Rv0591 - MCE-family protein mce2C

Expression: Most Significant Conditions for Rv0591

Protein Domains

Gene Information
Locus	Rv0591
Symbol	mce2C
Gene Name	MCE-family protein mce2C
Location	689059 - 690504 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1446 bp Protein:482 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	21603
Related Genes	MAP4086 MAV_4549 MT0621
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0591
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0591 Transcript 1
MRTLTEFNRGRVGMMGAVVTVLVVGVAQSFTSVPMLFATPTYYAQFADTGGINTGDKVEI
AGVNVGLVRSLAIRGNRVLIGFSLPGKTIGMQSRAAIRTDTILGRKNLEIEPRGSEPLKP
NGFLPLAQTTTPYQIYDAFVDVTKAATGWDIDAVKRSLNVLSETFDQTAPHLSAALEGVK
AFSDTVGRRGEQIEQLLANANRIARVLGDRSEQVNGLLVNAKTLLAAFKQRSQALRILLT
NVSEASAQVSGLITDNPNLNHVLAQLRTVSEELVKRKNELADVAVLLGRYTAALTEAVGS
GPFFKAMVVNLLPYQILQPWVDAAFKKRGIDPENFWRSAGLPEFRWPDPNGTRFPNGAPP
AAPPVREGTPKHPGPAVPPGTPCSYTPAAGALPRPDTPLPCAGATVGPFGGPDFPAPLDV
QPSPPNPDGPPPTPGILSAGRPGEPAPAVPGIPMPLPPNAPPGARTQPLEPFPDGTGGSN
Q*

Genomic Sequence

>Rv0591
ATGAGAACGCTGACCGAGTTCAACCGCGGCCGTGTCGGGATGATGGGTGCGGTGGTCACG
GTGCTCGTCGTTGGTGTTGCGCAAAGCTTCACCAGCGTGCCGATGCTGTTCGCCACACCT
ACCTACTATGCGCAATTCGCCGACACGGGTGGCATCAACACGGGCGATAAGGTGGAAATC
GCTGGGGTGAACGTCGGGCTGGTGCGCTCGCTGGCAATCCGCGGCAACCGCGTGTTGATC
GGATTCTCGTTGCCCGGCAAGACAATCGGGATGCAAAGCCGGGCAGCAATTCGCACCGAC
ACCATTCTTGGCCGTAAGAACCTGGAGATCGAACCCCGCGGTTCGGAGCCGTTGAAACCC
AACGGTTTCCTGCCGTTGGCGCAGACCACTACGCCATACCAAATCTATGACGCGTTCGTC
GATGTCACGAAGGCGGCGACGGGCTGGGACATCGATGCCGTCAAACGCTCGCTAAACGTG
TTGTCGGAGACATTCGATCAGACCGCCCCGCATCTAAGTGCCGCCCTCGAGGGTGTCAAG
GCATTCTCCGACACCGTCGGCCGGCGCGGCGAGCAGATCGAGCAACTGCTGGCGAACGCC
AACAGGATCGCGCGCGTGCTCGGCGACCGCAGCGAGCAGGTCAACGGGCTGCTGGTGAAT
GCCAAGACGCTGCTGGCCGCGTTCAAGCAACGCAGCCAGGCACTGCGCATTCTGCTAACC
AACGTGTCGGAGGCATCAGCCCAGGTATCTGGCCTGATCACAGACAACCCCAACCTCAAC
CATGTGCTGGCCCAGTTGCGCACGGTCAGCGAGGAGCTGGTGAAGCGCAAGAACGAATTG
GCCGATGTAGCCGTCTTGCTCGGCAGATACACCGCGGCCCTGACAGAGGCCGTCGGTTCC
GGACCGTTCTTCAAGGCGATGGTGGTCAATCTGCTGCCCTACCAGATTCTTCAGCCCTGG
GTTGACGCGGCGTTCAAAAAGCGGGGCATCGACCCGGAGAACTTCTGGCGCAGTGCGGGT
CTGCCGGAATTCCGCTGGCCCGACCCCAACGGCACCCGGTTCCCCAACGGCGCGCCGCCG
GCGGCGCCACCGGTGCGGGAGGGTACACCCAAGCATCCGGGACCGGCCGTCCCGCCGGGA
ACGCCGTGCTCCTACACACCGGCGGCGGGCGCGTTGCCACGGCCCGACACCCCACTACCC
TGCGCGGGCGCCACCGTTGGCCCGTTCGGTGGACCCGACTTCCCGGCACCGCTCGATGTC
CAGCCGTCGCCGCCTAATCCCGATGGGCCGCCGCCGACGCCGGGCATCCTAAGTGCTGGG
CGGCCGGGCGAGCCGGCTCCGGCTGTTCCGGGCATACCGATGCCGCTGCCGCCGAACGCG
CCGCCGGGTGCACGCACCCAACCGCTTGAGCCGTTTCCTGACGGGACGGGAGGTAGCAAC
CAATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Operon Rv0594	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0594	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0594	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0593	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0593	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0593	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0593	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,M. Alonso-Hearn,TM. Eckstein,S. Sommer,LE. Bermudez A Mycobacterium avium subsp. paratuberculosis LuxR regulates cell envelope and virulence. Innate Immun 2010
Interaction	Operon Rv0592	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0592	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0592	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0594	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0593	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0592	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0590A	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0590	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0594	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0593	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0592	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0590A	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0590	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0594	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0593	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0592	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0590A	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0590	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0590A	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0590A	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0590A	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0590	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0590	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0590	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) AK. Das, D. Mitra et al. Predicted molecular structure of the mammalian cell entry protein Mce1A of Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 2003
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) D. Mitra, B. Saha et al. Correlating sequential homology of Mce1A, Mce2A, Mce3A and Mce4A with their possible functions in mammalian cell entry of Mycobacterium tuberculosis performing homology modeling. Tuberculosis (Edinburgh, Scotland) null
Interaction	Regulatory Rv0586	active	sourish10	2012-10-05
	Physical Interaction MD. Santangelo, F. Blanco et al. Mce2R from Mycobacterium tuberculosis represses the expression of the mce2 operon repressor from M. tuberculosis. Tuberculosis (Edinburgh, Scotland) 2008
Interaction	Regulatory Rv0586	active	sourish10	2012-10-05
	Physical Interaction authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Regulatory Rv0586	active	ahal4789	2012-10-05
	Physical Interaction MD. Santangelo, F. Blanco et al. Mce2R from Mycobacterium tuberculosis represses the expression of the mce2 operon repressor from M. tuberculosis. Tuberculosis (Edinburgh, Scotland) 2008
Interaction	Regulatory Rv0586	active	ahal4789	2012-10-05
	Physical Interaction authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	RegulatedBy Rv0586	active	yamir.moreno	2012-10-05
	LacZ-promoter fusion. expression levels of LacZ- regulated promoter fusion measured and compared between wild-type and trans-element mutation (knockout, over expression etc.). MD. Santangelo, F. Blanco et al. Mce2R from Mycobacterium tuberculosis represses the expression of the mce2 operon repressor from M. tuberculosis. Tuberculosis (Edinburgh, Scotland) 2008