionPhysicalInteraction Rv1018cactiveashwinigbhat2012-10-05
Structural Analysis
A. Parikh, SK. Verma et al. PknB-Mediated Phosphorylation of a Novel Substrate, N-Acetylglucosamine-1-Phosphate Uridyltransferase, Modulates Its Acetyltransferase Activity. J. Mol. Biol. 2008
InteractionPhysicalInteraction Rv1018cactiveashwinigbhat2012-10-05
Structural Analysis
W. Zhang, VC. Jones et al. Expression, essentiality, and a microtiter plate assay for mycobacterial GlmU, the bifunctional glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase. Int. J. Biochem. Cell Biol. 2008
InteractionPhysicalInteraction Rv1018cactivepriti.priety2012-10-05
Structural Analysis
A. Parikh, SK. Verma et al. PknB-Mediated Phosphorylation of a Novel Substrate, N-Acetylglucosamine-1-Phosphate Uridyltransferase, Modulates Its Acetyltransferase Activity. J. Mol. Biol. 2008
InteractionPhysicalInteraction Rv1018cactivepriti.priety2012-10-05
Structural Analysis
W. Zhang, VC. Jones et al. Expression, essentiality, and a microtiter plate assay for mycobacterial GlmU, the bifunctional glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase. Int. J. Biochem. Cell Biol. 2008
InteractionSignaling Rv0020cactivevmevada1022012-10-05
Affinity purification (Physical interaction)
C. Grundner, LM. Gay et al. Mycobacterium tuberculosis serine/threonine kinases PknB, PknD, PknE, and PknF phosphorylate multiple FHA domains. Protein Sci. 2005
InteractionSignaling Rv0019cactivevmevada1022012-10-05
Spectrophotometric Analysis
M. Gupta,A. Sajid,G. Arora,V. Tandon,Y. Singh Forkhead-associated domain-containing protein Rv0019c and polyketide-associated protein PapA5, from substrates of serine/threonine protein kinase PknB to interacting proteins of Mycobacterium tuberculosis. J. Biol. Chem. 2009
InteractionSignaling Rv0018cactivevmevada1022012-10-05
Spectrophotometric Analysis
B. Boitel, M. Ortiz-Lombardía et al. PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis. Mol. Microbiol. 2003
InteractionSignaling Rv0018cactivevmevada1022012-10-05
Spectrophotometric Analysis
P. Chopra, B. Singh et al. Phosphoprotein phosphatase of Mycobacterium tuberculosis dephosphorylates serine-threonine kinases PknA and PknB. Biochem. Biophys. Res. Commun. 2003
InteractionActivation Rv0016cactivevmevada1022012-10-05
Co-expression (Functional linkage)
A. Dasgupta, P. Datta et al. The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell division. Microbiology (Reading, Engl.) 2006
InteractionSignaling Rv0015cactivevmevada1022012-10-05
Functional linkage (Co-expression)
CM. Kang, DW. Abbott et al. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 2005
InteractionSignaling Rv0015cactivevmevada1022012-10-05
Functional linkage (Co-expression)
A. Narayan, P. Sachdeva et al. Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol. Genomics 2007
InteractionSignaling Rv3221Aactivejgalag2012-10-05
Affinity purification (Physical interaction)
ST. Park, CM. Kang et al. Regulation of the SigH stress response regulon by an essential protein kinase in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2008
InteractionSignaling Rv1827activeakankshajain.212012-10-05
Structural Analysis
A. Villarino, R. Duran et al. Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions. J. Mol. Biol. 2005
InteractionSignaling Rv1827activeakankshajain.212012-10-05
Spectrophotometric
A. Villarino, R. Duran et al. Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions. J. Mol. Biol. 2005
InteractionSignaling Rv0014cactivejgalag2012-10-05
Structural Analysis
CM. Kang, DW. Abbott et al. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 2005
InteractionSignaling Rv0014cactivejgalag2012-10-05
Structural Analysis
CM. Kang, DW. Abbott et al. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 2005
InteractionSignaling Rv0014cactivejgalag2012-10-05
Structural Analysis
A. Narayan, P. Sachdeva et al. Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol. Genomics 2007
InteractionSignaling Rv0014cactivejgalag2012-10-05
Structural Analysis
A. Narayan, P. Sachdeva et al. Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol. Genomics 2007
InteractionSignaling Rv0014cactivejgalag2012-10-05
Spectrophotometric
CM. Kang, DW. Abbott et al. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 2005
InteractionSignaling Rv0014cactivejgalag2012-10-05
Spectrophotometric
CM. Kang, DW. Abbott et al. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 2005
InteractionSignaling Rv0014cactivejgalag2012-10-05
Spectrophotometric
A. Narayan, P. Sachdeva et al. Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol. Genomics 2007
InteractionSignaling Rv0014cactivejgalag2012-10-05
Spectrophotometric
A. Narayan, P. Sachdeva et al. Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol. Genomics 2007
InteractionSignaling Rv0015cactivevmevada1022012-10-05
Structural Analysis
CM. Kang, DW. Abbott et al. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 2005
InteractionSignaling Rv0015cactivevmevada1022012-10-05
Structural Analysis
A. Narayan, P. Sachdeva et al. Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol. Genomics 2007
InteractionSignaling Rv0015cactivevmevada1022012-10-05
Structural Analysis
CM. Kang, DW. Abbott et al. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 2005
InteractionSignaling Rv0015cactivevmevada1022012-10-05
Structural Analysis
A. Narayan, P. Sachdeva et al. Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol. Genomics 2007
InteractionSignaling Rv0015cactivevmevada1022012-10-05
Spectrophotometric
CM. Kang, DW. Abbott et al. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 2005
InteractionSignaling Rv0015cactivevmevada1022012-10-05
Spectrophotometric
A. Narayan, P. Sachdeva et al. Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol. Genomics 2007
InteractionSignaling Rv0015cactivevmevada1022012-10-05
Spectrophotometric
CM. Kang, DW. Abbott et al. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 2005
InteractionSignaling Rv0015cactivevmevada1022012-10-05
Spectrophotometric
A. Narayan, P. Sachdeva et al. Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol. Genomics 2007
InteractionSignaling Rv0015cactivevmevada1022012-10-05
Affinity purification (Physical interaction)
CM. Kang, DW. Abbott et al. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 2005
InteractionSignaling Rv0015cactivevmevada1022012-10-05
Affinity purification (Physical interaction)
A. Narayan, P. Sachdeva et al. Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol. Genomics 2007
InteractionSignaling Rv0015cactivevmevada1022012-10-05
Affinity purification (Physical interaction)
CM. Kang, DW. Abbott et al. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 2005
InteractionSignaling Rv0015cactivevmevada1022012-10-05
Affinity purification (Physical interaction)
A. Narayan, P. Sachdeva et al. Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol. Genomics 2007
InteractionSignaling Rv0016cactivevmevada1022012-10-05
Co-expression (Functional linkage)
A. Narayan, P. Sachdeva et al. Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol. Genomics 2007
InteractionSignaling Rv0016cactivevmevada1022012-10-05
Co-expression (Functional linkage)
A. Dasgupta, P. Datta et al. The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell division. Microbiology (Reading, Engl.) 2006
NameTRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE, known to phosphorylate InhA;KasA, KasBactivemjackson2012-10-05
Regulatory proteins