Rv1821 - preprotein translocase ATPase secA2

Expression: Most Significant Conditions for Rv1821

Protein Domains

Gene Information
Locus	Rv1821
Symbol	secA2
Gene Name	preprotein translocase ATPase secA2
Location	2066457 - 2068883 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:2427 bp Protein:809 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	33458
Related Genes	CE1572 cg1629 DIP1203 jk0902 MAP1534 MAV_2894 Mkms_2894 ML2082 Mmcs_2850 MSMEG_3654 MT1869 MUL_3040 Mvan_3162 SAV2565
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1821
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1821 Transcript 1
MNVHGCPRIAACRCTDTHPRGRPAFAYRWFVPKTTRAQPGRLSSRFWRLLGASTEKNRSR
SLADVTASAEYDKEAADLSDEKLRKAAGLLNLDDLAESADIPQFLAIAREAAERRTGLRP
FDVQLLGALRMLAGDVIEMATGEGKTLAGAIAAAGYALAGRHVHVVTINDYLARRDAEWM
GPLLDAMGLTVGWITADSTPDERRTAYDRDVTYASVNEIGFDVLRDQLVTDVNDLVSPNP
DVALIDEADSVLVDEALVPLVLAGTTHRETPRLEIIRLVAELVGDKDADEYFATDSDNRN
VHLTEHGARKVEKALGGIDLYSEEHVGTTLTEVNVALHAHVLLQRDVHYIVRDDAVHLIN
ASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEVLDTITVQALINRYATVCGMTGTALAA
GEQLRQFYQLGVSPIPPNKPNIREDEADRVYITTAAKNDGIVEHITEVHQRGQPVLVGTR
DVAESEELHERLVRRGVPAVVLNAKNDAEEARVIAEAGKYGAVTVSTQMAGRGTDIRLGG
SDEADHDRVAELGGLHVVGTGRHHTERLDNQLRGRAGRQGDPGSSVFFSSWEDDVVAANL
DHNKLPMATDENGRIVSPRTGSLLDHAQRVAEGRLLDVHANTWRYNQLIAQQRAIIVERR
NTLLRTVTAREELAELAPKRYEELSDKVSEERLETICRQIMLYHLDRGWADHLAYLADIR
ESIHLRALGRQNPLDEFHRMAVDAFASLAADAIEAAQQTFETANVLDHEPGLDLSKLARP
TSTWTYMVNDNPLSDDTLSALSLPGVFR*

Genomic Sequence

>Rv1821
GTGAACGTGCACGGTTGTCCACGAATTGCGGCCTGTCGGTGTACAGACACGCACCCTCGC
GGCCGGCCGGCATTCGCGTACCGTTGGTTTGTGCCCAAGACCACCCGCGCTCAACCCGGC
CGGCTGAGCAGCCGATTCTGGCGATTGCTCGGCGCCAGCACCGAAAAGAACCGGAGCCGC
TCCCTGGCGGATGTAACCGCTTCGGCAGAATACGACAAGGAAGCTGCCGATCTGTCCGAC
GAGAAGCTGCGTAAGGCGGCAGGCCTGCTCAACCTCGACGACCTCGCGGAGTCCGCCGAT
ATCCCGCAGTTTCTCGCGATTGCCCGGGAAGCCGCCGAGCGGAGGACCGGGCTGCGACCA
TTTGATGTGCAGTTGCTTGGCGCGTTGCGCATGCTCGCCGGAGACGTGATCGAGATGGCC
ACCGGTGAGGGCAAAACCCTTGCCGGGGCGATCGCGGCCGCCGGTTATGCGCTGGCCGGC
CGGCACGTGCACGTCGTGACGATTAACGATTACCTGGCCCGCCGCGATGCGGAGTGGATG
GGCCCGCTGCTGGACGCGATGGGCCTGACGGTCGGCTGGATCACCGCGGACTCGACCCCT
GACGAGCGCCGGACCGCATATGACCGTGATGTCACCTATGCCTCGGTCAACGAGATTGGC
TTCGATGTACTGCGCGATCAGTTGGTGACTGATGTCAATGACCTGGTATCGCCCAATCCA
GACGTGGCTCTCATCGACGAAGCCGACTCCGTGCTGGTCGACGAGGCGCTGGTGCCCCTG
GTGCTGGCCGGAACCACACATCGTGAGACGCCGCGGCTGGAGATCATCCGGCTGGTCGCT
GAGCTTGTTGGCGACAAGGACGCCGACGAGTACTTTGCCACCGATTCCGATAACCGCAAT
GTCCACTTGACCGAGCACGGGGCACGCAAAGTCGAGAAAGCGCTCGGTGGCATCGACCTG
TACTCCGAGGAGCACGTCGGCACCACACTGACTGAGGTCAATGTCGCGCTGCACGCGCAT
GTGCTCCTGCAACGCGACGTGCACTACATCGTCCGCGACGACGCGGTGCACCTGATCAAC
GCGTCGCGTGGCCGTATCGCGCAACTGCAGCGCTGGCCGGACGGGTTGCAAGCTGCGGTC
GAGGCCAAGGAAGGTATCGAGACCACGGAAACTGGGGAAGTGCTCGACACCATCACGGTG
CAGGCCCTGATCAACCGGTATGCGACTGTGTGCGGAATGACGGGAACCGCGCTGGCCGCC
GGTGAGCAGCTACGGCAGTTCTACCAGCTCGGTGTCTCACCGATACCACCGAACAAGCCA
AACATCCGCGAGGACGAGGCCGACCGGGTCTACATCACCACTGCAGCCAAGAACGACGGG
ATCGTCGAGCACATCACCGAGGTGCACCAGAGGGGGCAGCCTGTGCTGGTCGGTACCCGC
GACGTGGCCGAATCCGAGGAACTGCACGAACGCCTGGTGCGCCGCGGTGTGCCCGCCGTG
GTGCTCAACGCGAAGAACGACGCCGAGGAGGCCCGGGTCATCGCCGAGGCCGGCAAATAC
GGCGCGGTCACGGTGTCAACTCAAATGGCCGGGCGCGGCACCGACATCAGGCTCGGCGGG
TCCGACGAAGCTGACCACGACAGGGTCGCGGAATTGGGCGGCCTGCACGTGGTCGGCACT
GGCCGTCACCACACCGAGCGGCTAGACAACCAGCTGCGCGGTCGGGCCGGGCGCCAGGGA
GATCCCGGGTCGTCGGTGTTTTTCTCAAGCTGGGAAGACGATGTCGTTGCGGCCAACCTC
GACCACAACAAGCTGCCGATGGCAACCGACGAAAATGGCCGGATTGTCAGCCCGAGGACG
GGTAGTCTGCTCGACCATGCCCAGCGCGTTGCCGAGGGCCGGTTATTGGATGTGCACGCC
AACACGTGGCGCTACAACCAGCTGATCGCCCAGCAGCGCGCCATCATCGTCGAACGGCGT
AACACGTTGTTGCGCACCGTAACCGCGCGTGAGGAACTCGCCGAACTGGCGCCTAAGCGG
TACGAGGAGCTGTCCGACAAAGTATCCGAGGAACGCCTCGAGACGATTTGTCGGCAGATC
ATGCTGTATCACCTCGACCGTGGCTGGGCCGATCACCTGGCGTATCTGGCCGACATCCGG
GAGAGCATCCATCTACGCGCGCTGGGCCGGCAGAACCCACTCGACGAGTTTCACCGGATG
GCTGTGGACGCGTTCGCGTCGCTGGCCGCCGACGCCATCGAGGCGGCTCAACAGACGTTC
GAAACCGCGAACGTCCTTGACCACGAGCCGGGGCTGGACCTGTCCAAACTGGCCCGGCCG
ACGTCGACATGGACCTACATGGTCAATGACAACCCACTGTCCGATGACACGCTTTCTGCC
CTCAGTCTGCCCGGGGTGTTCCGCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv3240c	active	bhupender.srcp	2012-10-05
	Affinity purification(Physical Interaction) JM. Hou, NG. D'Lima et al. ATPase activity of Mycobacterium tuberculosis SecA1 and SecA2 proteins and its importance for SecA2 function in macrophages. J. Bacteriol. 2008
Interaction	PhysicalInteraction Rv3240c	active	bhupender.srcp	2012-10-05
	Affinity purification(Physical Interaction) M. Braunstein, AM. Brown et al. Two nonredundant SecA homologues function in mycobacteria. J. Bacteriol. 2001
Interaction	PhysicalInteraction Rv3240c	active	atulkatarkar	2012-10-05
	Strucural analysis M. Braunstein, BJ. Espinosa et al. SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis. Mol. Microbiol. 2003
Interaction	PhysicalInteraction Rv3240c	active	atulkatarkar	2012-10-05
	Strucural analysis M. Braunstein, AM. Brown et al. Two nonredundant SecA homologues function in mycobacteria. J. Bacteriol. 2001
Interaction	PhysicalInteraction Rv0732	active	anshula.arora1990	2012-10-05
	Structural analysis JM. Hou, NG. D'Lima et al. ATPase activity of Mycobacterium tuberculosis SecA1 and SecA2 proteins and its importance for SecA2 function in macrophages. J. Bacteriol. 2008
Interaction	PhysicalInteraction Rv0732	active	anshula.arora1990	2012-10-05
	Structural analysis authors,C. Tziatzios,D. Schubert,M. Lotz,D. Gundogan,H. Betz,H. Schägger,W. Haase,F. Duong,I. Collinson The bacterial protein-translocation complex: SecYEG dimers associate with one or two SecA molecules. J. Mol. Biol. 2004