Rv0334 - alpha-D-glucose-1-phosphate thymidylyltransferase rmlA

Expression: Most Significant Conditions for Rv0334

Protein Domains

Gene Information
Locus	Rv0334
Symbol	rmlA
Gene Name	alpha-D-glucose-1-phosphate thymidylyltransferase rmlA
Location	398658 - 399524 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:867 bp Protein:289 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	33495
Related Genes	MAP3828 MAV_4820 Mkms_0446 ML2503 Mmcs_0436 MSMEG_0384 MT0348 MUL_0568 Mvan_0603
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0334
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0334 Transcript 1
MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMAGIRDIQLITTPHDAPG
FHRLLGDGAHLGVNISYATQDQPDGLAQAFVIGANHIGADSVALVLGDNIFYGPGLGTSL
KRFQSISGGAIFAYWVANPSAYGVVEFGAEGMALSLEEKPVTPKSNYAVPGLYFYDNDVI
EIARGLKKSARGEYEITEVNQVYLNQGRLAVEVLARGTAWLDTGTFDSLLDAADFVRTLE
RRQGLKVSIPEEVAWRMGWIDDEQLVQRARALVKSGYGNYLLELLERN*

Genomic Sequence

>Rv0334
ATGCGCGGGATCATCTTGGCCGGCGGTTCGGGCACCCGGCTGTACCCGATCACCATGGGG
ATCAGCAAGCAGCTGCTGCCGGTCTACGACAAACCGATGATCTACTACCCGCTCACCACG
CTGATGATGGCTGGGATCCGAGACATTCAGTTGATCACCACCCCGCATGACGCGCCCGGC
TTTCATCGACTCCTGGGCGACGGCGCGCACTTGGGAGTGAACATCAGCTACGCCACCCAG
GATCAGCCTGACGGTCTGGCGCAGGCGTTCGTCATTGGCGCCAACCACATCGGCGCCGAT
TCGGTGGCATTGGTGTTGGGGGACAACATCTTCTACGGCCCAGGTCTGGGGACCAGCCTG
AAGCGCTTCCAATCCATCAGTGGTGGAGCAATTTTCGCCTATTGGGTAGCCAACCCGTCG
GCCTATGGTGTCGTTGAGTTCGGCGCCGAGGGCATGGCGCTGTCTCTGGAGGAGAAGCCG
GTGACCCCGAAGTCGAATTACGCGGTGCCGGGCCTGTATTTCTATGACAACGATGTGATC
GAAATCGCCAGGGGTTTAAAGAAATCAGCGCGCGGGGAGTACGAGATCACCGAGGTCAAC
CAGGTCTACCTCAATCAGGGTAGGTTGGCGGTCGAGGTGCTGGCCCGCGGGACAGCGTGG
CTGGACACCGGGACATTCGACTCGCTGCTGGACGCCGCCGATTTCGTCCGGACCCTGGAG
CGTCGGCAGGGCCTGAAGGTCAGCATCCCCGAAGAAGTGGCGTGGCGCATGGGCTGGATC
GACGACGAGCAGCTGGTGCAGCGAGCCCGTGCTCTGGTCAAGTCCGGATATGGTAACTAC
CTGCTGGAGTTGTTGGAGCGCAACTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Name	Glucose-1-phosphate thymidylyltransferase to form dTDP-Glucose [dTDP-Glucose synthase], the first step in dTDP-Rha synthesis	active	mjackson	2012-10-05
	dTDP-Rhamnose synthesis
Term	GO:0019305 dTDP-rhamnose biosynthetic process - NR	active	mmcneil	2012-03-05
	Glucose-1-phosphate thymidylyltransferase to form dTDP-Glucose. dTDP-Glucose synthase the first step in dTDP-rha synthesis; enzymatic evidence Y. Ma, RJ. Stern et al. Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose. Antimicrob. Agents Chemother. 2001