Rv1381 - dihydroorotase pyrC

Expression: Most Significant Conditions for Rv1381

Protein Domains

Gene Information
Locus	Rv1381
Symbol	pyrC
Gene Name	dihydroorotase pyrC
Location	1554188 - 1555480 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1293 bp Protein:431 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	32731
Related Genes	Acel_1300 BL0792 CE1731 cg1815 DIP1333 jk1024 MAP1116 MAV_3392 Mkms_2411 ML0533 Mmcs_2364 MSMEG_3044 MT1425 MUL_1781 Mvan_2661 nfa36220 PPA0998 SAV6864
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1381
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1381 Transcript 1
MSVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDATGHVLLPGFVDLHTHL
REPGREYAEDIETGSAAAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPV
GAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLIMRRALEYATGLGVLIAQHAE
EPRLTVGAVAHEGPMAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEI
LKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALRQALADGIIDC
VATDHAPHAEHEKCVEFAAARPGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACI
ARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSANTPFESMSLPATVTATLLRGK
VTARDGKIRA*

Genomic Sequence

>Rv1381
GTGAGCGTGCTGATTCGTGGTGTGCGGCCCTACGGCGAGGGGGAGCGGGTCGACGTACTC
GTCGATGACGGCCAGATCGCCCAGATAGGACCGGATCTGGCGATCCCCGATACGGCCGAT
GTCATTGACGCCACCGGACACGTGCTGCTGCCCGGGTTCGTCGATCTGCACACCCATCTG
CGCGAGCCGGGCCGCGAGTATGCCGAGGACATCGAAACCGGTTCGGCCGCGGCCGCTTTG
GGCGGCTACACCGCGGTGTTCGCGATGGCCAACACCAACCCCGTGGCCGACAGCCCGGTG
GTCACCGACCACGTCTGGCACCGCGGCCAGCAGGTCGGCCTGGTCGACGTGCACCCCGTC
GGCGCGGTCACCGTCGGGCTGGCCGGAGCCGAGCTGACCGAGATGGGCATGATGAACGCC
GGCGCCGCCCAGGTGCGGATGTTCTCCGACGACGGGGTCTGCGTGCATGACCCGCTGATC
ATGCGCCGCGCCCTGGAATATGCCACCGGTTTGGGCGTGCTGATCGCCCAGCACGCCGAG
GAGCCCCGGCTGACGGTCGGCGCCGTCGCGCACGAGGGACCCATGGCGGCGCGGCTGGGC
CTGGCGGGATGGCCGCGGGCCGCCGAGGAATCGATCGTCGCCCGCGACGCCTTGCTGGCC
CGTGACGCCGGCGCCCGGGTGCACATCTGTCACGCGTCGGCCGCGGGCACCGTCGAAATC
CTGAAATGGGCTAAGGACCAGGGTATTTCGATCACCGCCGAGGTCACCCCCCACCACCTG
TTGCTCGACGATGCCAGATTGGCCAGCTATGACGGCGTGAACCGGGTCAACCCGCCGCTG
CGCGAAGCTTCCGACGCGGTCGCCCTGCGACAGGCGCTGGCCGACGGGATCATCGACTGT
GTGGCCACAGATCACGCCCCGCATGCCGAGCACGAGAAATGCGTCGAATTCGCCGCGGCC
CGGCCCGGCATGCTCGGGTTGCAGACGGCATTGTCGGTGGTGGTGCAGACAATGGTGGCG
CCCGGCTTGTTGAGTTGGCGCGATATCGCGCGGGTGATGAGTGAGAACCCGGCGTGCATC
GCACGCTTGCCCGATCAGGGCCGGCCACTGGAGGTGGGGGAGCCGGCCAACCTGACGGTG
GTGGACCCCGACGCCACCTGGACGGTCACCGGCGCCGACCTGGCCAGCCGGTCGGCCAAC
ACGCCGTTTGAGTCGATGAGCCTGCCCGCCACCGTGACCGCGACCCTGCTGCGCGGGAAG
GTGACCGCGCGCGACGGGAAGATCCGGGCATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv1379	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) authors,CJ. Fields,RL. Switzer Regulation of pyr gene expression in Mycobacterium smegmatis by PyrR-dependent translational repression. J. Bacteriol. 2007
Interaction	Regulatory Rv1379	active	shahanup86	2012-10-05
	Structural Analysis authors,CJ. Fields,RL. Switzer Regulation of pyr gene expression in Mycobacterium smegmatis by PyrR-dependent translational repression. J. Bacteriol. 2007
Interaction	Regulatory Rv1379	active	shahanup86	2012-10-05
	Structural Analysis KA. Kantardjieff, C. Vasquez et al. Structure of pyrR (Rv1379) from Mycobacterium tuberculosis: a persistence gene and protein drug target. Acta Crystallogr. D Biol. Crystallogr. 2005
Interaction	Regulatory Rv1379	active	shahanup86	2012-10-05
	Spectrophotometric authors,CJ. Fields,RL. Switzer Regulation of pyr gene expression in Mycobacterium smegmatis by PyrR-dependent translational repression. J. Bacteriol. 2007
Interaction	Regulatory Rv1379	active	shahanup86	2012-10-05
	Spectrophotometric KA. Kantardjieff, C. Vasquez et al. Structure of pyrR (Rv1379) from Mycobacterium tuberculosis: a persistence gene and protein drug target. Acta Crystallogr. D Biol. Crystallogr. 2005
Interaction	RegulatedBy Rv1379	active	yamir.moreno	2012-10-05
	Protein structure based inferences. the regulation is infered after the observation of protein structure. KA. Kantardjieff, C. Vasquez et al. Structure of pyrR (Rv1379) from Mycobacterium tuberculosis: a persistence gene and protein drug target. Acta Crystallogr. D Biol. Crystallogr. 2005