Rv0982 - two component system sensor kinase mprB

Expression: Most Significant Conditions for Rv0982

Protein Domains

Gene Information
Locus	Rv0982
Symbol	mprB
Gene Name	two component system sensor kinase mprB
Location	1097508 - 1099022 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1515 bp Protein:505 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	35965
Related Genes	CE0949 cg0997 DIP0855 jk1531 MAP0917 MAV_1095 Mkms_4386 ML0175 Mmcs_4300 MSMEG_5487 MT1010 MUL_4700 Mvan_4843 nfa49630
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0982
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0982 Transcript 1
MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQ
SRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIR
GELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMNKLRWVLLIVGGIGVAVAAVA
GGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
ARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVG
DLVDLSRGDAGEVVHEPVDMADVVDRSLERVRRRRNDILFDVEVIGWQVYGDTAGLSRMA
LNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGIPVQERRLVFERFYRSASARA
LPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGAR
STDIENSRGSANVISVESQSTRAT*

Genomic Sequence

>Rv0982
ATGTGGTGGTTCCGCCGCCGAGACCGGGCGCCGCTGCGCGCCACCAGCTCATTATCCCTG
CGGTGGCGGGTCATGCTGCTGGCGATGTCCATGGTCGCGATGGTGGTTGTGCTGATGTCG
TTCGCCGTCTATGCGGTGATCTCGGCCGCGCTCTACAGCGACATCGACAACCAACTGCAG
AGCCGGGCGCAACTGCTCATCGCCAGTGGCTCGCTGGCAGCTGATCCGGGTAAGGCAATC
GAGGGTACCGCCTATTCGGATGTCAACGCGATGCTGGTCAACCCCGGCCAGTCCATCTAC
ACCGCTCAACAGCCGGGCCAGACGCTGCCGGTCGGTGCTGCCGAGAAGGCGGTGATCCGT
GGCGAGTTGTTCATGTCGCGGCGCACCACCGCCGACCAACGGGTGCTTGCCATCCGTCTG
ACCAACGGTAGTTCGCTGCTGATCTCCAAAAGTCTCAAGCCCACCGAAGCAGTCATGAAC
AAGCTGCGTTGGGTGCTATTGATCGTGGGTGGGATCGGGGTGGCGGTCGCCGCGGTGGCC
GGGGGGATGGTCACCCGGGCCGGGCTGAGGCCGGTGGGCCGCCTCACCGAAGCGGCCGAG
CGGGTGGCGCGAACCGACGACCTGCGGCCCATCCCCGTCTTCGGCAGCGACGAATTGGCC
AGGCTGACAGAGGCATTCAATTTAATGCTGCGGGCGCTGGCCGAGTCACGGGAACGGCAG
GCAAGGCTGGTTACCGACGCCGGACATGAATTGCGTACCCCGCTAACGTCGCTGCGCACC
AATGTCGAACTCTTGATGGCCTCGATGGCCCCGGGGGCTCCGCGGCTACCCAAGCAGGAG
ATGGTCGACCTGCGTGCCGATGTGCTGGCTCAAATCGAGGAATTGTCCACACTGGTAGGC
GATTTGGTGGACCTGTCCCGAGGCGACGCCGGAGAAGTGGTGCACGAGCCGGTCGACATG
GCTGACGTCGTCGACCGCAGCCTGGAGCGGGTCAGGCGGCGGCGCAACGATATCCTTTTC
GACGTCGAGGTGATTGGGTGGCAGGTTTATGGCGATACCGCTGGATTGTCGCGGATGGCG
CTTAACCTGATGGACAACGCCGCGAAGTGGAGCCCGCCGGGCGGCCACGTGGGTGTCAGG
CTGAGCCAGCTCGACGCGTCGCACGCTGAGCTGGTGGTTTCCGACCGCGGCCCGGGCATT
CCCGTGCAGGAGCGCCGTCTGGTGTTTGAACGGTTTTACCGGTCGGCATCGGCACGGGCG
TTGCCGGGTTCGGGCCTCGGGTTGGCGATCGTCAAACAGGTGGTGCTCAACCACGGCGGA
TTGCTGCGCATCGAAGACACCGACCCAGGCGGCCAGCCCCCTGGAACGTCGATTTACGTG
CTGCTCCCCGGCCGTCGGATGCCGATTCCGCAGCTTCCCGGTGCGACGGCTGGCGCTCGG
AGCACGGACATCGAGAACTCTCGGGGTTCGGCGAACGTTATCTCAGTGGAATCTCAGTCC
ACGCGCGCAACCTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Activation Rv2984	active	kholia.trupti	2012-10-05
	Affinity purification (Physical interaction) K. Sureka, S. Dey et al. Polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteria. Mol. Microbiol. 2007
Interaction	Activation Rv2984	active	kholia.trupti	2012-10-05
	Affinity purification (Physical interaction) A. Kornberg, NN. Rao et al. Inorganic polyphosphate: a molecule of many functions. Annu. Rev. Biochem. 1999
Interaction	Regulatory Rv2710	active	priyadarshinipriyanka2001	2012-10-05
	Band Shift H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Interaction	Regulatory Rv1221	active	priyadarshinipriyanka2001	2012-10-05
	Band Shift H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Interaction	Signaling Rv0981	active	ahal4789	2012-10-05
	Affinity purification(physical interaction) H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Interaction	Signaling Rv0981	active	ahal4789	2012-10-05
	Affinity purification(physical interaction) TC. Zahrt, C. Wozniak et al. Functional analysis of the Mycobacterium tuberculosis MprAB two-component signal transduction system. Infect. Immun. 2003
Interaction	Regulatory Rv0981	active	ahal4789	2012-10-05
	Affinity purification(physical interaction) H. He & TC. Zahrt Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA. J. Bacteriol. 2005
Interaction	Regulatory Rv0981	active	ahal4789	2012-10-05
	Affinity purification(physical interaction) H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Interaction	Regulatory Rv0981	active	ahal4789	2012-10-05
	Affinity purification(physical interaction) TC. Zahrt, C. Wozniak et al. Functional analysis of the Mycobacterium tuberculosis MprAB two-component signal transduction system. Infect. Immun. 2003
Interaction	RegulatedBy Rv1221	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001