Rv0046c - myo-inositol-1-phosphate synthase ino1

Expression: Most Significant Conditions for Rv0046c

Protein Domains

Gene Information
Locus	Rv0046c
Symbol	ino1
Gene Name	myo-inositol-1-phosphate synthase ino1
Location	50021 - 51124 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1104 bp Protein:368 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	19012
Related Genes	Acel_2138 CE2831 cg3323 DIP0115 jk2071 MAP0060c MAV_0067 Mkms_5465 ML2692 Mmcs_5376 MSMEG_6904 MT0052 MUL_0064 Mvan_6040 nfa55520 SAV4296
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0046c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0046c Transcript 1
MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTSTVPGLMHVRFGPYHVR
DVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTNVIVQRGPTLDGIGKYYADTI
ELSDAEPVDVVQALKEAKVDVLVSYLPVGSEEADKFYAQCAIDAGVAFVNALPVFIASDP
VWAKKFTDARVPIVGDDIKSQVGATITHRVLAKLFEDRGVQLDRTMQLNVGGNMDFLNML
ERERLESKKISKTQAVTSNLKREFKTKDVHIGPSDHVGWLDDRKWAYVRLEGRAFGDVPL
NLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASAYLMKSPPEQLPDDIARAQ
LEEFIIG*

Genomic Sequence

>Rv0046c
ATGAGTGAGCACCAGTCGTTACCGGCGCCGGAGGCGTCGACGGAGGTTCGAGTCGCCATT
GTCGGCGTCGGCAACTGCGCGTCCTCGCTGGTCCAGGGCGTCGAGTACTACTACAACGCC
GACGACACATCGACCGTACCGGGCCTCATGCACGTGCGGTTCGGCCCGTACCACGTTCGC
GACGTCAAGTTCGTGGCGGCGTTCGACGTGGACGCCAAGAAGGTCGGCTTCGACCTGTCC
GACGCCATCTTCGCCTCGGAGAACAACACCATCAAGATCGCCGATGTGGCGCCGACCAAC
GTGATCGTGCAGCGCGGGCCTACCCTCGATGGCATCGGCAAGTACTACGCCGACACCATC
GAACTCTCCGACGCGGAGCCCGTCGACGTCGTCCAGGCGCTCAAGGAGGCCAAGGTCGAC
GTGCTGGTCTCCTATTTGCCGGTGGGCTCGGAGGAAGCCGACAAGTTCTACGCCCAGTGT
GCTATCGACGCCGGGGTGGCGTTCGTCAACGCGCTGCCGGTGTTCATCGCCTCCGACCCG
GTGTGGGCCAAGAAGTTCACCGACGCCAGGGTACCCATCGTCGGTGATGACATCAAGAGC
CAGGTCGGCGCGACGATCACCCACCGGGTGCTGGCCAAGCTGTTCGAGGACCGCGGCGTG
CAGCTCGACCGCACCATGCAGCTCAACGTGGGCGGCAACATGGACTTCCTCAACATGCTC
GAACGTGAACGGCTGGAGTCCAAGAAGATCTCCAAGACCCAGGCCGTCACTTCGAATCTG
AAGCGCGAGTTCAAGACCAAGGACGTGCACATCGGCCCGTCCGACCACGTCGGATGGCTC
GACGATCGCAAATGGGCCTATGTCCGTCTTGAGGGCCGCGCCTTCGGAGATGTGCCGTTG
AACCTGGAGTACAAGCTCGAGGTGTGGGACTCGCCAAACTCGGCCGGCGTCATCATCGAC
GCGGTGCGGGCGGCCAAGATCGCCAAGGACCGCGGCATCGGCGGACCGGTGATCCCGGCG
TCGGCCTACCTGATGAAGAGCCCGCCCGAGCAGCTGCCCGACGACATCGCGCGCGCGCAA
CTCGAAGAGTTCATCATCGGTTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Operon Rv0048c	active	priti.priety	2012-10-05
	Structural Analysis authors,Y. Xiong,MJ. Chalmers,FP. Gao,TA. Cross,AG. Marshall Identification of Mycobacterium tuberculosis H37Rv integral membrane proteins by one-dimensional gel electrophoresis and liquid chromatography electrospray ionization tandem mass spectrometry. J. Proteome Res. null
Interaction	Operon Rv0048c	active	priti.priety	2012-10-05
	Structural Analysis F. Movahedzadeh, DA. Smith et al. The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence. Mol. Microbiol. 2004
Interaction	Operon Rv0048c	active	priti.priety	2012-10-05
	Structural Analysis N. Scherr, S. Honnappa et al. Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2007
Interaction	Operon Rv0048c	active	priti.priety	2012-10-05
	Spectrophotometric authors,Y. Xiong,MJ. Chalmers,FP. Gao,TA. Cross,AG. Marshall Identification of Mycobacterium tuberculosis H37Rv integral membrane proteins by one-dimensional gel electrophoresis and liquid chromatography electrospray ionization tandem mass spectrometry. J. Proteome Res. null
Interaction	Operon Rv0048c	active	priti.priety	2012-10-05
	Spectrophotometric F. Movahedzadeh, DA. Smith et al. The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence. Mol. Microbiol. 2004
Interaction	Operon Rv0048c	active	priti.priety	2012-10-05
	Spectrophotometric N. Scherr, S. Honnappa et al. Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2007
Interaction	Operon Rv0047c	active	priti.priety	2012-10-05
	Structural Analysis authors,J. Gury,L. Barthelmebs,NP. Tran,C. Diviès,JF. Cavin Cloning, deletion, and characterization of PadR, the transcriptional repressor of the phenolic acid decarboxylase-encoding padA gene of Lactobacillus plantarum. Appl. Environ. Microbiol. 2004
Interaction	Operon Rv0047c	active	priti.priety	2012-10-05
	Structural Analysis F. Movahedzadeh, DA. Smith et al. The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence. Mol. Microbiol. 2004
Interaction	Operon Rv0047c	active	priti.priety	2012-10-05
	Spectrophotometric authors,J. Gury,L. Barthelmebs,NP. Tran,C. Diviès,JF. Cavin Cloning, deletion, and characterization of PadR, the transcriptional repressor of the phenolic acid decarboxylase-encoding padA gene of Lactobacillus plantarum. Appl. Environ. Microbiol. 2004
Interaction	Operon Rv0047c	active	priti.priety	2012-10-05
	Spectrophotometric F. Movahedzadeh, DA. Smith et al. The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence. Mol. Microbiol. 2004
Interaction	Inhibition Rv1963c	active	shahanup86	2012-10-05
	MD. Santangelo, LI. Klepp et al. Mce3R, a TetR-type transcriptional repressor, controls the expression of a regulon involved in lipid metabolism in Mycobacterium tuberculosis. Microbiology (Reading, Engl.) 2009
Interaction	RegulatedBy Rv1963c	active	yamir.moreno	2012-10-05
	Proteomic studies. Regulated gene product concentrations measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) using proteomics techniques. MP. Santangelo, FC. Blanco et al. Study of the role of Mce3R on the transcription of mce genes of Mycobacterium tuberculosis. BMC Microbiol. 2008