Rv1787 - PPE family protein

Expression: Most Significant Conditions for Rv1787

Protein Domains

Gene Information
Locus	Rv1787
Symbol	PPE25
Gene Name	PPE family protein
Location	2025301 - 2026398 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1098 bp Protein:366 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	13741
Related Genes	MT1836 MUL_3089
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1787
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1787 Transcript 1
MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLAATGYASVIAELTGAPWVGA
ASLSMVAAATPYVAWLSQAAARAEQAGMQAAAAAAAYEAAFVMTVPPPVITANRVLVMTL
IATNFFGQNSAAIAVAEAQYAEMWAQDAVAMYGYAAASASASRLIPFAAPPKTTNSAGVV
AQVAAVAAMPGLLQRLSSAASVSWSNPNDWWLVRLLGSITPTERTTIVRLLGQSYFATGM
AQFFASIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGASRAVSASLARANKIGALSVPPSW
VKTTALTESPVAHAVSANPTVGSSHGPHGLLRGLPLGSRITRRSGAFAHRYGFRHSVVAR
PPSAG*

Genomic Sequence

>Rv1787
TTGGACTTCGGGGCGTTACCGCCGGAGATCAATTCGGGCCGTATGTATTGCGGTCCGGGG
TCGGGGCCGATGCTGGCTGCGGCCGCGGCCTGGGACGGGGTGGCCGTGGAGTTGGGGTTG
GCTGCGACCGGTTATGCGTCGGTGATAGCCGAGCTGACCGGTGCGCCGTGGGTGGGTGCG
GCGTCGTTGTCGATGGTGGCGGCGGCCACGCCGTATGTGGCCTGGCTGAGCCAAGCCGCG
GCGCGGGCCGAGCAGGCGGGGATGCAGGCCGCGGCGGCCGCGGCGGCTTATGAGGCCGCT
TTTGTGATGACGGTGCCGCCGCCGGTGATTACGGCGAATCGGGTTTTGGTGATGACGCTG
ATTGCGACCAATTTTTTCGGTCAGAACTCGGCGGCGATCGCGGTCGCTGAGGCGCAGTAC
GCCGAAATGTGGGCGCAAGACGCCGTTGCTATGTATGGCTATGCGGCTGCGTCGGCGAGC
GCGTCGCGGTTGATTCCGTTCGCGGCGCCGCCGAAGACCACCAACTCCGCTGGGGTGGTC
GCACAGGTGGCTGCGGTCGCGGCGATGCCTGGACTGCTGCAACGACTTTCGTCGGCTGCA
TCGGTCAGCTGGTCGAATCCCAATGATTGGTGGCTCGTGCGGTTGCTGGGCTCGATTACC
CCCACGGAAAGGACGACGATCGTTCGTTTGCTCGGTCAGTCGTACTTCGCGACGGGCATG
GCGCAGTTCTTCGCCTCGATCGCACAGCAGCTGACCTTCGGCCCAGGGGGCACAACGGCT
GGCTCCGGCGGAGCCTGGTACCCAACGCCGCAATTCGCCGGCCTGGGTGCAAGCCGGGCG
GTGTCGGCGAGTTTGGCGCGGGCCAACAAGATTGGGGCTCTGTCGGTTCCGCCGAGCTGG
GTCAAAACGACTGCACTGACCGAAAGCCCGGTCGCCCACGCGGTGAGCGCCAACCCTACC
GTCGGTTCGTCACACGGACCGCATGGCCTGCTCCGCGGACTGCCGCTAGGGTCGCGGATC
ACTCGGCGTAGCGGCGCCTTTGCCCACCGATATGGGTTCCGTCACAGTGTGGTTGCCCGC
CCGCCATCGGCCGGATAA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv1788	active	akankshajain.21	2012-10-05
	S. Tundup, Y. Akhter et al. Clusters of PE and PPE genes of Mycobacterium tuberculosis are organized in operons: evidence that PE Rv2431c is co-transcribed with PPE Rv2430c and their gene products interact with each other. FEBS Lett. 2006
Interaction	PhysicalInteraction Rv1788	active	akankshajain.21	2012-10-05
	authors,SS. Jha,L. Danelishvili,D. Wagner,J. Maser,YJ. Li,I. Moric,S. Vogt,Y. Yamazaki,B. Lai,LE. Bermudez Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages. BMC Microbiol. 2010
Interaction	PhysicalInteraction Rv1788	active	akankshajain.21	2012-10-05
	S. Tundup, Y. Akhter et al. Clusters of PE and PPE genes of Mycobacterium tuberculosis are organized in operons: evidence that PE Rv2431c is co-transcribed with PPE Rv2430c and their gene products interact with each other. FEBS Lett. 2006
Symbol	PPE25-PE19	active	jlew	2012-03-07
	Mutant is defective in ESXN and PPE41 secretion. Mutant is attenuated in macrophages and SCID mice. authors,D. Bottai,M. Di Luca,L. Majlessi,W. Frigui,R. Simeone,F. Sayes,W. Bitter,MJ. Brennan,C. Leclerc,G. Batoni,M. Campa,R. Brosch,S. Esin Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation. Molecular microbiology 2012