Rv1326c - 1,4-alpha-glucan branching enzyme glgB

Expression: Most Significant Conditions for Rv1326c

Protein Domains

Gene Information
Locus	Rv1326c
Symbol	glgB
Gene Name	1,4-alpha-glucan branching enzyme glgB
Location	1490117 - 1492312 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:2196 bp Protein:732 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	32877
Related Genes	Acel_0676 BL0999 CE1323 cg1381 DIP1065 jk1330 MAP2434 Mkms_3935 Mmcs_3861 MSMEG_4918 MT1368 MUL_3936 Mvan_4302 nfa10780 PPA1111 SAV2805
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1326c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1326c Transcript 1
MSRSEKLTGEHLAPEPAEMARLVAGTHHNPHGILGAHEYDDHTVIRAFRPHAVEVVALVG
KDRFSLQHLDSGLFAVALPFVDLIDYRLQVTYEGCEPHTVADAYRFLPTLGEVDLHLFAE
GRHERLWEVLGAHPRSFTTADGVVSGVSFAVWAPNAKGVSLIGEFNGWNGHEAPMRVLGP
SGVWELFWPDFPCDGLYKFRVHGADGVVTDRADPFAFGTEVPPQTASRVTSSDYTWGDDD
WMAGRALRNPVNEAMSTYEVHLGSWRPGLSYRQLARELTDYIVDQGFTHVELLPVAEHPF
AGSWGYQVTSYYAPTSRFGTPDDFRALVDALHQAGIGVIVDWVPAHFPKDAWALGRFDGT
PLYEHSDPKRGEQLDWGTYVFDFGRPEVRNFLVANALYWLQEFHIDGLRVDAVASMLYLD
YSRPEGGWTPNVHGGRENLEAVQFLQEMNATAHKVAPGIVTIAEESTPWSGVTRPTNIGG
LGFSMKWNMGWMHDTLDYVSRDPVYRSYHHHEMTFSMLYAFSENYVLPLSHDEVVHGKGT
LWGRMPGNNHVKAAGLRSLLAYQWAHPGKQLLFMGQEFGQRAEWSEQRGLDWFQLDENGF
SNGIQRLVRDINDIYRCHPALWSLDTTPEGYSWIDANDSANNVLSFMRYGSDGSVLACVF
NFAGAEHRDYRLGLPRAGRWREVLNTDATIYHGSGIGNLGGVDATDDPWHGRPASAVLVL
PPTSALWLTPA*

Genomic Sequence

>Rv1326c
ATGAGTCGATCCGAGAAACTCACCGGGGAGCACCTTGCACCCGAGCCGGCCGAAATGGCG
CGCTTGGTGGCGGGTACACATCACAACCCGCACGGCATCCTGGGCGCCCACGAATACGAC
GACCATACCGTCATCCGAGCGTTCCGTCCGCATGCCGTCGAGGTCGTCGCGCTCGTTGGT
AAGGACCGGTTCTCGTTGCAGCACCTCGATTCTGGCCTGTTTGCCGTCGCATTGCCGTTC
GTCGACCTCATCGACTACCGCCTGCAGGTGACCTATGAAGGTTGCGAGCCACACACCGTG
GCCGATGCGTACCGATTCCTGCCCACCCTGGGCGAGGTCGACCTGCACCTGTTCGCCGAG
GGCCGCCACGAACGGCTTTGGGAAGTCCTGGGTGCCCACCCCCGCTCGTTTACCACGGCC
GACGGTGTGGTGAGTGGCGTGTCGTTCGCCGTGTGGGCGCCCAACGCCAAGGGCGTCAGC
TTGATCGGCGAGTTCAACGGTTGGAATGGCCACGAAGCCCCCATGCGGGTGCTCGGCCCA
TCAGGGGTATGGGAATTGTTCTGGCCCGACTTCCCTTGCGACGGTCTGTACAAGTTCCGC
GTGCACGGCGCCGACGGCGTGGTTACCGATCGGGCCGACCCGTTCGCGTTCGGCACCGAG
GTGCCGCCGCAGACCGCATCGCGGGTGACGTCGAGTGACTACACCTGGGGTGACGACGAC
TGGATGGCTGGGCGTGCGCTGCGCAACCCGGTGAACGAGGCGATGAGCACCTACGAAGTC
CATCTCGGTTCGTGGCGGCCTGGACTCAGCTACCGCCAGCTTGCTCGTGAGTTGACGGAT
TACATTGTGGATCAAGGGTTTACCCATGTGGAGCTGTTGCCCGTCGCCGAGCATCCATTC
GCCGGATCATGGGGGTATCAGGTCACGTCCTACTATGCGCCGACATCACGATTCGGCACA
CCCGACGACTTCCGGGCGCTGGTCGACGCCCTGCACCAGGCCGGCATCGGCGTCATCGTG
GATTGGGTCCCAGCGCACTTCCCGAAGGACGCGTGGGCCCTGGGACGGTTCGACGGCACT
CCGCTCTACGAACATTCCGATCCCAAACGCGGCGAGCAACTGGATTGGGGCACATACGTG
TTCGACTTCGGCCGCCCGGAAGTGCGCAACTTTCTGGTAGCCAATGCGTTGTACTGGCTA
CAGGAGTTCCACATCGACGGCCTGCGGGTGGACGCGGTGGCCTCAATGCTCTATCTAGAC
TACTCGCGACCCGAGGGCGGCTGGACCCCCAACGTCCACGGCGGCCGGGAGAACCTGGAA
GCAGTGCAGTTCCTGCAGGAGATGAACGCCACGGCGCACAAGGTCGCGCCGGGAATCGTC
ACCATCGCCGAGGAGTCCACGCCGTGGTCTGGGGTGACCCGCCCGACCAACATTGGCGGC
CTGGGCTTTTCGATGAAGTGGAACATGGGCTGGATGCACGACACGCTCGACTACGTCAGC
CGAGATCCGGTGTACCGCAGCTACCACCACCACGAGATGACGTTCTCGATGCTGTATGCG
TTCAGCGAAAATTACGTGTTGCCGCTCAGTCATGACGAGGTGGTGCACGGCAAAGGCACG
CTGTGGGGGCGGATGCCGGGCAACAATCACGTCAAGGCCGCCGGCCTGCGTAGCCTGCTT
GCCTACCAATGGGCACACCCCGGCAAGCAATTGCTGTTCATGGGTCAGGAATTCGGCCAA
CGCGCCGAATGGTCCGAGCAGCGCGGCCTGGACTGGTTCCAACTCGACGAAAACGGCTTC
TCCAACGGGATTCAGCGGCTGGTGCGCGACATCAACGACATCTACCGATGCCACCCGGCG
CTGTGGAGCTTAGACACCACCCCCGAAGGCTATTCTTGGATCGACGCCAACGACTCCGCC
AACAATGTGTTGAGCTTTATGCGCTACGGCAGCGACGGCTCGGTGCTGGCCTGCGTGTTC
AATTTCGCAGGTGCCGAACACCGTGACTATCGACTCGGGCTGCCGCGCGCGGGCCGCTGG
CGCGAGGTGCTCAATACCGACGCGACGATCTACCACGGCTCAGGGATCGGCAACCTCGGC
GGCGTGGACGCCACCGACGACCCCTGGCATGGCCGCCCGGCGTCCGCGGTGCTGGTGCTG
CCGCCCACTTCGGCGCTGTGGCTGACGCCCGCCTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv3219	active	sourish10	2012-10-05
	Yeast two-hybrid (Physical interaction) SK. Garg, MS. Alam et al. Redox Biology of Mycobacterium tuberculosis H37Rv: protein-protein interaction between GlgB and WhiB1 involves exchange of thiol-disulfide. BMC Biochem. 2009
Interaction	PhysicalInteraction Rv3219	active	ahal4789	2012-10-05
	Yeast two-hybrid (Physical interaction) SK. Garg, MS. Alam et al. Redox Biology of Mycobacterium tuberculosis H37Rv: protein-protein interaction between GlgB and WhiB1 involves exchange of thiol-disulfide. BMC Biochem. 2009
Name	alpha-1,4-glucan branching enzyme	active	mjackson	2012-10-05
	Other (lipo)polysaccharides [Methylglucose lipolysaccharides, glycogen and capsular alpha-1,4 glucan]
Name	alpha-1,4-glucan branching enzyme	active	mjackson	2012-10-05
	Other (lipo)polysaccharides [Methylglucose lipolysaccharides, glycogen and capsular alpha-1,4 glucan]
Other	TBPWY:(MGLP and alpha-1,4 glucans)	active	mjackson	2012-03-05
	alpha-1,4-glucan branching enzyme (phenotypic [mycobacterial recombinant strains]; enzymatic) R. Kalscheuer,K. Syson,U. Veeraraghavan,B. Weinrick,KE. Biermann,Z. Liu,JC. Sacchettini,G. Besra,S. Bornemann,WR. Jacobs Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway. Nature chemical biology 2010
Other	TBPWY:(MGLP and alpha-1,4 glucans)	active	mjackson	2012-03-05
	alpha-1,4-glucan branching enzyme (phenotypic [mycobacterial recombinant strains]; enzymatic) T. Sambou, P. Dinadayala et al. Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice. Mol. Microbiol. 2008
Other	TBPWY:(MGLP and alpha-1,4 glucans)	active	mjackson	2012-03-05
	alpha-1,4-glucan branching enzyme (phenotypic [mycobacterial recombinant strains]; enzymatic) SK. Garg, MS. Alam et al. Expression and characterization of alpha-(1,4)-glucan branching enzyme Rv1326c of Mycobacterium tuberculosis H37Rv. Protein Expr. Purif. 2007