Rv1266c - transmembrane serine/threonine-protein kinase H pknH

Expression: Most Significant Conditions for Rv1266c

Protein Domains

Gene Information
Locus	Rv1266c
Symbol	pknH
Gene Name	transmembrane serine/threonine-protein kinase H pknH
Location	1413960 - 1415840 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1881 bp Protein:627 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	36990
Related Genes	MAP2504 MAV_1417 MT1304
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1266c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1266c Transcript 1
MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAEFSKDPVFRER
MKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTDLDSVLKRFGPLTPPRAVAII
TQIASALDAAHADGVMHRDVKPQNILITRDDFAYLVDFGIASATTDEKLTQLGTAVGTWK
YMAPERFSNDEVTYRADIYALACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRP
GIPKAFDAVVARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPAPP
KPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKPSYTPPAQPGPAGQRPGPTGQPSWAPN
SGPMPASGPTPTPQYYQGGGWGAPPSGGPSPWAQTPRKTNPWPLVAGAAAVVLVLVLGAI
GIWIAIRPKPVQPPQPVAEERLSALLLNSSEVNAVMGSSSMQPGKPITSMDSSPVTVSLP
DCQGALYTSQDPVYAGTGYTAINGLISSEPGDNYEHWVNQAVVAFPTADKARAFVQTSAD
KWKNCAGKTVTVTNKAKTYRWTFADVKGSPPTITVIDTQEGAEGWECQRAMSVANNVVVD
VNACGYRITNQAGQIAAKIVDKVNKE*

Genomic Sequence

>Rv1266c
ATGAGCGACGCACAGGACTCGCGGGTGGGCTCGATGTTTGGGCCCTACCACCTCAAACGG
CTGTTGGGCCGGGGCGGGATGGGCGAGGTCTACGAGGCCGAGCACACCGTCAAGGAGTGG
ACCGTCGCCGTCAAGCTGATGACCGCGGAATTCAGCAAGGACCCGGTGTTTCGCGAGCGG
ATGAAACGCGAAGCCCGCATCGCCGGCCGGTTGCAGGAACCTCACGTGGTGCCCATCCAC
GACTACGGCGAAGTCGACGGCCAAATGTTTTTGGAGATGCGCCTGGTGGAGGGCACCGAC
CTTGACAGCGTGCTCAAACGCTTCGGCCCGCTGACCCCACCGCGCGCGGTGGCCATCATC
ACCCAGATCGCCTCGGCGCTCGATGCCGCACACGCCGACGGGGTGATGCACCGCGACGTC
AAACCGCAAAACATTCTGATCACCCGCGACGACTTTGCCTATCTGGTCGACTTCGGGATC
GCCAGTGCGACCACCGACGAGAAACTGACCCAGTTAGGCACCGCGGTGGGCACCTGGAAA
TACATGGCCCCCGAACGGTTCTCCAACGACGAGGTAACCTACCGCGCCGACATCTACGCG
CTGGCCTGCGTGCTGCACGAATGCTTGACCGGGGCCCCGCCGTATCGCGCCGACAGCGCC
GGCACACTGGTCAGCTCCCACCTGATGGGACCCATCCCCCAGCCCAGCGCCATCCGCCCG
GGCATCCCCAAAGCCTTTGACGCGGTGGTCGCCCGCGGCATGGCCAAAAAGCCCGAAGAC
CGCTACGCCAGCGCCGGCGACCTGGCCCTGGCCGCCCACGAAGCGCTCAGCGACCCCGAC
CAAGACCACGCCGCCGACATCCTGCGCCGCAGCCAAGAATCCACCCTGCCCGCGCCGCCT
AAGCCCGTCCCGCCTCCGACCATGCCGGCCACCGCCATGGCTCCTCGGCAGCCACCCGCA
CCCCCCGTCACCCCGCCGGGTGTCCAGCCGGCACCAAAGCCGTCCTACACGCCCCCGGCC
CAGCCGGGGCCTGCCGGACAGCGGCCTGGCCCCACCGGCCAGCCGTCCTGGGCGCCCAAT
AGCGGCCCGATGCCGGCCAGCGGACCCACTCCCACCCCGCAGTACTACCAGGGCGGCGGC
TGGGGCGCACCGCCGTCCGGCGGCCCCAGCCCCTGGGCCCAGACCCCGCGCAAAACCAAC
CCGTGGCCCTTAGTGGCCGGCGCCGCCGCCGTCGTGCTCGTCCTCGTGTTGGGCGCCATC
GGCATCTGGATCGCCATCCGGCCCAAGCCGGTACAGCCGCCTCAGCCGGTTGCGGAGGAG
CGCCTTAGCGCCCTACTGCTGAACTCCTCAGAAGTCAACGCCGTGATGGGCTCGTCGTCC
ATGCAGCCGGGCAAACCGATCACATCGATGGACTCTTCGCCGGTGACGGTGTCCCTGCCG
GACTGCCAGGGCGCGCTGTATACCAGCCAGGATCCGGTGTATGCCGGCACCGGCTACACC
GCCATCAACGGCTTGATTTCATCCGAGCCGGGCGACAACTACGAACATTGGGTGAACCAA
GCCGTCGTCGCCTTTCCGACCGCCGACAAAGCCCGCGCGTTCGTGCAGACTTCGGCCGAC
AAATGGAAGAACTGCGCAGGCAAGACGGTCACCGTCACGAATAAGGCCAAGACCTACCGG
TGGACGTTTGCCGACGTCAAAGGCAGCCCGCCGACGATCACGGTGATAGACACCCAAGAA
GGCGCTGAGGGCTGGGAATGCCAACGCGCGATGAGCGTGGCCAACAATGTGGTCGTCGAC
GTCAACGCATGCGGGTACCGGATCACCAATCAAGCAGGCCAGATCGCCGCCAAGATCGTT
GACAAAGTCAACAAGGAATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Signaling Rv3330	active	jhum4u2006	2012-10-05
	Structural Analysis X. Zheng, KG. Papavinasasundaram et al. Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Biochem. Biophys. Res. Commun. 2007
Interaction	Signaling Rv3330	active	jhum4u2006	2012-10-05
	Spectrophotometric X. Zheng, KG. Papavinasasundaram et al. Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Biochem. Biophys. Res. Commun. 2007
Interaction	Signaling Rv3330	active	hibeeluck	2012-10-05
	Structural Analysis X. Zheng, KG. Papavinasasundaram et al. Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Biochem. Biophys. Res. Commun. 2007
Interaction	Signaling Rv3330	active	hibeeluck	2012-10-05
	Spectrophotometric X. Zheng, KG. Papavinasasundaram et al. Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Biochem. Biophys. Res. Commun. 2007
Interaction	Signaling Rv2133c	active	akankshajain.21	2012-10-05
	Co-occurance (Functional Linkage) authors,MA. Krasilnikov Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation. Biochemistry Mosc. 2000
Interaction	Signaling Rv1267c	active	shruti4rana	2012-10-05
	Structural Analysis K. Sharma, M. Gupta et al. Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo. J. Bacteriol. 2006
Interaction	Signaling Rv1267c	active	shruti4rana	2012-10-05
	Structural Analysis LJ. Alderwick, V. Molle et al. Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2006
Interaction	Regulatory Rv3793	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) K. Sharma, M. Gupta et al. Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo. J. Bacteriol. 2006
Interaction	Regulatory Rv3795	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) K. Sharma, M. Gupta et al. Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo. J. Bacteriol. 2006
Interaction	Regulatory Rv3794	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) K. Sharma, M. Gupta et al. Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo. J. Bacteriol. 2006
Interaction	Activation Rv1267c	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) K. Sharma, M. Gupta et al. Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo. J. Bacteriol. 2006
Interaction	Signaling Rv0681	active	sudhakar_dipu	2012-10-05
	Structural Analysis X. Zheng, KG. Papavinasasundaram et al. Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Biochem. Biophys. Res. Commun. 2007
Interaction	Signaling Rv0681	active	sudhakar_dipu	2012-10-05
	Spectrophotometric X. Zheng, KG. Papavinasasundaram et al. Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Biochem. Biophys. Res. Commun. 2007
Interaction	Regulates Rv1267c	active	yamir.moreno	2012-10-05
	qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique. K. Sharma, M. Gupta et al. Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo. J. Bacteriol. 2006
Interaction	Regulates Rv1267c	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Name	TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE, known to phosphorylate InhA;KasA, KasB	active	mjackson	2012-10-05
	Regulatory proteins
Interaction	Signaling Rv3330	active	jhum4u2006	2012-10-03
	Structural Analysis X. Zheng, KG. Papavinasasundaram et al. Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Biochem. Biophys. Res. Commun. 2007
Interaction	Signaling Rv3330	active	jhum4u2006	2012-10-03
	Spectrophotometric X. Zheng, KG. Papavinasasundaram et al. Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Biochem. Biophys. Res. Commun. 2007