Rv1387 - PPE family protein

Expression: Most Significant Conditions for Rv1387

Protein Domains

Gene Information
Locus	Rv1387
Symbol	PPE20
Gene Name	PPE family protein
Location	1561769 - 1563388 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1620 bp Protein:540 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	12645
Related Genes	MAP0123 ML0539 MT1431
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1387
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1387 Transcript 1
MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQYAEAASEVEELLGVVASEGWQ
GQAAEAFVAAYMPFLAWLIQASADCVEMAAQQHVVIEAYTAAVELMPTQVELAANQIKLA
VLVATNFFGINTIPIAINEAEYVEMWVRAATTMATYSTVSRSALSAMPHTSPPPLILKSD
ELLPDTGEDSDEDGHNHGGHSHGGHARMIDNFFAEILRGVSAGRIVWDPVNGTLNGLDYD
DYVYPGHAIWWLARGLEFFQDGEQFGELLFTNPTGAFQFLLYVVVVDLPTHIAQIATWLG
QYPQLLSAALTGVIAHLGAITGLAGLSGLSAIPSAAIPAVVPELTPVAAAPPMLAVAGVG
PAVAAPGMLPASAPAPAAAAGATAAGPTPPATGFGGFPPYLVGGGGPGIGFGSGQSAHAK
AAASDSAAAESAAQASARAQARAARRGRSAAKARGHRDEFVTMDMGFDAAAPAPEHQPGA
RASDCGAGPIGFAGTVRKEAVVKAAGLTTLAGDDFGGGPTMPMMPGTWTHDQGVFDEHR*

Genomic Sequence

>Rv1387
ATGACCGAGCCGTGGATAGCCTTCCCTCCCGAGGTGCACTCGGCGATGCTGAACTACGGT
GCGGGCGTTGGGCCGATGTTGATCTCCGCCACGCAGAATGGGGAGCTCAGCGCCCAATAC
GCAGAAGCGGCATCAGAGGTCGAGGAATTGTTGGGGGTGGTGGCCTCCGAGGGATGGCAG
GGGCAAGCCGCCGAGGCGTTTGTCGCCGCGTACATGCCGTTTCTGGCGTGGCTGATCCAA
GCCAGCGCCGACTGCGTGGAAATGGCCGCCCAGCAACACGTCGTCATCGAGGCCTACACT
GCCGCGGTAGAGCTGATGCCTACTCAGGTCGAACTGGCCGCCAACCAAATCAAGCTCGCG
GTGTTGGTAGCGACCAATTTCTTTGGCATCAACACCATTCCCATTGCGATCAATGAGGCC
GAGTACGTGGAGATGTGGGTTCGGGCCGCCACCACGATGGCGACCTATTCAACAGTCTCC
AGATCGGCGCTCTCCGCGATGCCGCACACCAGCCCCCCGCCGCTGATCCTGAAATCCGAT
GAACTGCTCCCCGACACCGGGGAGGACTCCGATGAAGACGGCCACAACCATGGCGGTCAC
AGTCATGGCGGTCACGCCAGGATGATCGATAACTTCTTTGCCGAAATCCTGCGTGGCGTC
AGCGCGGGCCGCATTGTTTGGGACCCCGTCAACGGCACCCTCAACGGACTCGACTACGAC
GATTACGTCTACCCCGGTCACGCGATCTGGTGGCTGGCTCGAGGCCTCGAGTTTTTTCAG
GATGGTGAACAATTTGGCGAACTGTTGTTCACCAATCCGACTGGGGCTTTTCAGTTCCTC
CTCTACGTCGTTGTGGTGGATTTGCCGACGCACATAGCCCAGATCGCTACCTGGCTGGGC
CAGTACCCGCAGTTGCTGTCGGCTGCCCTCACTGGCGTCATCGCCCACCTGGGAGCAATA
ACTGGTTTGGCGGGCCTATCCGGCCTGAGCGCCATTCCGTCTGCTGCGATACCCGCCGTT
GTACCGGAGCTGACACCCGTCGCGGCCGCGCCGCCTATGTTGGCGGTCGCCGGGGTGGGC
CCTGCAGTCGCCGCGCCGGGCATGCTCCCCGCCTCAGCACCCGCACCGGCGGCAGCGGCC
GGCGCCACCGCAGCCGGCCCGACGCCGCCGGCGACTGGTTTCGGAGGCTTCCCGCCCTAC
CTGGTCGGCGGTGGCGGCCCAGGAATAGGGTTCGGCTCGGGACAGTCGGCCCACGCCAAG
GCCGCGGCGTCCGATTCCGCTGCAGCCGAGTCGGCGGCCCAGGCCTCGGCGCGTGCGCAG
GCGCGTGCTGCACGGCGGGGCCGCTCGGCGGCGAAGGCACGTGGCCATCGTGACGAATTC
GTCACGATGGACATGGGTTTCGACGCGGCAGCTCCGGCCCCAGAGCACCAGCCGGGTGCC
CGGGCGTCCGACTGTGGTGCGGGACCTATCGGATTTGCTGGCACGGTGCGCAAAGAGGCG
GTCGTGAAAGCGGCGGGGTTGACCACGCTGGCCGGTGACGACTTCGGCGGCGGCCCAACG
ATGCCGATGATGCCCGGCACCTGGACCCATGATCAGGGCGTGTTCGACGAGCATCGCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv1386	active	styleankit01	2012-10-05
	authors,MJ. Brennan,G. Delogu The PE multigene family: a 'molecular mantra' for mycobacteria. Trends Microbiol. 2002
Interaction	Regulatory Rv1386	active	styleankit01	2012-10-05
	authors,NC. Gey van Pittius,SL. Sampson,H. Lee,Y. Kim,PD. van Helden,RM. Warren Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions. BMC Evol. Biol. 2006
Interaction	Regulatory Rv1386	active	styleankit01	2012-10-05
	authors,MJ. Brennan,G. Delogu The PE multigene family: a 'molecular mantra' for mycobacteria. Trends Microbiol. 2002
Interaction	Regulatory Rv1386	active	styleankit01	2012-10-05
	authors,NC. Gey van Pittius,SL. Sampson,H. Lee,Y. Kim,PD. van Helden,RM. Warren Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions. BMC Evol. Biol. 2006
Interaction	RegulatedBy Rv1221	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv2711	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. GM. Rodriguez, MI. Voskuil et al. ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infect. Immun. 2002