Rv1447c - glucose-6-phosphate 1-dehydrogenase zwf2

Expression: Most Significant Conditions for Rv1447c

Protein Domains

Gene Information
Locus	Rv1447c
Symbol	zwf2
Gene Name	glucose-6-phosphate 1-dehydrogenase zwf2
Location	1625418 - 1626962 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1545 bp Protein:515 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	32926
Related Genes	Acel_1124 BL0440 CE1696 cg1778 DIP1304 jk0994 MAP1176c MAV_3329 Mkms_2458 Mmcs_2412 MSMEG_3101 MT1494 MUL_1842 Mvan_2718 nfa35750 PPA1563 SAV6313
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1447c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1447c Transcript 1
MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPP
TFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRLAEGFRFVPGTFDDDDAFAQ
LAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGDRWSRVVIEKPFGH
DLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQI
TMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSAT
RLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPF
YLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPG
TAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEH
WAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP*

Genomic Sequence

>Rv1447c
ATGAAACCGGCCCACGCCGCGGCGTCGTGGCGCAACCCGCTACGAGACAAGCGGGACAAG
CGATTACCCAGAATCGCCGGCCCGTGCGGCATGGTGATTTTCGGCGTCACCGGCGACCTG
GCCCGCAAGAAGGTGATGCCGGCCGTCTACGATTTGGCCAACCGCGGCCTGCTGCCGCCC
ACATTCTCGCTGGTGGGGTTTGCCCGCCGAGACTGGAGCACCCAGGATTTCGGTCAAGTG
GTGTACAACGCCGTCCAAGAGCACTGCCGAACACCGTTTCGGCAACAGAACTGGGACCGG
CTGGCCGAGGGATTCCGTTTTGTGCCAGGCACTTTCGACGACGACGACGCGTTCGCCCAA
CTCGCCGAGACGCTGGAGAAGCTCGACGCCGAGCGCGGCACCGGCGGCAACCACGCCTTC
TACCTGGCGATCCCGCCCAAATCCTTCCCGGTGGTGTGTGAGCAGCTGCACAAGTCCGGC
CTGGCCCGCCCGCAAGGCGACCGGTGGAGCCGAGTCGTGATAGAGAAGCCGTTCGGCCAC
GACCTGGCCAGCGCACGCGAGCTGAACAAGGCGGTCAACGCGGTCTTCCCGGAGGAAGCG
GTCTTCCGCATCGACCACTACCTGGGCAAAGAGACGGTGCAGAACATCCTGGCGCTGCGG
TTCGCCAACCAGCTGTTCGACCCGATCTGGAATGCGCACTACGTCGACCACGTACAGATC
ACCATGGCCGAAGACATCGGCCTGGGCGGGCGCGCGGGCTATTACGACGGCATCGGCGCG
GCCCGCGATGTCATCCAGAACCATCTCATGCAGCTGCTGGCGCTGACCGCGATGGAGGAG
CCGGTCAGCTTCCACCCGGCAGCGTTGCAGGCCGAGAAGATCAAGGTGCTCTCGGCCACC
CGCCTTGCCGAGCCACTCGACCAGACCACCAGCCGCGGCCAGTACGCCGCCGGCTGGCAA
GGCGGGGAGAAGGTGGTTGGGCTGCTCGACGAGGAGGGGTTCGCCGAGGACTCCACCACC
GAAACCTTCGCCGCTATCACCCTGGAAGTCGATACGCGCCGGTGGGCCGGCGTGCCGTTC
TATCTGCGAACGGGAAAACGATTGGGCCGCCGGGTGACCGAGATCGCTCTGGTCTTCAGG
CGGGCGCCGCATCTGCCGTTCGACGCCACCATGACCGACGAGCTGGGCACCAACGCGATG
GTCATCCGCGTGCAGCCCGACGAAGGTGTCACATTGCGGTTCGGCTCCAAGGTGCCGGGC
ACCGCCATGGAAGTCCGCGACGTCAACATGGACTTCTCCTACGGCTCGGCATTCGCCGAA
GATTCACCGGAGGCCTACGAGCGGCTCATCCTCGACGTCCTGCTCGGCGAGCCCTCGCTG
TTTCCGGTCAACGCGGAGGTCGAACTGGCGTGGGAGATCCTCGATCCAGCGTTGGAACAT
TGGGCGGCACACGGGACGCCCGACGCCTACGAGGCAGGTACCTGGGGTCCGGAATCATCC
TTGGAGATGCTGCGCCGCACCGGCCGGGAATGGCGGCGGCCATAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Activation Rv1446c	active	shahanup86	2012-10-05
	Co-occurrence (Functional linkage) authors,KD. Hagen,JC. Meeks The unique cyanobacterial protein OpcA is an allosteric effector of glucose-6-phosphate dehydrogenase in Nostoc punctiforme ATCC 29133. J. Biol. Chem. 2001
Interaction	Activation Rv1446c	active	shahanup86	2012-10-05
	Co-occurrence (Functional linkage) authors,S. Sundaram,H. Karakaya,DJ. Scanlan,NH. Mann Multiple oligomeric forms of glucose-6-phosphate dehydrogenase in cyanobacteria and the role of OpcA in the assembly process. Microbiology (Reading, Engl.) 1998
Interaction	RegulatedBy Rv1931c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv1931c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Term	EC:1.1.1.49 Glucose-6-phosphate 1-dehydrogenase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011