Rv2051c - polyprenol-monophosphomannose synthase ppm1

Expression: Most Significant Conditions for Rv2051c

Protein Domains

Gene Information
Locus	Rv2051c
Symbol	ppm1
Gene Name	polyprenol-monophosphomannose synthase ppm1
Location	2308131 - 2310755 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:2625 bp Protein:875 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	36524
Related Genes	Acel_1210 Acel_1211 CE1606 CE1607 cg1672 cg1673 DIP1226 DIP1227 jk0935 jk0936 MAP1799c MAP1800c Mkms_2547 Mkms_2548 ML1440 ML1441 Mmcs_2502 Mmcs_2503 MSMEG_3859 MSMEG_3860 MT2111 MUL_2269 MUL_5127 Mvan_3418 Mvan_3419 nfa31180 nfa6160 PPA1221 PPA1222 SAV1422 SAV6923
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2051c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2051c Transcript 1
MKLGAWVAAQLPTTRTAVRTRLTRLVVSIVAGLLLYASFPPRNCWWAAVVALALLAWVLT
HRATTPVGGLGYGLLFGLVFYVSLLPWIGELVGPGPWLALATTCALFPGIFGLFAVVVRL
LPGWPIWFAVGWAAQEWLKSILPFGGFPWGSVAFGQAEGPLLPLVQLGGVALLSTGVALV
GCGLTAIALEIEKWWRTGGQGDAPPAVVLPAACICLVLFAAIVVWPQVRHAGSGSGGEPT
VTVAVVQGNVPRLGLDFNAQRRAVLDNHVEETLRLAADVHAGLAQQPQFVIWPENSSDID
PFVNPDAGQRISAAAEAIGAPILIGTLMDVPGRPRENPEWTNTAIVWNPGTGPADRHDKA
IVQPFGEYLPMPWLFRHLSGYADRAGHFVPGNGTGVVRIAGVPVGVATCWEVIFDRAPRK
SILGGAQLLTVPSNNATFNKTMSEQQLAFAKVRAVEHDRYVVVAGTTGISAVIAPDGGEL
IRTDFFQPAYLDSQVRLKTRLTPATRWGPILQWILVGAAAAVVLVAMRQNGWFPRPRRSE
PKGENDDSDAPPGRSEASGPPALSESDDELIQPEQGGRHSSGFGRHRATSRSYMTTGQPA
PPAPGNRPSQRVLVIIPTFNERENLPVIHRRLTQACPAVHVLVVDDSSPDGTGQLADELA
QADPGRTHVMHRTAKNGLGAAYLAGFAWGLSREYSVLVEMDADGSHAPEQLQRLLDAVDA
GADLAIGSRYVAGGTVRNWPWRRLVLSKTANTYSRLALGIGIHDITAGYRAYRREALEAI
DLDGVDSKGYCFQIDLTWRTVSNGFVVTEVPITFTERELGVSKMSGSNIREALVKVARWG
IEGRLSRSDHARARPDIARPGAGGSRVSRADVTE*

Genomic Sequence

>Rv2051c
GTGAAGCTTGGCGCCTGGGTGGCAGCGCAGCTGCCCACCACACGGACCGCGGTGCGGACG
CGGCTGACGCGCCTGGTGGTCAGCATCGTGGCCGGTCTGCTGTTGTATGCCAGCTTCCCG
CCGCGCAACTGCTGGTGGGCGGCGGTGGTTGCGCTCGCATTGCTGGCCTGGGTGCTGACC
CACCGCGCGACGACACCGGTGGGTGGGCTGGGCTACGGCCTGCTATTCGGCCTGGTGTTC
TACGTCTCGTTGTTGCCGTGGATCGGCGAGCTGGTGGGCCCCGGGCCCTGGTTGGCACTG
GCGACGACGTGCGCGCTGTTCCCCGGCATCTTCGGTCTGTTCGCCGTCGTGGTACGCCTG
TTGCCGGGTTGGCCGATCTGGTTCGCGGTGGGGTGGGCGGCGCAGGAGTGGTTGAAGTCG
ATCCTTCCGTTCGGTGGATTTCCGTGGGGGTCGGTCGCCTTCGGTCAAGCCGAAGGCCCG
CTGTTGCCGTTGGTCCAGCTCGGCGGTGTGGCGCTGCTGTCAACGGGGGTAGCGCTGGTC
GGATGCGGCTTGACCGCGATCGCGCTGGAAATCGAGAAGTGGTGGCGAACCGGTGGTCAG
GGGGATGCGCCGCCGGCGGTGGTGCTGCCGGCCGCGTGCATATGCCTGGTCTTGTTCGCC
GCCATCGTCGTCTGGCCGCAGGTGCGGCATGCGGGTAGCGGATCGGGCGGCGAACCCACG
GTCACCGTCGCGGTGGTCCAGGGCAATGTGCCCCGGCTCGGTCTCGACTTCAATGCGCAA
CGTCGGGCGGTGCTAGACAACCACGTTGAGGAGACGTTGCGGCTGGCCGCCGACGTGCAT
GCGGGGCTGGCGCAGCAACCCCAGTTCGTCATCTGGCCGGAGAACTCGTCGGACATCGAC
CCGTTCGTCAACCCCGACGCCGGTCAACGGATCTCCGCAGCGGCCGAAGCGATCGGCGCG
CCGATCCTGATCGGCACCCTGATGGATGTTCCGGGCCGTCCTCGTGAAAATCCGGAGTGG
ACCAATACGGCCATTGTCTGGAATCCCGGCACCGGGCCGGCCGACCGCCACGACAAGGCA
ATCGTGCAGCCCTTCGGCGAGTACCTGCCCATGCCGTGGCTGTTTCGGCACCTCTCCGGC
TACGCCGACCGCGCCGGCCACTTCGTGCCCGGCAACGGCACCGGTGTGGTGCGCATCGCT
GGGGTCCCGGTCGGGGTGGCTACCTGCTGGGAGGTGATCTTCGACCGCGCCCCGCGGAAG
TCGATTCTGGGCGGCGCGCAGCTGTTGACCGTGCCCAGCAACAACGCCACCTTCAACAAG
ACAATGAGCGAACAGCAGCTGGCATTCGCCAAGGTACGGGCCGTCGAGCACGACAGATAC
GTGGTGGTTGCCGGTACCACTGGGATCAGTGCGGTGATAGCACCAGACGGGGGTGAGCTG
ATCCGGACCGACTTTTTCCAGCCCGCATACCTGGACAGCCAGGTGCGCCTCAAGACGAGG
CTGACACCGGCAACTCGATGGGGTCCAATCCTGCAATGGATTCTCGTCGGGGCAGCCGCA
GCGGTCGTTCTCGTCGCCATGCGGCAGAATGGGTGGTTCCCGCGTCCGAGGCGCTCGGAG
CCAAAGGGCGAAAATGACGATTCCGATGCGCCCCCGGGCAGATCTGAGGCCTCCGGTCCG
CCGGCCCTGAGTGAATCCGACGACGAACTCATTCAGCCCGAGCAGGGCGGCCGACACTCA
TCCGGTTTCGGACGACACAGAGCAACATCGAGGAGTTACATGACCACCGGCCAGCCGGCG
CCCCCAGCCCCGGGTAACCGTCCCAGCCAGCGCGTCCTGGTGATCATTCCTACGTTCAAC
GAGCGGGAGAACCTTCCGGTGATCCACCGGCGGCTGACGCAAGCATGCCCCGCCGTGCAC
GTGCTGGTCGTCGACGACAGCAGCCCCGACGGCACCGGCCAGCTCGCCGACGAGCTGGCG
CAGGCCGATCCCGGCCGCACCCACGTGATGCACCGCACCGCCAAGAACGGTTTGGGCGCG
GCGTACCTGGCAGGTTTCGCCTGGGGGTTGAGCCGGGAGTATTCGGTGCTGGTCGAGATG
GATGCCGACGGCAGCCACGCGCCCGAACAGCTGCAGCGCCTGCTGGACGCCGTCGACGCT
GGTGCCGATCTTGCGATTGGTTCGCGCTATGTCGCGGGGGGGACGGTACGAAACTGGCCT
TGGCGGCGGCTAGTCCTGTCCAAAACCGCTAACACCTATTCGCGCCTGGCGCTCGGAATC
GGGATCCACGACATCACCGCTGGCTACCGCGCGTACCGCCGCGAAGCACTCGAAGCGATT
GACCTGGACGGCGTGGACTCCAAGGGCTACTGCTTCCAGATCGATCTCACCTGGCGCACG
GTGAGCAACGGGTTCGTCGTCACCGAGGTGCCGATTACCTTTACCGAGCGCGAGCTCGGT
GTGTCCAAGATGAGCGGGTCCAACATTCGTGAGGCGCTGGTCAAAGTCGCCCGCTGGGGC
ATCGAGGGACGCCTTTCGCGCTCGGACCACGCACGCGCACGACCGGACATTGCCCGGCCG
GGAGCAGGGGGTTCCCGGGTCAGCCGCGCCGACGTGACCGAATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:GMT2 gdp mannosyl phosphate transferase - IPI	active	njamshidi	2012-10-05
	known to occur physiologically (see Tuberculist for example - also demonstrated biochemically see PMID: 11931640, 15228522) - specific biochemical mechanism has not been elucidated. authors,V. Briken,SA. Porcelli,GS. Besra,L. Kremer Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response. Mol. Microbiol. 2004
Term	TBRXN:GMT2 gdp mannosyl phosphate transferase - IPI	active	njamshidi	2012-10-05
	known to occur physiologically (see Tuberculist for example - also demonstrated biochemically see PMID: 11931640, 15228522) - specific biochemical mechanism has not been elucidated. SS. Gurcha, AR. Baulard et al. Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis. Biochem. J. 2002
Term	TBRXN:GMT2 gdp mannosyl phosphate transferase - ISS	active	njamshidi	2012-10-05
	known to occur physiologically (see Tuberculist for example - also demonstrated biochemically see PMID: 11931640, 15228522) - specific biochemical mechanism has not been elucidated. authors,V. Briken,SA. Porcelli,GS. Besra,L. Kremer Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response. Mol. Microbiol. 2004
Term	TBRXN:GMT2 gdp mannosyl phosphate transferase - ISS	active	njamshidi	2012-10-05
	known to occur physiologically (see Tuberculist for example - also demonstrated biochemically see PMID: 11931640, 15228522) - specific biochemical mechanism has not been elucidated. SS. Gurcha, AR. Baulard et al. Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis. Biochem. J. 2002
Term	TBRXN:GMT1 gdp mannosyl phosphate transferase - IPI	active	njamshidi	2012-10-05
	known to occur physiologically (see Tuberculist for example - also demonstrated biochemically see PMID: 11931640, 15228522) - specific biochemical mechanism has not been elucidated. authors,V. Briken,SA. Porcelli,GS. Besra,L. Kremer Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response. Mol. Microbiol. 2004
Term	TBRXN:GMT1 gdp mannosyl phosphate transferase - IPI	active	njamshidi	2012-10-05
	known to occur physiologically (see Tuberculist for example - also demonstrated biochemically see PMID: 11931640, 15228522) - specific biochemical mechanism has not been elucidated. SS. Gurcha, AR. Baulard et al. Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis. Biochem. J. 2002
Term	TBRXN:GMT1 gdp mannosyl phosphate transferase - ISS	active	njamshidi	2012-10-05
	known to occur physiologically (see Tuberculist for example - also demonstrated biochemically see PMID: 11931640, 15228522) - specific biochemical mechanism has not been elucidated. authors,V. Briken,SA. Porcelli,GS. Besra,L. Kremer Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response. Mol. Microbiol. 2004
Term	TBRXN:GMT1 gdp mannosyl phosphate transferase - ISS	active	njamshidi	2012-10-05
	known to occur physiologically (see Tuberculist for example - also demonstrated biochemically see PMID: 11931640, 15228522) - specific biochemical mechanism has not been elucidated. SS. Gurcha, AR. Baulard et al. Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis. Biochem. J. 2002