Rv0983 - serine protease pepD

Expression: Most Significant Conditions for Rv0983

Protein Domains

Gene Information
Locus	Rv0983
Symbol	pepD
Gene Name	serine protease pepD
Location	1099066 - 1100460 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1395 bp Protein:465 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	33776
Related Genes	Acel_1593 BL0555 CE0950 cg0998 DIP0856 jk1530 MAP0918 MAV_1096 Mkms_4385 ML0176 Mmcs_4299 MSMEG_5486 MT1011 MUL_4699 Mvan_4842 nfa49620 PPA2307 SAV4045
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0983
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0983 Transcript 1
MAKLARVVGLVQEEQPSDMTNHPRYSPPPQQPGTPGYAQGQQQTYSQQFDWRYPPSPPPQ
PTQYRQPYEALGGTRPGLIPGVIPTMTPPPGMVRQRPRAGMLAIGAVTIAVVSAGIGGAA
ASLVGFNRAPAGPSGGPVAASAAPSIPAANMPPGSVEQVAAKVVPSVVMLETDLGRQSEE
GSGIILSAEGLILTNNHVIAAAAKPPLGSPPPKTTVTFSDGRTAPFTVVGADPTSDIAVV
RVQGVSGLTPISLGSSSDLRVGQPVLAIGSPLGLEGTVTTGIVSALNRPVSTTGEAGNQN
TVLDAIQTDAAINPGNSGGALVNMNAQLVGVNSAIATLGADSADAQSGSIGLGFAIPVDQ
AKRIADELISTGKASHASLGVQVTNDKDTLGAKIVEVVAGGAAANAGVPKGVVVTKVDDR
PINSADALVAAVRSKAPGATVALTFQDPSGGSRTVQVTLGKAEQ*

Genomic Sequence

>Rv0983
ATGGCCAAGTTGGCCCGAGTAGTGGGCCTAGTACAGGAAGAGCAACCTAGCGACATGACG
AATCACCCACGGTATTCGCCACCGCCGCAGCAGCCGGGAACCCCAGGTTATGCTCAGGGG
CAGCAGCAAACGTACAGCCAGCAGTTCGACTGGCGTTACCCACCGTCCCCGCCCCCGCAG
CCAACCCAGTACCGTCAACCCTACGAGGCGTTGGGTGGTACCCGGCCGGGTCTGATACCT
GGCGTGATTCCGACCATGACGCCCCCTCCTGGGATGGTTCGCCAACGCCCTCGTGCAGGC
ATGTTGGCCATCGGCGCGGTGACGATAGCGGTGGTGTCCGCCGGCATCGGCGGCGCGGCC
GCATCCCTGGTCGGGTTCAACCGGGCACCCGCCGGCCCCAGCGGCGGCCCAGTGGCTGCC
AGCGCGGCGCCAAGCATCCCCGCAGCAAACATGCCGCCGGGGTCGGTCGAACAGGTGGCG
GCCAAGGTGGTGCCCAGTGTCGTCATGTTGGAAACCGATCTGGGCCGCCAGTCGGAGGAG
GGCTCCGGCATCATTCTGTCTGCCGAGGGGCTGATCTTGACCAACAACCACGTGATCGCG
GCGGCCGCCAAGCCTCCCCTGGGCAGTCCGCCGCCGAAAACGACGGTAACCTTCTCTGAC
GGGCGGACCGCACCCTTCACGGTGGTGGGGGCTGACCCCACCAGTGATATCGCCGTCGTC
CGTGTTCAGGGCGTCTCCGGGCTCACCCCGATCTCCCTGGGTTCCTCCTCGGACCTGAGG
GTCGGTCAGCCGGTGCTGGCGATCGGGTCGCCGCTCGGTTTGGAGGGCACCGTGACCACG
GGGATCGTCAGCGCTCTCAACCGTCCAGTGTCGACGACCGGCGAGGCCGGCAACCAGAAC
ACCGTGCTGGACGCCATTCAGACCGACGCCGCGATCAACCCCGGTAACTCCGGGGGCGCG
CTGGTGAACATGAACGCTCAACTCGTCGGAGTCAACTCGGCCATTGCCACGCTGGGCGCG
GACTCAGCCGATGCGCAGAGCGGCTCGATCGGTCTCGGTTTTGCGATTCCAGTCGACCAG
GCCAAGCGCATCGCCGACGAGTTGATCAGCACCGGCAAGGCGTCACATGCCTCCCTGGGT
GTGCAGGTGACCAATGACAAAGACACCCTGGGCGCCAAGATCGTCGAAGTAGTGGCCGGT
GGTGCTGCCGCGAACGCTGGAGTGCCGAAGGGCGTCGTTGTCACCAAGGTCGACGACCGC
CCGATCAACAGCGCGGACGCGTTGGTTGCCGCCGTGCGGTCCAAAGCGCCGGGCGCCACG
GTGGCGCTAACCTTTCAGGATCCCTCGGGCGGTAGCCGCACAGTGCAAGTCACCCTCGGC
AAGGCGGAGCAGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv0981	active	ahal4789	2012-10-05
	Band shift H. He & TC. Zahrt Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA. J. Bacteriol. 2005
Interaction	Regulatory Rv0981	active	ahal4789	2012-10-05
	Band shift MJ. White, H. He et al. PepD participates in the mycobacterial stress response mediated through MprAB and SigE. J. Bacteriol. 2010
Interaction	Regulatory Rv0981	active	ahal4789	2012-10-05
	Affinity purification(physical interaction) H. He & TC. Zahrt Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA. J. Bacteriol. 2005
Interaction	Regulatory Rv0981	active	ahal4789	2012-10-05
	Affinity purification(physical interaction) H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Interaction	Regulatory Rv0981	active	ahal4789	2012-10-05
	Affinity purification(physical interaction) TC. Zahrt, C. Wozniak et al. Functional analysis of the Mycobacterium tuberculosis MprAB two-component signal transduction system. Infect. Immun. 2003
Interaction	RegulatedBy Rv1221	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
Interaction	RegulatedBy Rv0981	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008