Rv2068c - class A beta-lactamase blaC

Expression: Most Significant Conditions for Rv2068c

Protein Domains

Gene Information
Locus	Rv2068c
Symbol	blaC
Gene Name	class A beta-lactamase blaC
Location	2325886 - 2326809 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:924 bp Protein:308 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	2497
Related Genes	Mkms_2148 Mmcs_2102 MSMEG_2658 MT2128 MUL_2294 Mvan_2352 nfa23080 SAV4452
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2068c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2068c Transcript 1
MRNRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADLADRFAELERRYDARLG
VYVPATGTTAAIEYRADERFAFCSTFKAPLVAAVLHQNPLTHLDKLITYTSDDIRSISPV
AQQHVQTGMTIGQLCDAAIRYSDGTAANLLLADLGGPGGGTAAFTGYLRSLGDTVSRLDA
EEPELNRDPPGDERDTTTPHAIALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAG
FPADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRAGGGYDAEPREALLAEAAT
CVAGVLA*

Genomic Sequence

>Rv2068c
ATGCGCAACAGAGGATTCGGTCGTCGCGAACTGCTGGTAGCGATGGCAATGCTGGTTTCC
GTGACGGGGTGTGCACGGCATGCGAGCGGGGCCCGTCCGGCATCGACAACCTTGCCGGCC
GGAGCGGATCTGGCGGATCGCTTCGCCGAGCTGGAGCGCAGATACGATGCCCGGCTTGGG
GTGTATGTGCCCGCCACCGGCACCACCGCCGCGATCGAATACCGCGCCGATGAGCGGTTC
GCATTCTGCTCCACGTTCAAGGCGCCGCTCGTGGCGGCGGTGCTGCACCAAAACCCGCTC
ACGCATCTGGACAAACTGATCACCTACACCAGTGACGACATTCGGTCGATCTCCCCGGTG
GCCCAACAACACGTTCAGACCGGGATGACGATCGGGCAGCTTTGCGATGCGGCGATACGC
TATAGCGACGGCACCGCCGCCAACCTGTTGCTGGCCGATCTTGGCGGTCCCGGGGGCGGC
ACCGCGGCATTTACCGGCTACCTCCGCAGCTTGGGTGACACCGTGAGCCGGTTGGACGCC
GAGGAACCGGAGTTGAACCGCGATCCGCCCGGGGACGAACGGGATACCACAACACCGCAC
GCCATCGCCCTGGTGTTGCAGCAGCTTGTTCTCGGCAACGCGTTGCCGCCCGACAAGCGG
GCACTGCTCACCGATTGGATGGCGCGCAACACCACCGGAGCCAAGCGGATCCGAGCGGGC
TTTCCCGCCGATTGGAAGGTGATCGACAAGACCGGGACCGGTGACTACGGACGAGCAAAC
GACATCGCGGTCGTGTGGTCACCGACCGGCGTGCCCTACGTGGTGGCCGTCATGTCCGAT
CGTGCCGGCGGCGGGTATGACGCCGAGCCCCGTGAGGCGCTGCTCGCCGAGGCGGCGACG
TGCGTTGCCGGTGTGCTTGCATAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv2094c	active	ashwinigbhat	2012-10-05
	Spectrophotometric Analysis JA. McDonough, KE. Hacker et al. The twin-arginine translocation pathway of Mycobacterium smegmatis is functional and required for the export of mycobacterial beta-lactamases. J. Bacteriol. 2005
Interaction	PhysicalInteraction Rv2094c	active	ashwinigbhat	2012-10-05
	Spectrophotometric Analysis JE. Posey, TM. Shinnick et al. Characterization of the twin-arginine translocase secretion system of Mycobacterium smegmatis. J. Bacteriol. 2006
Interaction	PhysicalInteraction Rv2094c	active	priti.priety	2012-10-05
	Spectrophotometric Analysis JA. McDonough, KE. Hacker et al. The twin-arginine translocation pathway of Mycobacterium smegmatis is functional and required for the export of mycobacterial beta-lactamases. J. Bacteriol. 2005
Interaction	PhysicalInteraction Rv2094c	active	priti.priety	2012-10-05
	Spectrophotometric Analysis JE. Posey, TM. Shinnick et al. Characterization of the twin-arginine translocase secretion system of Mycobacterium smegmatis. J. Bacteriol. 2006
Interaction	PhysicalInteraction Rv2093c	active	ashwinigbhat	2012-10-05
	Spectrophotometric Analysis JA. McDonough, KE. Hacker et al. The twin-arginine translocation pathway of Mycobacterium smegmatis is functional and required for the export of mycobacterial beta-lactamases. J. Bacteriol. 2005
Interaction	PhysicalInteraction Rv2093c	active	ashwinigbhat	2012-10-05
	Spectrophotometric Analysis JE. Posey, TM. Shinnick et al. Characterization of the twin-arginine translocase secretion system of Mycobacterium smegmatis. J. Bacteriol. 2006
Interaction	PhysicalInteraction Rv2093c	active	priti.priety	2012-10-05
	Spectrophotometric Analysis JA. McDonough, KE. Hacker et al. The twin-arginine translocation pathway of Mycobacterium smegmatis is functional and required for the export of mycobacterial beta-lactamases. J. Bacteriol. 2005
Interaction	PhysicalInteraction Rv2093c	active	priti.priety	2012-10-05
	Spectrophotometric Analysis JE. Posey, TM. Shinnick et al. Characterization of the twin-arginine translocase secretion system of Mycobacterium smegmatis. J. Bacteriol. 2006
Interaction	PhysicalInteraction Rv1224	active	gaat3s	2012-10-05
	Spectrophotometric Analysis JA. McDonough, KE. Hacker et al. The twin-arginine translocation pathway of Mycobacterium smegmatis is functional and required for the export of mycobacterial beta-lactamases. J. Bacteriol. 2005
Interaction	PhysicalInteraction Rv1224	active	gaat3s	2012-10-05
	Spectrophotometric Analysis authors,BC. Berks,F. Sargent,T. Palmer The Tat protein export pathway. Mol. Microbiol. 2000
Interaction	PhysicalInteraction Rv1224	active	gaat3s	2012-10-05
	Spectrophotometric Analysis JE. Posey, TM. Shinnick et al. Characterization of the twin-arginine translocase secretion system of Mycobacterium smegmatis. J. Bacteriol. 2006
Interaction	PhysicalInteraction Rv0552	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometric Analysis JA. McDonough, KE. Hacker et al. The twin-arginine translocation pathway of Mycobacterium smegmatis is functional and required for the export of mycobacterial beta-lactamases. J. Bacteriol. 2005
Name	Major beta-lactamase	active	mjackson	2012-10-05
	Beta-lactamases/esterases/peptidases
Name	Major beta-lactamase	active	mjackson	2012-10-05
	Beta-lactamases/esterases/peptidases
Symbol	BlaC	active	jlew	2012-03-07
	Contains a functional tat sequence. Test for functional tat sequences using a BlaC reporter. 13 identified. JA. McDonough, JR. McCann et al. Identification of functional Tat signal sequences in Mycobacterium tuberculosis proteins. J. Bacteriol. 2008