Rv1484 - NADH-dependent enoyl-[acyl-carrier-protein] reductase inhA
Protein Domains

Gene Information
LocusRv1484
SymbolinhA
Gene NameNADH-dependent enoyl-[acyl-carrier-protein] reductase inhA
Location1674202 - 1675011 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:810 bp
Protein:270 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number28455
Related GenesAcel_1152 MAP1210 MAV_3294 Mkms_2502 ML1806 Mmcs_2457 MSMEG_3151 MT1531 MUL_1492 Mvan_2753 nfa34760 PPA1532 SAV2295 SAV6463
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
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Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
TermTBRXN:FAS140 fatty acid synthase (n-C14:0) - IDAactivenjamshidi2012-10-05
mtFABH (Rv0533c) - link between FAS I and FAS II - highest affinity for C12:0, see PMID: 10840036 (since FA synthesis is lumped, does not extend immediately to FAS II).
KH. Choi, L. Kremer et al. Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. J. Biol. Chem. 2000
TermEC:2.3.1.85 Fatty-acid synthase. - IDAactivenjamshidi2012-10-05
mtFABH (Rv0533c) - link between FAS I and FAS II - highest affinity for C12:0, see PMID: 10840036 (since FA synthesis is lumped, does not extend immediately to FAS II).
KH. Choi, L. Kremer et al. Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. J. Biol. Chem. 2000
InteractionInhibition Rv0197activeaparna.vchalam2012-10-05
Affinity purification (Physical interaction)
ME. Boyne, TJ. Sullivan et al. Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors. Antimicrob. Agents Chemother. 2007
InteractionInhibition Rv0197activeaparna.vchalam2012-10-05
Affinity purification (Physical interaction)
authors,L. Cabusora,E. Sutton,A. Fulmer,CV. Forst Differential network expression during drug and stress response. Bioinformatics 2005
Name2-trans-Enoyl-ACP reductaseactivemjackson2012-10-05
FAS-II
TermEC:1.3.1.9 Enoyl-[acyl-carrier-protein] reductase (NADH). - NRactiveextern:JZUCKER2012-03-06
Reaction blocked in mutant
A. Quémard, JC. Sacchettini et al. Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis. Biochemistry 1995
TermEC:1.3.1.10 Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific). - NRactiveextern:JZUCKER2012-03-06
Reaction blocked in mutant
A. Quémard, JC. Sacchettini et al. Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis. Biochemistry 1995
TermEC:2.3.1.41 Beta-ketoacyl-acyl-carrier-protein synthase I. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005
TermEC:2.1.1.- Transferases. Transferring one-carbon groups. Methyltransferases. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005