Rv0468 - 3-hydroxybutyryl-CoA dehydrogenase fadB2

Expression: Most Significant Conditions for Rv0468

Protein Domains

Gene Information
Locus	Rv0468
Symbol	fadB2
Gene Name	3-hydroxybutyryl-CoA dehydrogenase fadB2
Location	558895 - 559755 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:861 bp Protein:287 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	34779
Related Genes	Acel_0147 Acel_0658 BL0058 MAP3962 MAV_4681 Mkms_0650 ML2461 Mmcs_0637 MSMEG_0912 MT0484 MUL_4537 Mvan_0802 nfa52290 SAV1909 SAV2870 SAV2889
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0468
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0468 Transcript 1
MSDAIQRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEALITAGRNRIVKSLERAVSAGK
VTERERDRALGLLTFTTDLNDLSDRQLVIEAVVEDEAVKSEIFAELDRVVTDPDAVLASN
TSSIPIMKVAAATKQPQRVLGLHFFNPVPVLPLVELVRTLVTDEAAAARTEEFASTVLGK
QVVRCSDRSGFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMGPLRLSDLVG
LDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGRGFYTY*

Genomic Sequence

>Rv0468
GTGAGCGATGCGATCCAGCGGGTAGGGGTTGTCGGGGCCGGGCAGATGGGGTCCGGCATC
GCCGAGGTCTCGGCTCGCGCCGGCGTCGAAGTGACGGTGTTCGAGCCGGCCGAGGCGTTG
ATCACCGCGGGACGCAACCGCATCGTGAAGTCGCTGGAGCGGGCCGTCAGCGCCGGCAAG
GTAACCGAGCGCGAGCGTGACCGCGCCCTCGGCCTGTTGACCTTCACCACCGACCTCAAC
GACCTATCCGATAGGCAACTGGTGATCGAGGCCGTTGTCGAGGACGAGGCCGTCAAGTCC
GAGATCTTCGCCGAGCTCGACCGGGTCGTCACCGATCCGGACGCGGTGCTGGCGTCGAAT
ACCTCCAGCATCCCGATCATGAAGGTCGCCGCGGCCACCAAGCAGCCGCAACGGGTTCTT
GGCCTGCATTTCTTCAATCCGGTCCCGGTGCTGCCGCTGGTCGAGTTGGTGCGCACGCTG
GTCACCGACGAAGCCGCCGCCGCGCGCACGGAGGAGTTTGCCAGTACTGTGCTGGGCAAA
CAGGTCGTGCGTTGCTCCGACCGCTCCGGATTCGTGGTCAATGCGCTCCTGGTGCCGTAT
TTGCTGTCGGCGATTCGGATGGTCGAGGCCGGGTTTGCCACCGTCGAAGATGTCGACAAG
GCCGTTGTTGCGGGGTTATCGCACCCGATGGGTCCGCTGCGGCTTTCCGATCTTGTCGGC
CTAGACACCCTCAAGCTGATCGCGGACAAGATGTTCGAAGAATTCAAAGAACCGCACTAC
GGGCCCCCTCCGCTGTTGCTGCGTATGGTTGAGGCGGGCCAGTTGGGAAAGAAATCGGGT
CGAGGTTTCTACACGTACTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
Interaction	RegulatedBy Rv3416	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv3133c	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv2710	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv2017	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	RegulatedBy Rv1221	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
Interaction	RegulatedBy Rv1221	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008