Rv1082 - mycothiol conjugate amidase mca


Protein Domains

Gene Information
LocusRv1082
Symbolmca
Gene Namemycothiol conjugate amidase mca
Location1206520 - 1207386 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:867 bp
Protein:289 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number13883
Related GenesAcel_1886 CE1052 cg1127 DIP0927 jk1469 MAP1029 MAV_1206 Mkms_4217 ML2391 Mmcs_4142 MSMEG_5261 MT1113 MUL_0198 Mvan_4667 nfa48240 SAV3299
Transcriptional Regulation
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Regulatory Network
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Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
TermTBRXN:MSHAMID conjugated glutathione amidase (Mtb) - ISSactivenjamshidi2012-10-05
See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction.
M. Steffek, GL. Newton et al. Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase. Biochemistry 2003
TermTBRXN:MSHAMID conjugated glutathione amidase (Mtb) - ISSactivenjamshidi2012-10-05
See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction.
GL. Newton, Y. Av-Gay et al. A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase. Biochemistry 2000
TermTBRXN:MSHAMID conjugated glutathione amidase (Mtb) - ISSactivenjamshidi2012-10-05
See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction.
GL. Newton & RC. Fahey Mycothiol biochemistry. Arch. Microbiol. 2002
TermTBRXN:MSHAMID conjugated glutathione amidase (Mtb) - IDAactivenjamshidi2012-10-05
See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction.
M. Steffek, GL. Newton et al. Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase. Biochemistry 2003
TermTBRXN:MSHAMID conjugated glutathione amidase (Mtb) - IDAactivenjamshidi2012-10-05
See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction.
GL. Newton, Y. Av-Gay et al. A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase. Biochemistry 2000
TermTBRXN:MSHAMID conjugated glutathione amidase (Mtb) - IDAactivenjamshidi2012-10-05
See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction.
GL. Newton & RC. Fahey Mycothiol biochemistry. Arch. Microbiol. 2002