Rv0490 - two component system sensor histidine kinase senX3
Protein Domains

Gene Information
LocusRv0490
SymbolsenX3
Gene Nametwo component system sensor histidine kinase senX3
Location579349 - 580581 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:1233 bp
Protein:411 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number37271
Related GenesCE0424 cg0483 DIP0390 jk1911 MAP3982 MAV_4661 Mkms_0673 ML2440 Mmcs_0660 MSMEG_0936 MT0509 MUL_4559 Mvan_0830 nfa51870
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
Search for regulators of Rv0490
Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionTranscription Rv3750cactivesourish102012-10-05
Co-expression (Functional linkage)
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
InteractionTranscription Rv3749cactivesourish102012-10-05
Co-expression (Functional linkage)
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
InteractionTranscription Rv2337cactivegirishgene072012-10-05
Co-expression (Functional linkage)
authors,KG. Mawuenyega,CV. Forst,KM. Dobos,JT. Belisle,J. Chen,EM. Bradbury,AR. Bradbury,X. Chen Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 2005
InteractionTranscription Rv2337cactivegirishgene072012-10-05
Co-expression (Functional linkage)
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
InteractionTranscription Rv2337cactivegirishgene072012-10-05
Co-expression (Functional linkage)
authors,CM. Sassetti,DH. Boyd,EJ. Rubin Genes required for mycobacterial growth defined by high density mutagenesis. Mol. Microbiol. 2003
InteractionRegulatory Rv2069activeashwinigbhat2012-10-05
Co-expression (Functional linkage)
R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
InteractionRegulatory Rv2069activepriti.priety2012-10-05
Co-expression (Functional linkage)
R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
InteractionTranscription Rv1433activesourish102012-10-05
Co-expression (Functional linkage)
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
InteractionRegulatory Rv1355cactiveswetha.r2012-10-05
Co-expression (Functional linkage)
L. Vera-Cabrera, CA. Molina-Torres et al. Genetic characterization of Mycobacterium tuberculosis clinical isolates with deletions in the plcA-plcB-plcC locus. Tuberculosis (Edinburgh, Scotland) 2007
InteractionRegulatory Rv1355cactiveswetha.r2012-10-05
Co-expression (Functional linkage)
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
InteractionRegulatory Rv0491activeprabhakarsmail2012-10-05
Affinity purification (Physical interaction)
authors,S. Himpens,C. Locht,P. Supply Molecular characterization of the mycobacterial SenX3-RegX3 two-component system: evidence for autoregulation. Microbiology (Reading, Engl.) 2000
InteractionRegulatory Rv0491activeprabhakarsmail2012-10-05
Affinity purification (Physical interaction)
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
InteractionRegulatory Rv0491activeakankshajain.212012-10-05
Affinity purification (Physical interaction)
authors,S. Himpens,C. Locht,P. Supply Molecular characterization of the mycobacterial SenX3-RegX3 two-component system: evidence for autoregulation. Microbiology (Reading, Engl.) 2000
InteractionRegulatory Rv0491activeakankshajain.212012-10-05
Affinity purification (Physical interaction)
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
InteractionRegulatedBy Rv0491activeyamir.moreno2012-10-05
Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. E.coli orthology based inference. Orthologous pair regulator-target found in E.coli.
G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
InteractionRegulatedBy Rv0491activeyamir.moreno2012-10-05
Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. E.coli orthology based inference. Orthologous pair regulator-target found in E.coli.
G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
InteractionRegulatedBy Rv0491activeyamir.moreno2012-10-05
E.coli orthology based inference. Orthologous pair regulator-target found in E.coli.
authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006