Rv0458 - aldehyde dehydrogenase

Expression: Most Significant Conditions for Rv0458

Protein Domains

Gene Information
Locus	Rv0458
Symbol
Gene Name	aldehyde dehydrogenase
Location	549675 - 551198 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1524 bp Protein:508 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	27145
Related Genes	MAP3952 MAV_4691 Mkms_0640 Mmcs_0627 MSMEG_0900 MT0474 MUL_1416
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0458
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0458 Transcript 1
MTVFSRPGSAGALMSYESRYQNFIGGQWVAPVHGRYFENPTPVTGQPFCEVPRSDAADID
KALDAAHAAAPGWGKTAPAERAAILNMIADRIDKNAAALAVAEVWDNGKPVREALAADIP
LAVDHFRYFAAAIRAQEGALSQIDEDTVAYHFHEPLGVVGQIIPWNFPILMAAWKLAPAL
AAGNTAVLKPAEQTPASVLYLMSLIGDLLPPGVVNVVNGFGAEAGKPLASSDRIAKVAFT
GETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAHDDFCDKALEGFTMFALNQGE
VCTCPSRSLIQADIYDEFLELAAIRTKAVRQGDPLDTETMLGSQASNDQLEKVLSYIEIG
KQEGAVIIAGGERAELGGDLSGGYYMQPTIFTGTNNMRIFKEEIFGPVVAVTSFTDYDDA
IGIANDTLYGLGAGVWSRDGNTAYRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGRE
GHQMMLQHYQHTKNLLVSYSDKALGFF*

Genomic Sequence

>Rv0458
ATGACTGTCTTTTCCCGTCCCGGTTCCGCCGGGGCGCTGATGTCCTATGAATCCCGGTAC
CAAAACTTCATCGGGGGCCAGTGGGTCGCGCCGGTCCATGGGCGCTACTTCGAGAACCCG
ACGCCGGTGACCGGCCAGCCGTTCTGCGAGGTGCCGCGCTCCGACGCGGCCGACATCGAC
AAGGCGCTCGACGCCGCGCACGCGGCGGCGCCGGGGTGGGGCAAGACCGCACCGGCCGAA
CGGGCGGCGATCCTCAACATGATTGCCGACCGCATCGACAAGAACGCCGCCGCGCTGGCG
GTGGCCGAGGTCTGGGACAACGGGAAACCGGTCCGGGAAGCGCTGGCCGCCGATATCCCG
TTGGCGGTCGATCACTTCCGGTACTTCGCCGCGGCGATTCGCGCCCAGGAGGGCGCGCTG
AGCCAGATCGACGAGGACACCGTGGCCTACCACTTCCACGAGCCGCTCGGCGTGGTGGGC
CAGATCATTCCGTGGAACTTCCCCATCCTGATGGCGGCCTGGAAGCTGGCGCCGGCGTTG
GCGGCCGGCAACACGGCGGTGCTCAAACCCGCCGAGCAGACACCCGCTTCGGTGCTCTAC
CTGATGTCGCTGATCGGTGATCTGTTGCCGCCCGGGGTGGTCAACGTGGTCAACGGATTC
GGCGCCGAGGCCGGCAAGCCGTTGGCCTCCAGCGACCGCATCGCCAAGGTCGCGTTCACC
GGGGAAACCACCACGGGGCGGCTGATCATGCAATACGCCTCGCACAACCTGATCCCGGTC
ACCCTGGAACTCGGCGGCAAGAGCCCCAACATCTTCTTCGCCGACGTGCTGGCCGCCCAC
GACGACTTCTGCGACAAGGCGCTGGAAGGCTTCACCATGTTCGCCCTCAACCAGGGCGAG
GTGTGCACCTGCCCGTCGCGCAGTCTGATCCAGGCCGACATCTACGACGAGTTCCTGGAG
CTGGCGGCGATCCGGACCAAGGCGGTCCGGCAGGGCGACCCGCTGGACACCGAAACCATG
CTGGGTTCCCAGGCCTCCAACGACCAGCTGGAAAAGGTGTTGTCCTACATCGAAATCGGC
AAGCAAGAGGGTGCGGTGATTATCGCCGGAGGCGAGCGCGCCGAACTAGGCGGCGACCTG
TCCGGCGGTTATTACATGCAGCCGACGATCTTCACCGGCACCAACAACATGCGGATTTTC
AAGGAGGAGATCTTCGGGCCGGTGGTCGCGGTGACGTCGTTCACCGATTACGACGACGCG
ATCGGCATCGCCAACGACACCCTCTACGGCTTGGGTGCCGGTGTGTGGAGCCGCGACGGC
AACACTGCCTATCGGGCCGGGCGGGACATCCAGGCCGGCCGGGTGTGGGTCAACTGCTAC
CACCTCTACCCCGCGCACGCGGCGTTCGGCGGCTACAAGCAGTCCGGCATCGGCCGGGAG
GGCCACCAGATGATGCTGCAGCACTACCAGCACACCAAGAACCTGCTGGTGTCCTACTCG
GATAAGGCGCTGGGGTTCTTCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Symbol	aldh	curated	catest	2010-10-08
	Farrell Wymore suggests adding this symbol.
Symbol	aldh	curated	catest	2010-10-08
	Farrell Wymore suggests adding this symbol.
Symbol	aldh	curated	catest	2010-10-08
	Farrell asked me to add this
Symbol	aldh	curated	catest	2010-10-08
	Farrell asked me to add this
Symbol	aldh	curated	catest	2010-10-08
	Farrell asked me to add this
Symbol	aldh	curated	catest	2010-10-08
	Farrell asked me to add this
Symbol	aldh	curated	catest	2010-10-08
	Farrell asked me to add this