Rv2221c - glutamate-ammonia-ligase adenylyltransferase glnE

Expression: Most Significant Conditions for Rv2221c

Protein Domains

Gene Information
Locus	Rv2221c
Symbol	glnE
Gene Name	glutamate-ammonia-ligase adenylyltransferase glnE
Location	2489369 - 2492353 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:2985 bp Protein:995 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	861
Related Genes	Acel_0920 BL0795 CE2126 cg2446 DIP1670 jk0676 MAP1965c MAV_2245 Mkms_3389 ML1630 Mmcs_3327 MSMEG_4293 MT2279 MUL_1336 Mvan_3597 nfa16610 PPA0666 SAV5972
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2221c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2221c Transcript 1
MVVTKLATQRPKLPSVGRLGLVDPPAGERLAQLGWDRHEDQAHVDLLWSLSRAPDADAAL
RALIRLSENPDTGWDELNAALLRERSLRGRLFSVLGSSLALGDHLVAHPQSWKLLRGKVT
LPSHDQLQRSFVECVEESEGMPGSLVHRLRTQYRDYVLMLAALDLAATVEDEPVLPFTVV
AARLADAADAALAAALRVAEASVCGEHPPPRLAVIAMGKCGARELNYVSDVDVIFVAERS
DPRNARVASEMMRVASAAFFEVDAALRPEGRNGELVRTLESHIAYYQRWAKTWEFQALLK
ARPVVGDAELGERYLTALMPMVWRACEREDFVVEVQAMRRRVEQLVPADVRGRELKLGSG
GLRDVEFAVQLLQLVHARSDESLRVASTVDALAALGEGGYIGREDAANMTASYEFLRLLE
HRLQLQRLKRTHLLPDPEDEEAVRWLARAAHIRPDGRNDAAGVLREELKKQNVRVSKLHT
KLFYQPLLESIGPTGLEIAHGMTLEAAGRRLAALGYEGPQTALKHMSALVNQSGRRGRVQ
SVLLPRLLDWMSYAPDPDGGLLAYRRLSEALATESWYLATLRDKPAVAKRLMHVLGTSAY
VPDLLMRAPRVIQQYEDGPAGPKLLETEPAAVARALIASASRYPDPERAIAGARTLRRRE
LARIGSADLLGLLEVTEVCRALTSVWVAVLQAALDVMIRASLPDDDRAPAAIAVIGMGRL
GGAELGYGSDADVMFVCEPATGVDDARAVKWSTSIAERVRALLGTPSVDPPLELDANLRP
EGRNGPLVRTLGSYAAYYEQWAQPWEIQALLRAHAVAGDAELGQRFLRMVDKTRYPPDGV
SADSVREIRRIKARIESERLPRGADPNTHTKLGRGGLADIEWTVQLLQLQHAHQVPALHN
TSTLQSLDVIAAADLVPAADVELLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVA
VAAGWRNDDGGEFLDNYLRVTRRAKAVVRKVFGS*

Genomic Sequence

>Rv2221c
GTGGTCGTGACCAAACTCGCCACGCAGCGGCCGAAGTTGCCCAGCGTTGGCCGGCTCGGA
TTAGTTGACCCCCCTGCTGGTGAGCGTCTGGCTCAGCTGGGGTGGGATCGGCACGAGGAT
CAGGCGCACGTCGACCTGCTGTGGTCGCTGTCACGCGCTCCGGACGCCGATGCCGCGCTG
CGCGCCTTGATCCGGCTGTCGGAGAATCCAGACACCGGATGGGACGAGCTCAACGCGGCT
CTGCTGCGCGAACGCAGTCTGCGCGGGCGGCTGTTCTCGGTGCTGGGCTCGTCGCTGGCG
TTGGGCGATCACCTGGTCGCCCATCCGCAGTCCTGGAAATTGCTGCGGGGCAAGGTCACA
CTGCCGTCCCATGACCAGCTGCAGCGGTCGTTCGTCGAGTGCGTCGAGGAATCGGAGGGT
ATGCCGGGCTCGCTCGTGCACCGATTGCGAACCCAGTACCGCGACTACGTGCTAATGCTG
GCCGCTCTCGACCTGGCCGCGACGGTCGAGGACGAACCGGTGCTGCCATTCACCGTGGTG
GCCGCACGCCTGGCGGACGCCGCGGACGCCGCTCTGGCGGCGGCGCTGCGCGTGGCCGAG
GCGAGCGTGTGCGGCGAGCACCCGCCACCGCGCCTGGCGGTCATCGCGATGGGCAAGTGC
GGTGCGCGCGAACTGAACTACGTCAGCGACGTCGATGTCATATTCGTTGCCGAGCGCTCC
GACCCGCGCAACGCGCGCGTGGCCAGCGAGATGATGCGGGTGGCCTCGGCGGCCTTTTTC
GAGGTGGACGCCGCCCTGCGTCCGGAGGGGCGCAACGGGGAGCTGGTCCGTACGCTCGAG
TCGCACATCGCCTACTACCAGCGCTGGGCCAAGACCTGGGAGTTTCAGGCGTTGCTGAAA
GCACGGCCAGTCGTTGGCGACGCGGAACTTGGCGAGCGTTACCTGACCGCCTTGATGCCG
ATGGTGTGGCGAGCCTGCGAGCGCGAAGACTTTGTGGTCGAGGTGCAGGCCATGCGGCGG
CGGGTGGAGCAGCTGGTGCCCGCCGATGTCCGCGGCCGCGAGCTCAAACTCGGCAGCGGC
GGATTGCGCGACGTGGAGTTCGCCGTACAGCTACTGCAGCTGGTTCATGCCCGTAGCGAC
GAGTCGTTACGGGTGGCGTCCACGGTGGACGCATTGGCGGCGTTGGGCGAAGGCGGCTAC
ATCGGGCGTGAGGACGCGGCGAACATGACCGCGTCGTATGAGTTCCTCAGGCTGCTCGAG
CACCGACTGCAGTTGCAGCGGCTCAAGCGCACCCACCTGCTTCCCGATCCCGAAGACGAG
GAGGCAGTGCGCTGGCTGGCGCGCGCGGCCCACATCCGGCCCGATGGCCGAAACGATGCG
GCCGGGGTGCTGCGGGAGGAACTCAAGAAGCAGAACGTGCGGGTGTCGAAGTTACACACC
AAACTCTTCTATCAACCGCTGCTGGAATCGATCGGCCCGACCGGGTTGGAGATCGCCCAC
GGCATGACGTTGGAGGCCGCGGGGCGCCGGCTGGCCGCGCTGGGCTACGAGGGACCGCAG
ACCGCGTTGAAACACATGTCGGCGTTGGTCAATCAAAGCGGCCGGCGCGGACGGGTGCAG
TCGGTGCTGCTGCCCAGGCTGCTGGACTGGATGTCGTATGCCCCCGATCCCGACGGCGGA
CTGCTGGCCTACCGGCGGCTCAGTGAGGCGCTGGCCACCGAAAGCTGGTACCTGGCCACG
CTGCGGGACAAGCCCGCGGTGGCCAAGCGGCTCATGCATGTCTTGGGTACCTCGGCGTAT
GTGCCGGATCTGTTGATGCGCGCGCCGCGGGTCATCCAGCAGTACGAGGACGGGCCTGCG
GGCCCGAAGCTGCTCGAGACCGAGCCCGCCGCCGTGGCTCGGGCGCTGATCGCCTCGGCG
AGCCGCTACCCCGACCCGGAGCGGGCCATCGCCGGCGCGCGCACGCTGCGTCGTCGAGAG
CTGGCCCGCATCGGTTCGGCGGACCTGCTCGGCCTGCTCGAGGTCACCGAGGTGTGCCGG
GCGTTGACGTCGGTGTGGGTGGCGGTGCTGCAGGCCGCGCTGGACGTCATGATCCGGGCC
AGCCTTCCCGACGACGATCGCGCCCCGGCGGCCATCGCGGTCATCGGCATGGGTCGGCTG
GGTGGTGCCGAGTTGGGCTACGGGTCGGATGCCGACGTGATGTTCGTCTGTGAGCCGGCC
ACCGGCGTCGACGATGCACGGGCGGTGAAATGGTCGACATCGATCGCCGAGCGGGTTCGG
GCGCTGCTGGGGACACCCAGCGTCGATCCGCCGCTGGAGCTCGACGCCAATTTGCGACCC
GAGGGCCGCAACGGTCCGCTGGTCCGCACCCTGGGGTCCTACGCCGCATACTACGAGCAG
TGGGCACAGCCATGGGAGATCCAGGCCCTGCTACGCGCACACGCGGTTGCCGGCGATGCC
GAGTTGGGTCAGCGATTCCTACGGATGGTCGACAAAACGCGGTATCCGCCCGACGGTGTG
TCCGCTGACTCGGTGCGCGAGATTCGCCGCATCAAGGCCCGTATCGAGTCCGAGCGGTTG
CCGCGCGGTGCCGACCCCAACACACACACCAAACTGGGCCGCGGCGGACTGGCCGACATC
GAATGGACCGTGCAGTTGCTGCAGCTACAGCATGCGCACCAGGTTCCCGCCCTGCACAAC
ACCTCGACGCTGCAATCCCTGGATGTCATCGCGGCCGCCGATCTGGTTCCCGCAGCCGAC
GTGGAGCTGCTCCGTCAGGCCTGGCTGACCGCCACCCGGGCCCGCAACGCGCTGGTGTTG
GTGCGCGGCAAGCCCACCGACCAGCTGCCGGGACCCGGGCGCCAGCTCAATGCGGTCGCG
GTCGCGGCCGGCTGGCGAAACGACGACGGTGGGGAATTCCTGGACAACTACCTACGGGTG
ACGCGGCGGGCAAAGGCGGTAGTGCGCAAAGTGTTCGGGAGTTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Operon Rv2919c	active	shahanup86	2012-10-05
	Coexpression(Functional Linkage) A. Bandyopadhyay, A. Arora et al. Expression and molecular characterization of the Mycobacterium tuberculosis PII protein. J. Biochem. 2010
Interaction	Operon Rv2919c	active	shahanup86	2012-10-05
	Coexpression(Functional Linkage) R. Read, CA. Pashley et al. The role of GlnD in ammonia assimilation in Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland) 2007
Interaction	Transcription Rv2220	active	jgalag	2012-10-05
	Structural Analysis GS. Hotter, P. Mouat et al. Independent transcription of glutamine synthetase (glnA2) and glutamine synthetase adenylyltransferase (glnE) in Mycobacterium bovis and Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland) 2008
Interaction	Transcription Rv2220	active	jgalag	2012-10-05
	Structural Analysis authors,WW. Krajewski,TA. Jones,SL. Mowbray Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights. Proc. Natl. Acad. Sci. U.S.A. 2005
Interaction	Transcription Rv2220	active	jgalag	2012-10-05
	Structural Analysis R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
Interaction	Transcription Rv2220	active	jgalag	2012-10-05
	Spectrophotometric GS. Hotter, P. Mouat et al. Independent transcription of glutamine synthetase (glnA2) and glutamine synthetase adenylyltransferase (glnE) in Mycobacterium bovis and Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland) 2008
Interaction	Transcription Rv2220	active	jgalag	2012-10-05
	Spectrophotometric authors,WW. Krajewski,TA. Jones,SL. Mowbray Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights. Proc. Natl. Acad. Sci. U.S.A. 2005
Interaction	Transcription Rv2220	active	jgalag	2012-10-05
	Spectrophotometric R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001