Rv0058 - replicative DNA helicase dnaB
Protein Domains

Gene Information
LocusRv0058
SymboldnaB
Gene Namereplicative DNA helicase dnaB
Location60396 - 63020 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:2625 bp
Protein:875 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number32769
Related GenesAcel_2083 BL0431 CE2816 cg3304 DIP2288 jk2062 MAP0071 MAV_0079 Mkms_5455 ML2680 Mmcs_5366 MSMEG_6892 MT0064 MUL_0075 Mvan_6030 nfa55760 PPA2244 SAV4284
Transcriptional Regulation
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Regulatory Network
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Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionActivatedBy Rv2343cactiveakankshajain.212012-10-05
Domain Fusion (Functional Linkage)
AG. Klann, AE. Belanger et al. Characterization of the dnaG locus in Mycobacterium smegmatis reveals linkage of DNA replication and cell division. J. Bacteriol. 1998
InteractionActivatedBy Rv2343cactiveakankshajain.212012-10-05
Domain Fusion (Functional Linkage)
authors,K. Tougu,H. Peng,KJ. Marians Identification of a domain of Escherichia coli primase required for functional interaction with the DnaB helicase at the replication fork. J. Biol. Chem. 1994
InteractionPhysicalInteraction Rv2343cactivevmevada1022012-10-05
Structural analysis
T. Biswas & OV. Tsodikov Hexameric ring structure of the N-terminal domain of Mycobacterium tuberculosis DnaB helicase. FEBS J. 2008
InteractionPhysicalInteraction Rv0001activevmevada1022012-10-05
Yeast two-hybrid (Physical interaction)
Y. Xie et al. Characterization of Physical Interaction between Replication Initiator Protein DnaA and Replicative Helicase from Mycobacterium tuberculosis H37Rv. Biochemistry Mosc. 2009
InteractionRegulatedBy Rv0348activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
InteractionRegulatedBy Rv1221activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
InteractionRegulatedBy Rv2720activeyamir.moreno2012-10-05
Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support.
G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
InteractionRegulatedBy Rv0491activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003