Rv0974c - acetyl-/propionyl-CoA carboxylase beta subunit accD2

Expression: Most Significant Conditions for Rv0974c

Protein Domains

Gene Information
Locus	Rv0974c
Symbol	accD2
Gene Name	acetyl-/propionyl-CoA carboxylase beta subunit accD2
Location	1085756 - 1087345 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1590 bp Protein:530 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	25740
Related Genes	MAP0912c MAV_1090 Mkms_4392 Mmcs_4306 MSMEG_5492 MT1002 MUL_4705 Mvan_4848 nfa53300 SAV3867
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0974c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0974c Transcript 1
MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDRHHARGNLTPRERIEL
LVDPDSPFLELSPLAAYGSNFQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRK
ILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMFRDLTRLSAAGIPTIALVFGN
STAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARISGLADY
FALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEELIGIVPPDLRIPFDPREVIA
RIVDGSEFDEFKPLYGSSLVTGWARLHGYPLGILANARGVLFSEESQKATQFIQLANRAD
TPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVPHISLLIGASYGAGHYGMCGR
AYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRAAVEGQIEA
ESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGTSNFGVFRM*

Genomic Sequence

>Rv0974c
GTGCTGCAATCCACACTGGACCCGAACGCTTCCGCCTACGACGAGGCGGCCGCGACGATG
AGCGGCAAGCTCGACGAGATCAACGCCGAACTGGCCAAGGCGCTCGCCGGCGGTGGCCCC
AAATACGTCGACCGGCACCACGCCCGCGGCAACCTGACACCACGGGAACGCATCGAGCTG
CTCGTCGACCCGGACTCCCCGTTCCTGGAGCTGAGCCCGCTGGCCGCCTACGGCAGCAAC
TTCCAGATCGGCGCCAGCCTGGTCACCGGCATCGGCGCGGTCTGCGGCGTGGAATGCATG
ATCGTCGCCAACGACCCGACGGTCAAGGGCGGCACCAGCAATCCGTGGACGCTTCGAAAG
ATACTGCGGGCCAACCAGATCGCCTTCGAAAACCGGCTTCCCGTCATTTCGCTGGTGGAA
TCCGGCGGGGCCGATCTGCCCACCCAGAAAGAGATTTTCATCCCCGGCGGACAGATGTTC
CGCGACCTGACCCGGCTGTCGGCGGCCGGGATCCCGACCATTGCGCTGGTTTTCGGCAAC
TCCACCGCGGGCGGTGCCTACGTCCCCGGCATGTCCGATCACGTGGTGATGATCAAGGAA
CGCTCCAAGGTGTTTTTGGCCGGCCCGCCGCTAGTGAAGATGGCCACCGGCGAAGAGTCC
GACGACGAGTCGCTGGGCGGCGCCGAAATGCACGCCCGCATATCGGGTTTGGCCGACTAT
TTTGCGCTCGACGAGCTCGACGCGATCCGCATCGGACGCCGCATCGTGGCGCGACTGAAC
TGGATCAAACAGGGACCCGCACCCGCTCCGGTGACCGAGCCGCTGTTCGACGCCGAGGAG
CTAATCGGCATCGTGCCCCCGGATCTGCGCATCCCATTCGACCCGCGCGAGGTGATCGCC
CGCATCGTCGATGGCTCCGAGTTCGACGAATTCAAGCCGCTGTACGGGTCGTCTCTGGTG
ACCGGCTGGGCTCGGTTGCACGGCTATCCGCTGGGCATCCTGGCCAACGCCCGCGGCGTG
CTGTTCAGCGAGGAATCACAGAAGGCCACCCAGTTCATCCAGCTGGCCAACCGGGCCGAC
ACGCCGCTGTTGTTCTTACACAACACCACCGGCTACATGGTGGGCAAGGACTACGAGGAA
GGCGGGATGATCAAGCATGGCTCGATGATGATCAACGCCGTGTCCAACTCGACCGTCCCG
CACATCTCGCTGCTGATCGGCGCGTCCTACGGCGCCGGGCACTACGGCATGTGCGGGCGC
GCCTACGACCCGCGCTTCCTATTCGCCTGGCCCAGCGCCAAGTCCGCGGTGATGGGCGGC
GCCCAGCTGTCGGGCGTGCTGTCCATCGTGGCCCGGGCGGCAGCCGAAGCCCGCGGGCAG
CAAGTCGACGAAGCCGCCGACGCGGCGATGCGGGCCGCCGTCGAGGGCCAGATCGAAGCC
GAGTCGCTACCGTTGGTGCTGTCCGGGATGCTTTACGACGACGGGGTGATCGACCCGCGC
GACACCCGCACCGTGCTGGGAATGTGTTTGTCCGCCATCGCCAATGGCCCGATCAAGGGG
ACGTCGAACTTCGGCGTCTTCCGGATGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv0616c	active	akankshajain.21	2012-10-05
	Co-expression (Functional linkage) T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
Interaction	RegulatedBy Rv0491	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
Name	Probable acetyl-/propionyl-CoA carboxylase (beta subunit)	active	mjackson	2012-10-05
	Claisen-type condensation
Term	EC:6.4.1.3 Propionyl-CoA carboxylase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
Term	EC:6.4.1.2 Acetyl-CoA carboxylase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011