Rv2223c - exported protease

Expression: Most Significant Conditions for Rv2223c

Protein Domains

Gene Information
Locus	Rv2223c
Symbol
Gene Name	exported protease
Location	2493837 - 2495399 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1563 bp Protein:521 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	28765
Related Genes	CE1275 cg1332 MAP1967c MAP1968c MAV_2241 MAV_2243 Mkms_3391 Mkms_3392 ML1632 ML1633 Mmcs_3329 Mmcs_3330 MSMEG_4295 MSMEG_4296 MT2281 MT2282 MUL_1332 MUL_1334 MUL_3101 Mvan_3599 Mvan_3600 nfa16590 nfa55080 Rv2224c
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2223c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2223c Transcript 1
MAAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQTPGAPVVAPQQSWNSCRE
FIADTSEIRTARCATVSVPVDYDQPGGTQAKLAVIRVPATGQRFGALLVNPGGPGASAVD
MVAAMAPAIADTDILRHFDLVGFDPRGVGHSTPALRCRTDAEFDAYRRDPMADYSPAGVT
HVEQVYRQLAQDCVDRMGFSFLANIGTASVARDMDMVRQALGDDQINYLGYSYGTELGTA
YLERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQTAFNDYAADCARSPACPLGTDSAQ
WVNRYHALVDPLVQKPGKTSDPRGLSYADATTGTINALYSPQRWKYLTSGLLGLQRGSDA
GDLLVLADDYDGRDADGHYSNDQDAFNAVRCVDAPTPADPAAWVAADQRIRQVAPFLSYG
QFTGSAPRDLCALWPVPATSTPHPAAPAGAGKVVVVSTTHDPATPYQSGVDLARQLGAPL
ITFDGTQHTAVFDGNQCVDSAVMHYFLDGTLPPTSLRCAP*

Genomic Sequence

>Rv2223c
ATGGCGGCCATGTGGCGCCGCAGACCGTTGAGCTCGGCGCTGCTGTCCTTCGGGTTGCTG
CTCGGCGGACTGCCCCTAGCAGCGCCCCCGTTGGCCGGCGCGACTGAAGAACCCGGCGCC
GGCCAAACCCCGGGTGCGCCGGTCGTGGCGCCGCAACAGAGTTGGAACAGCTGCCGCGAG
TTCATCGCCGACACCAGCGAAATTCGCACTGCACGCTGCGCGACGGTGTCCGTCCCCGTC
GACTACGACCAACCCGGTGGGACACAAGCGAAGTTGGCGGTGATCCGCGTCCCCGCGACG
GGACAGCGATTCGGAGCACTGCTGGTCAATCCTGGGGGACCCGGGGCGTCGGCGGTCGAC
ATGGTCGCCGCTATGGCACCCGCGATCGCCGACACCGACATTCTCCGCCACTTCGACCTG
GTGGGCTTCGACCCGAGAGGGGTCGGCCACTCGACCCCTGCGTTGCGGTGTCGCACCGAC
GCCGAGTTCGACGCGTACCGGCGCGATCCGATGGCCGACTACAGTCCGGCCGGTGTCACC
CACGTCGAACAGGTCTACCGGCAGTTGGCCCAGGACTGTGTTGACCGGATGGGCTTCAGC
TTCTTGGCCAATATCGGTACCGCGTCCGTCGCACGGGACATGGACATGGTTCGCCAAGCG
TTAGGTGACGATCAGATCAACTACCTCGGATACAGCTACGGCACCGAGTTGGGCACCGCT
TACCTGGAACGGTTCGGTACTCATGTGCGGGCGATGGTCCTCGACGGCGCTATCGATCCA
GCCGTTAGCCCAATCGAGGAAAGCATCAGCCAAATGGCGGGATTTCAGACCGCTTTCAAT
GACTACGCCGCCGACTGCGCCCGCTCGCCGGCCTGCCCTCTGGGCACCGACTCGGCCCAG
TGGGTCAACCGCTACCACGCCCTGGTTGACCCGCTGGTGCAGAAGCCGGGTAAGACGTCG
GATCCACGTGGCCTGAGCTACGCCGACGCGACGACGGGCACCATCAACGCGCTGTACAGC
CCTCAGCGCTGGAAGTACCTGACCAGTGGTCTGCTGGGGCTGCAGCGCGGCAGCGACGCC
GGCGACTTGCTGGTGCTTGCCGACGACTATGACGGCCGGGATGCAGACGGGCACTACAGC
AACGACCAGGACGCGTTCAACGCGGTCCGGTGCGTCGATGCGCCCACACCGGCCGATCCA
GCGGCCTGGGTGGCCGCCGACCAACGGATCCGTCAGGTCGCCCCGTTCCTTAGCTACGGG
CAGTTCACCGGATCCGCCCCCCGCGATCTGTGCGCGCTGTGGCCGGTGCCGGCAACGTCG
ACGCCGCACCCCGCGGCGCCGGCCGGGGCTGGCAAGGTCGTCGTGGTGTCCACCACCCAC
GACCCGGCCACTCCGTATCAGTCCGGGGTAGACCTGGCCCGCCAGCTGGGCGCACCGCTG
ATCACCTTCGACGGCACCCAACACACTGCGGTGTTCGATGGCAACCAGTGTGTGGACTCT
GCGGTGATGCACTATTTTCTCGACGGGACCTTGCCGCCGACGAGTCTGCGGTGCGCGCCC
TGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv2224c	active	shahanup86	2012-10-05
	Operon (Functional linkage) AR. Flores, LM. Parsons et al. Characterization of novel Mycobacterium tuberculosis and Mycobacterium smegmatis mutants hypersusceptible to beta-lactam antibiotics. J. Bacteriol. 2005
Interaction	Regulatory Rv2224c	active	shahanup86	2012-10-05
	Operon (Functional linkage) J. Rengarajan, E. Murphy et al. Mycobacterium tuberculosis Rv2224c modulates innate immune responses. Proc. Natl. Acad. Sci. U.S.A. 2008
Interaction	Regulatory Rv2224c	active	shahanup86	2012-10-05
	Operon (Functional linkage) AR. Flores, LM. Parsons et al. Characterization of novel Mycobacterium tuberculosis and Mycobacterium smegmatis mutants hypersusceptible to beta-lactam antibiotics. J. Bacteriol. 2005
Interaction	Regulatory Rv2224c	active	shahanup86	2012-10-05
	Operon (Functional linkage) J. Rengarajan, E. Murphy et al. Mycobacterium tuberculosis Rv2224c modulates innate immune responses. Proc. Natl. Acad. Sci. U.S.A. 2008