Rv0533c - 3-oxoacyl-[acyl-carrier-protein] synthase III fabH
Protein Domains

Gene Information
LocusRv0533c
SymbolfabH
Gene Name3-oxoacyl-[acyl-carrier-protein] synthase III fabH
Location624473 - 625480 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:1008 bp
Protein:336 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number29080
Related GenesAcel_0877 MAP4028c MAV_4612 MT0557 MUL_0632 nfa49790 nfa53970 PPA0983 SAV2290 SAV5787
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
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Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
TermTBRXN:FAS140 fatty acid synthase (n-C14:0) - IDAactivenjamshidi2012-10-05
mtFABH (Rv0533c) - link between FAS I and FAS II - highest affinity for C12:0, see PMID: 10840036 (since FA synthesis is lumped, does not extend immediately to FAS II).
KH. Choi, L. Kremer et al. Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. J. Biol. Chem. 2000
TermEC:2.3.1.85 Fatty-acid synthase. - IDAactivenjamshidi2012-10-05
mtFABH (Rv0533c) - link between FAS I and FAS II - highest affinity for C12:0, see PMID: 10840036 (since FA synthesis is lumped, does not extend immediately to FAS II).
KH. Choi, L. Kremer et al. Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. J. Biol. Chem. 2000
InteractionPhysicalInteraction Rv0533cactivejgalag2012-10-05
Structural analysis
JN. Scarsdale, G. Kazanina et al. Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III. J. Biol. Chem. 2001
InteractionPhysicalInteraction Rv0533cactivejgalag2012-10-05
Structural analysis
JN. Scarsdale, G. Kazanina et al. Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III. J. Biol. Chem. 2001
Name-Ketoacyl-ACP synthase III/3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE IIIactivemjackson2012-10-05
FAS-I->FAS-II
TermEC:2.3.1.180 Beta-ketoacyl-acyl-carrier-protein synthase III. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005
TermEC:2.3.1.41 Beta-ketoacyl-acyl-carrier-protein synthase I. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005