Rv0016c - penicillin-binding protein pbpA

Expression: Most Significant Conditions for Rv0016c

Protein Domains

Gene Information
Locus	Rv0016c
Symbol	pbpA
Gene Name	penicillin-binding protein pbpA
Location	18759 - 20234 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1476 bp Protein:492 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	35649
Related Genes	Acel_0020 CE0035 cg0060 DIP0055 jk0039 MAP0019c MAV_0020 Mkms_0025 ML0018 Mmcs_0017 MSMEG_0031 MT0019 MUL_0020 Mvan_0025 nfa820 SAV4339
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0016c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0016c Transcript 1
MNASLRRISVTVMALIVLLLLNATMTQVFTADGLRADPRNQRVLLDEYSRQRGQITAGGQ
LLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYSSTALERAEDPILNGSDRRLFGRRL
ADFFTGRDPRGGNVDTTINPRIQQAGWDAMQQGCYGPCKGAVVALEPSTGKILALVSSPS
YDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAISETYPPGSTFKVITTAAALAAGATET
EQLTAAPTIPLPGSTAQLENYGGAPCGDEPTVSLREAFVKSCNTAFVQLGIRTGADALRS
MARAFGLDSPPRPTPLQVAESTVGPIPDSAALGMTSIGQKDVALTPLANAEIAATIANGG
ITMRPYLVGSLKGPDLANISTTVGYQQRRAVSPQVAAKLTELMVGAEKVAQQKGAIPGVQ
IASKTGTAEHGTDPRHTPPHAWYIAFAPAQAPKVAVAVLVENGADRLSATGGALAAPIGR
AVIEAALQGEP*

Genomic Sequence

>Rv0016c
ATGAACGCCTCTCTGCGCCGAATATCGGTGACCGTGATGGCGTTGATCGTGTTGCTACTG
CTCAACGCGACCATGACGCAGGTCTTCACCGCCGACGGGCTGCGTGCCGATCCCCGCAAC
CAGCGAGTGTTGCTCGACGAGTATTCACGGCAGCGCGGCCAGATCACCGCTGGTGGCCAA
CTGCTGGCGTACTCGGTAGCCACCGACGGCCGCTTTCGTTTCCTGCGGGTCTATCCCAAT
CCTGAGGTGTACGCGCCGGTTACCGGCTTCTACTCCCTGCGCTATTCCAGCACCGCCCTA
GAACGAGCCGAGGACCCGATATTGAACGGGTCCGACCGCCGTCTGTTCGGCCGCCGGCTG
GCCGACTTCTTCACCGGTCGCGACCCACGCGGCGGTAATGTCGATACCACGATCAACCCG
CGCATTCAGCAAGCCGGCTGGGACGCGATGCAGCAAGGCTGCTACGGGCCCTGTAAGGGA
GCGGTGGTCGCCCTTGAGCCATCAACCGGCAAGATTTTGGCGTTGGTGTCTTCTCCGTCC
TACGACCCCAACCTGCTGGCGTCGCATAACCCCGAGGTGCAGGCGCAAGCCTGGCAGCGG
CTTGGCGACAATCCCGCCTCTCCACTGACCAACCGTGCCATCTCTGAGACGTATCCACCG
GGTTCGACTTTCAAAGTGATCACCACTGCGGCCGCGCTGGCCGCCGGGGCCACCGAGACC
GAACAGCTGACTGCGGCGCCCACAATTCCGTTGCCAGGCAGCACCGCCCAGCTAGAGAAC
TACGGCGGTGCGCCGTGCGGGGACGAACCCACCGTGTCGCTGCGTGAGGCATTCGTCAAA
TCATGCAACACCGCATTCGTCCAGCTGGGCATCCGCACCGGCGCCGACGCCCTGCGCAGC
ATGGCGCGCGCGTTCGGTCTCGATAGCCCACCGCGCCCAACTCCGCTGCAAGTGGCGGAA
TCAACCGTCGGGCCTATCCCGGACAGCGCCGCACTAGGGATGACCAGTATCGGCCAAAAG
GACGTTGCGCTGACCCCGCTAGCGAACGCAGAAATAGCCGCGACCATCGCAAACGGCGGC
ATTACGATGAGGCCTTATCTAGTCGGCAGCCTCAAGGGACCGGACCTAGCCAATATCTCA
ACCACCGTCGGATACCAGCAGCGCCGCGCGGTGTCACCGCAGGTCGCCGCTAAGCTAACA
GAGCTGATGGTCGGCGCCGAGAAAGTCGCACAGCAGAAAGGGGCAATCCCCGGCGTGCAG
ATCGCATCCAAGACGGGCACCGCCGAACATGGCACCGACCCTCGTCACACTCCACCGCAC
GCTTGGTACATCGCCTTTGCGCCCGCACAAGCGCCCAAGGTGGCTGTTGCCGTGCTGGTG
GAGAACGGGGCTGATCGGCTGTCCGCCACCGGAGGTGCCCTCGCGGCACCGATCGGGCGG
GCGGTGATCGAAGCCGCACTGCAGGGGGAACCATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Signaling Rv2145c	active	sourish10	2012-10-05
	yeast-two-or-three hybrid (physical interaction) P. Mukherjee, K. Sureka et al. Novel role of Wag31 in protection of mycobacteria under oxidative stress. Mol. Microbiol. 2009
Interaction	Signaling Rv2145c	active	ahal4789	2012-10-05
	yeast-two-or-three hybrid (physical interaction) P. Mukherjee, K. Sureka et al. Novel role of Wag31 in protection of mycobacteria under oxidative stress. Mol. Microbiol. 2009
Interaction	PhysicalInteraction Rv0050	active	singhpankaj2116	2012-10-05
	Band Shift authors,H. Billman-Jacobe,RE. Haites,RL. Coppel Characterization of a Mycobacterium smegmatis mutant lacking penicillin binding protein 1. Antimicrob. Agents Chemother. 1999
Interaction	PhysicalInteraction Rv0050	active	singhpankaj2116	2012-10-05
	Band Shift A. Fedarovich,RA. Nicholas,C. Davies Unusual conformation of the SxN motif in the crystal structure of penicillin-binding protein A from Mycobacterium tuberculosis. J. Mol. Biol. 2010
Interaction	PhysicalInteraction Rv0050	active	singhpankaj2116	2012-10-05
	Band Shift authors,M. Strong,TG. Graeber,M. Beeby,M. Pellegrini,MJ. Thompson,TO. Yeates,D. Eisenberg Visualization and interpretation of protein networks in Mycobacterium tuberculosis based on hierarchical clustering of genome-wide functional linkage maps. Nucleic Acids Res. 2003
Interaction	Regulatory Rv0017c	active	vmevada102	2012-10-05
	Functional linkage (operon) authors,H. Matsuzawa,S. Asoh,K. Kunai,K. Muraiso,A. Takasuga,T. Ohta Nucleotide sequence of the rodA gene, responsible for the rod shape of Escherichia coli: rodA and the pbpA gene, encoding penicillin-binding protein 2, constitute the rodA operon. J. Bacteriol. 1989
Interaction	Regulatory Rv0017c	active	vmevada102	2012-10-05
	Functional linkage (operon) A. Dasgupta, P. Datta et al. The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell division. Microbiology (Reading, Engl.) 2006
Interaction	Activation Rv0014c	active	vmevada102	2012-10-05
	Co-expression (Functional linkage) A. Dasgupta, P. Datta et al. The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell division. Microbiology (Reading, Engl.) 2006
Interaction	Signaling Rv0014c	active	vmevada102	2012-10-05
	Co-expression (Functional linkage) A. Narayan, P. Sachdeva et al. Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol. Genomics 2007
Interaction	Signaling Rv0014c	active	vmevada102	2012-10-05
	Co-expression (Functional linkage) A. Dasgupta, P. Datta et al. The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell division. Microbiology (Reading, Engl.) 2006
Name	Class B penicillin binding protein	active	mjackson	2012-10-05
	Cell division
Name	Class B penicillin binding protein	active	mjackson	2012-10-05
	Cell division