Rv0643c - methoxy mycolic acid synthase 3 mmaA3

Expression: Most Significant Conditions for Rv0643c

Protein Domains

Gene Information
Locus	Rv0643c
Symbol	mmaA3
Gene Name	methoxy mycolic acid synthase 3 mmaA3
Location	737268 - 738149 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:882 bp Protein:294 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	13493
Related Genes	MT0671 MUL_0730
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0643c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0643c Transcript 1
MSDNSTGTTKSRSNVDDVQAHYDLSDAFFALFQDPTRTYSCAYFERDDMTLHEAQVAKLD
LTLGKLGLEPGMTLLDVGCGWGSVMKRAVERYDVNVVGLTLSKNQHAYCQQVLDKVDTNR
SHRVLLSDWANFSEPVDRIVTIEAIEHFGFERYDDFFKFAYNAMPADGVMLLHSITGLHV
KQVIERGIPLTMEMAKFIRFIVTDIFPGGRLPTIETIEEHVTKAGFTITDIQSLQPHFAR
TLDLWAEALQAHKDEAIEIQSAEVYERYMKYLTGCAKAFRMGYIDCNQFTLAK*

Genomic Sequence

>Rv0643c
ATGTCTGATAACTCAACGGGCACCACAAAGTCTCGGTCCAATGTCGACGACGTCCAAGCC
CATTACGACCTTTCAGATGCGTTCTTCGCGCTGTTCCAGGATCCGACTCGGACCTACAGC
TGCGCCTACTTCGAGCGCGACGACATGACCTTGCACGAAGCACAGGTCGCCAAGCTGGAC
CTAACCCTGGGCAAGCTGGGGCTAGAACCGGGAATGACACTGCTCGACGTGGGCTGCGGC
TGGGGTTCGGTCATGAAGCGTGCCGTCGAGCGCTACGACGTCAACGTCGTCGGCTTGACC
CTGTCGAAAAATCAGCACGCCTACTGCCAGCAAGTGCTCGACAAGGTCGACACCAACCGC
TCGCACCGGGTACTGCTGAGCGACTGGGCCAACTTCAGCGAGCCGGTGGACCGCATCGTA
ACCATCGAAGCGATAGAGCACTTCGGTTTCGAGCGCTACGATGACTTCTTCAAGTTCGCC
TACAACGCGATGCCCGCGGACGGCGTGATGCTGCTGCACTCGATCACCGGCTTGCACGTA
AAGCAGGTCATCGAGCGCGGCATACCGTTGACCATGGAGATGGCCAAATTCATCCGGTTC
ATCGTGACCGACATCTTCCCGGGCGGCCGGTTGCCGACGATCGAGACGATCGAGGAGCAT
GTGACGAAGGCCGGTTTCACCATTACCGATATCCAGTCCCTGCAACCGCACTTCGCCAGG
ACTCTTGACCTGTGGGCCGAGGCGCTTCAAGCGCACAAGGACGAGGCCATCGAGATCCAG
TCCGCAGAGGTATACGAGCGGTACATGAAATACCTGACCGGCTGCGCCAAGGCGTTCCGA
ATGGGCTACATCGACTGCAACCAGTTCACGCTGGCCAAGTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv2069	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Name	MmaA3 METHOXY MYCOLIC ACID SYNTHASE ; synthesis of methoxymycolates	active	mjackson	2012-10-05
	S-adenosyl-methionine-dependent mycolic acid methyltransferases
Term	EC:2.1.1.79 Cyclopropane-fatty-acyl-phospholipid synthase. - NR	active	extern:JZUCKER	2012-03-06
	Inferred from experiment Y. Yuan,Y. Zhu,DD. Crane,CE. Barry The effect of oxygenated mycolic acid composition on cell wall function and macrophage growth in Mycobacterium tuberculosis. Mol. Microbiol. 1998
Term	EC:2.1.1.- Transferases. Transferring one-carbon groups. Methyltransferases. - NR	active	extern:JZUCKER	2012-03-06
	Inferred from experiment Y. Yuan,Y. Zhu,DD. Crane,CE. Barry The effect of oxygenated mycolic acid composition on cell wall function and macrophage growth in Mycobacterium tuberculosis. Mol. Microbiol. 1998
Term	EC:2.1.1.- Transferases. Transferring one-carbon groups. Methyltransferases. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005