Rv2188c - conserved hypothetical protein

Expression: Most Significant Conditions for Rv2188c

Protein Domains

Gene Information
Locus	Rv2188c
Symbol
Gene Name	conserved hypothetical protein
Location	2449993 - 2451150 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1158 bp Protein:386 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	29937
Related Genes	Acel_0972 CE2079 cg2400 DIP1620 jk0727 MAP1926c MAV_2306 Mkms_3347 ML0886 Mmcs_3285 MSMEG_4253 MT2243 MUL_3543 Mvan_3550 nfa17180 SAV6067
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2188c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2188c Transcript 1
MSRVLLVTNDFPPRRGGIQSYLGEFVGRLVGSRAHAMTVYAPQWKGADAFDDAARAAGYR
VVRHPSTVMLPGPTVDVRMRRLIAEHDIETVWFGAAAPLALLAPRARLAGASRVLASTHG
HEVGWSMLPVARSVLRRIGDGTDVVTFVSSYTRSRFASAFGPAASLEYLPPGVDTDRFRP
DPAARAELRKRYRLGERPTVVCLSRLVPRKGQDTLVTALPSIRRRVDGAALVIVGGGPYL
ETLRKLAHDCGVADHVTFTGGVATDELPAHHALADVFAMPCRTRGAGMDVEGLGIVFLEA
SAAGVPVIAGNSGGAPETVQHNKTGLVVDGRSVDRVADAVAELLIDRDRAVAMGAAGREW
VTAQWRWDTLAAKLADFLRGDDAAR*

Genomic Sequence

>Rv2188c
GTGAGCCGGGTCCTGTTGGTAACTAACGACTTTCCACCCCGACGCGGGGGCATCCAGTCC
TATCTGGGGGAGTTCGTCGGTCGGCTGGTCGGCTCCCGAGCGCATGCGATGACAGTGTAT
GCACCGCAGTGGAAAGGCGCCGACGCCTTCGACGACGCAGCCCGTGCTGCCGGTTACCGG
GTGGTGCGCCATCCCAGCACGGTGATGCTGCCGGGTCCAACGGTCGATGTCCGGATGCGC
CGGCTGATCGCCGAGCACGACATCGAAACCGTCTGGTTCGGTGCGGCCGCACCGCTGGCC
CTGCTGGCCCCGCGTGCCCGGCTGGCTGGAGCTAGCCGGGTGTTGGCCAGCACGCACGGC
CACGAAGTGGGCTGGTCGATGCTTCCGGTCGCTCGATCGGTGCTACGCCGCATCGGCGAC
GGCACCGACGTGGTGACTTTCGTCAGCAGCTACACGCGGTCCCGGTTTGCTTCTGCGTTC
GGGCCCGCGGCTTCGTTGGAATACCTACCGCCGGGAGTGGACACCGACCGGTTCCGCCCC
GATCCGGCCGCACGCGCCGAGTTGCGGAAGCGCTATCGGCTAGGCGAGCGGCCCACGGTA
GTGTGTCTGTCGCGGTTGGTGCCGCGCAAAGGCCAGGACACCCTGGTCACGGCGCTCCCG
TCGATCCGGCGTCGCGTTGATGGAGCCGCGTTGGTGATTGTCGGCGGCGGTCCATATCTA
GAGACGTTGCGCAAGCTGGCTCACGACTGTGGGGTGGCCGACCACGTGACGTTCACCGGC
GGCGTGGCAACCGACGAACTTCCCGCCCACCACGCACTGGCCGACGTGTTCGCCATGCCA
TGCCGCACCCGCGGCGCCGGGATGGACGTCGAGGGCTTGGGCATCGTGTTCCTCGAAGCC
TCCGCCGCCGGCGTGCCGGTAATCGCCGGCAATTCTGGCGGAGCGCCGGAAACGGTGCAG
CACAACAAGACTGGGCTAGTGGTCGACGGTAGGTCGGTGGACCGGGTGGCCGACGCCGTG
GCCGAGTTGCTGATCGATCGGGATCGGGCCGTCGCGATGGGCGCCGCCGGCCGAGAATGG
GTCACGGCGCAGTGGCGTTGGGACACGCTGGCCGCCAAGCTAGCAGATTTTCTGCGCGGC
GACGATGCGGCCCGTTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Name	GDP-Man-dependent alpha-1,6-phosphatidylinositol mannosyltransferase	active	mjackson	2012-10-05
	PIM, LM and LAM biosynthesis
Symbol	pimB'	active	mjackson	2012-10-05
	PIM, LM and LAM biosynthesis
Name	GDP-Man-dependent alpha-1,6-phosphatidylinositol mannosyltransferase	active	mjackson	2012-10-05
	PIM, LM and LAM biosynthesis
Symbol	pimB'	active	mjackson	2012-10-05
	PIM, LM and LAM biosynthesis
Other	TBPWY:PIM, LM and LAM biosynthesis	active	mjackson	2012-03-05
	GDP-Man-dependent alpha-1,6-phosphatidylinositol mannosyltransferase (phenotypic [corynebacterial recombinant strains]; enzymatic) ME. Guerin, D. Kaur et al. New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB' is an essential enzyme of Mycobacterium smegmatis. J. Biol. Chem. 2009
Symbol	pimB'	active	mjackson	2012-03-05
	GDP-Man-dependent alpha-1,6-phosphatidylinositol mannosyltransferase (phenotypic [corynebacterial recombinant strains]; enzymatic) ME. Guerin, D. Kaur et al. New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB' is an essential enzyme of Mycobacterium smegmatis. J. Biol. Chem. 2009
Other	TBPWY:PIM, LM and LAM biosynthesis	active	mjackson	2012-03-05
	GDP-Man-dependent alpha-1,6-phosphatidylinositol mannosyltransferase (phenotypic [corynebacterial recombinant strains]; enzymatic) AK. Mishra, S. Batt et al. Characterization of the Corynebacterium glutamiucm{Delta}pimB'{Delta}mgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologoues Rv2188c and Rv0557 in glycolipid biosynthesis. J. Bacteriol. 2009
Symbol	pimB'	active	mjackson	2012-03-05
	GDP-Man-dependent alpha-1,6-phosphatidylinositol mannosyltransferase (phenotypic [corynebacterial recombinant strains]; enzymatic) AK. Mishra, S. Batt et al. Characterization of the Corynebacterium glutamiucm{Delta}pimB'{Delta}mgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologoues Rv2188c and Rv0557 in glycolipid biosynthesis. J. Bacteriol. 2009
Other	TBPWY:PIM, LM and LAM biosynthesis	active	mjackson	2012-03-05
	GDP-Man-dependent alpha-1,6-phosphatidylinositol mannosyltransferase (phenotypic [corynebacterial recombinant strains]; enzymatic) DJ. Lea-Smith, KL. Martin et al. Analysis of a new mannosyltransferase required for the synthesis of phosphatidylinositol mannosides and lipoarbinomannan reveals two lipomannan pools in corynebacterineae. J. Biol. Chem. 2008
Symbol	pimB'	active	mjackson	2012-03-05
	GDP-Man-dependent alpha-1,6-phosphatidylinositol mannosyltransferase (phenotypic [corynebacterial recombinant strains]; enzymatic) DJ. Lea-Smith, KL. Martin et al. Analysis of a new mannosyltransferase required for the synthesis of phosphatidylinositol mannosides and lipoarbinomannan reveals two lipomannan pools in corynebacterineae. J. Biol. Chem. 2008