Rv1420 - excinuclease ABC subunit C uvrC

Expression: Most Significant Conditions for Rv1420

Protein Domains

Gene Information
Locus	Rv1420
Symbol	uvrC
Gene Name	excinuclease ABC subunit C uvrC
Location	1594042 - 1595982 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1941 bp Protein:647 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	685
Related Genes	Acel_1110 BL0703 CE1711 cg1795 DIP1314 jk1005 MAP1146 MAV_3360 Mkms_2442 ML0562 Mmcs_2395 MSMEG_3078 MT1463 MUL_1814 Mvan_2697 nfa35940 PPA0812 SAV6291
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1420
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1420 Transcript 1
MPDPATYRPAPGSIPVEPGVYRFRDQHGRVIYVGKAKSLRSRLTSYFADVASLAPRTRQL
VTTAAKVEWTVVGTEVEALQLEYTWIKEFDPRFNVRYRDDKSYPVLAVTLGEEFPRLMVY
RGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGVFKRHRQIDRPCLLGYIDKCS
APCIGRVDAAQHRQIVADFCDFLSGKTDRFARALEQQMNAAAEQLDFERAARLRDDLSAL
KRAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRVRGQRGWIVEKPGEPGDSGI
QLVEQFLTQFYGDQAALDDAADESANPVPREVLVPCLPSNAEELASWLSGLRGSRVVLRV
PRRGDKRALAETVHRNAEDALQQHKLKRASDFNARSAALQSIQDSLGLADAPLRIECVDV
SHVQGTDVVGSLVVFEDGLPRKSDYRHFGIREAAGQGRSDDVACIAEVTRRRFLRHLRDQ
SDPDLLSPERKSRRFAYPPNLYVVDGGAPQVNAASAVIDELGVTDVAVIGLAKRLEEVWV
PSEPDPIIMPRNSEGLYLLQRVRDEAHRFAITYHRSKRSTRMTASALDSVPGLGEHRRKA
LVTHFGSIARLKEATVDEITAVPGIGVATATAVHDALRPDSSGAAR*

Genomic Sequence

>Rv1420
GTGCCAGATCCCGCAACGTATCGCCCCGCGCCCGGGTCCATCCCGGTCGAGCCGGGCGTG
TACCGATTCCGGGACCAGCATGGGCGAGTCATCTACGTCGGCAAGGCCAAGAGCCTGCGT
AGCCGGCTGACGTCCTATTTTGCCGACGTGGCCAGCCTAGCGCCGCGGACCCGGCAGCTG
GTGACCACCGCGGCCAAGGTCGAATGGACGGTCGTGGGGACCGAGGTTGAGGCACTGCAG
CTGGAATACACCTGGATCAAGGAGTTCGATCCGCGATTCAACGTCCGCTACCGCGACGAC
AAGTCCTACCCTGTGCTGGCGGTCACCCTGGGCGAGGAATTTCCCCGGTTGATGGTCTAT
CGCGGTCCGCGGCGCAAGGGTGTGCGCTATTTCGGGCCGTACTCGCACGCGTGGGCAATC
CGGGAAACGCTGGATCTGCTCACCCGGGTGTTTCCGGCGCGAACTTGCTCGGCGGGGGTG
TTTAAGCGGCACAGGCAGATCGATCGTCCATGCCTGCTCGGCTACATCGACAAATGTTCC
GCGCCGTGTATTGGCAGGGTCGATGCGGCCCAGCACCGCCAGATCGTGGCAGACTTCTGC
GACTTTCTGTCCGGCAAGACCGACCGGTTCGCCCGCGCCTTGGAACAGCAAATGAACGCC
GCGGCCGAGCAACTGGACTTCGAACGAGCGGCGCGGCTTCGCGACGACCTGTCCGCACTG
AAGCGTGCCATGGAAAAGCAGGCCGTGGTGCTCGGGGACGGCACCGACGCCGACGTGGTG
GCATTCGCCGACGACGAACTCGAGGCGGCGGTGCAAGTGTTCCACGTGCGCGGCGGACGG
GTCCGCGGCCAGCGTGGCTGGATTGTCGAAAAGCCAGGAGAGCCAGGAGATTCCGGAATC
CAGTTGGTCGAGCAATTCCTGACACAGTTCTACGGCGACCAGGCGGCGTTGGACGACGCC
GCCGACGAATCCGCCAACCCGGTTCCCCGCGAGGTGCTGGTGCCCTGTTTGCCGTCCAAC
GCCGAGGAGCTGGCCAGCTGGCTGTCCGGCCTGCGCGGCTCAAGGGTCGTGCTGCGGGTG
CCGCGCCGCGGGGACAAGCGGGCACTGGCCGAAACGGTGCACCGAAACGCAGAAGATGCA
CTGCAACAACACAAGCTGAAGCGGGCCAGCGATTTCAACGCCAGATCCGCTGCGCTGCAG
AGCATTCAGGACTCGTTGGGCCTGGCAGACGCACCCTTGCGGATCGAGTGTGTCGACGTC
AGCCATGTGCAGGGCACCGACGTGGTCGGGTCACTGGTGGTGTTCGAAGACGGCCTGCCG
CGCAAGTCGGACTACCGCCACTTCGGGATCCGGGAAGCCGCAGGCCAGGGGCGCTCCGAC
GACGTGGCCTGTATTGCCGAGGTGACCCGGCGCCGCTTCCTGCGGCACCTGCGCGATCAG
AGCGATCCGGATCTTCTTTCTCCGGAAAGGAAGTCGCGTAGATTCGCCTATCCGCCCAAT
CTGTACGTCGTCGACGGCGGCGCGCCGCAAGTCAACGCGGCCAGTGCGGTAATCGACGAA
CTCGGTGTTACCGACGTCGCGGTGATCGGCCTGGCCAAGCGGCTGGAAGAGGTATGGGTG
CCGTCGGAGCCGGACCCGATTATCATGCCGCGCAACAGTGAGGGACTCTATCTGCTGCAG
CGAGTGCGAGACGAGGCACACCGGTTCGCTATCACCTACCATCGCAGCAAGCGGTCGACG
CGGATGACTGCCTCAGCGCTGGACTCGGTGCCGGGATTGGGGGAGCATCGCCGCAAAGCG
CTGGTCACCCATTTCGGATCGATCGCTCGCCTCAAGGAGGCCACCGTCGACGAAATCACC
GCTGTTCCCGGTATCGGCGTGGCCACGGCCACGGCCGTCCACGACGCACTGCGACCTGAC
TCATCGGGGGCCGCGCGATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Signaling Rv1354c	active	jgalag	2012-10-05
	Yeast two-hybrid (Physical interaction) T. Cui, L. Zhang et al. Uncovering new signaling proteins and potential drug targets through the interactome analysis of Mycobacterium tuberculosis. BMC Genomics 2009
Interaction	RegulatedBy Rv2720	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv2720	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Other	TBPWY:NER and related	active	vmizrahi	2012-03-05
	Small molecule inhibitor of UvrABC complex identified