Rv2224c - exported protease

Expression: Most Significant Conditions for Rv2224c

Protein Domains

Gene Information
Locus	Rv2224c
Symbol
Gene Name	exported protease
Location	2495461 - 2497023 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1563 bp Protein:521 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	28765
Related Genes	CE1275 cg1332 MAP1967c MAP1968c MAV_2241 MAV_2243 Mkms_3391 Mkms_3392 ML1632 ML1633 Mmcs_3329 Mmcs_3330 MSMEG_4295 MSMEG_4296 MT2281 MT2282 MUL_1332 MUL_1334 MUL_3101 Mvan_3599 Mvan_3600 nfa16590 nfa55080 Rv2223c
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2224c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2224c Transcript 1
MGMRLSRRDKIARMLLIWAALAAVALVLVGCIRVVGGRARMAEPKLGQPVEWTPCRSSNP
QVKIPGGALCGKLAVPVDYDRPDGDVAALALIRFPATGDKIGSLVINPGGPGESGIEAAL
GVFQTLPKRVHERFDLVGFDPRGVASSRPAIWCNSDADNDRLRAEPQVDYSREGVAHIEN
ETKQFVGRCVDKMGKNFLAHVGTVNVAKDLDAIRAALGDDKLTYLGYSYGTRIGSAYAEE
FPQRVRAMILDGAVDPNADPIEAELRQAKGFQDAFNNYAADCAKNAGCPLGADPAKAVEV
YHSLVDPLVDPDNPRISRPARTKDPRGLSYSDAIVGTIMALYSPNLWQHLTDGLSELVDN
RGDTLLALADMYMRRDSHGRYNNSGDARVAINCVDQPPVTDRDKVIDEDRRAREIAPFMS
YGKFTGDAPLGTCAFWPVPPTSQPHAVSAPGLVPTVVVSTTHDPATPYKAGVDLANQLRG
SLLTFDGTQHTVVFQGDSCIDEYVTAYLIGGTTPPSGAKC*

Genomic Sequence

>Rv2224c
GTGGGCATGAGGCTGTCTCGCCGCGACAAGATCGCGCGCATGCTGTTGATCTGGGCCGCG
CTCGCCGCCGTGGCGTTGGTTCTTGTGGGCTGCATCCGCGTGGTCGGGGGACGCGCTCGT
ATGGCGGAGCCGAAGCTGGGCCAGCCGGTGGAGTGGACACCGTGCCGGTCGTCAAACCCG
CAAGTAAAGATCCCCGGCGGCGCGTTATGCGGCAAGCTCGCTGTACCGGTCGACTACGAC
CGCCCCGATGGTGACGTGGCGGCGCTGGCGCTGATTCGCTTTCCGGCGACGGGAGACAAG
ATCGGTTCGCTGGTCATAAATCCCGGTGGACCCGGCGAATCCGGTATCGAGGCCGCCTTG
GGCGTCTTCCAGACATTGCCGAAGCGGGTGCACGAAAGGTTCGACCTGGTTGGGTTCGAC
CCCCGCGGGGTGGCGTCGTCCCGGCCGGCGATCTGGTGCAACTCCGATGCCGACAACGAC
CGGCTGCGGGCCGAGCCGCAGGTTGACTACAGCCGGGAGGGTGTGGCGCACATCGAGAAC
GAGACCAAGCAATTCGTCGGTCGCTGTGTGGACAAGATGGGCAAGAACTTTCTGGCCCAT
GTCGGGACGGTCAACGTCGCCAAGGACCTGGATGCCATTCGCGCGGCGTTGGGCGACGAC
AAGCTGACCTACCTGGGCTACTCGTACGGCACCCGGATCGGCTCCGCGTATGCCGAGGAA
TTTCCGCAGCGGGTGCGGGCAATGATTCTCGACGGTGCCGTCGACCCCAATGCCGATCCC
ATCGAGGCGGAGCTGCGCCAGGCCAAGGGCTTCCAGGACGCGTTCAACAACTATGCCGCC
GACTGCGCCAAGAACGCGGGCTGCCCGCTGGGCGCCGACCCGGCCAAAGCCGTCGAGGTC
TACCACAGCCTGGTCGATCCGTTGGTCGACCCGGACAACCCGAGGATCAGCAGGCCGGCG
CGCACGAAGGATCCGCGCGGGCTGAGTTATAGCGACGCCATCGTGGGCACCATTATGGCG
CTGTACTCACCGAATCTGTGGCAACACTTGACCGACGGGCTGTCGGAGCTGGTCGACAAT
CGCGGAGACACCCTGCTGGCTCTGGCCGACATGTACATGCGTCGGGACTCGCACGGCCGC
TACAACAATTCCGGTGACGCGCGGGTGGCGATCAATTGCGTCGATCAGCCCCCGGTTACC
GATCGCGACAAGGTCATCGACGAAGACCGCCGCGCCCGGGAGATCGCACCGTTCATGAGC
TACGGGAAGTTCACCGGTGATGCGCCGCTGGGCACCTGCGCGTTCTGGCCGGTGCCACCC
ACAAGTCAGCCCCATGCCGTCTCGGCGCCCGGCCTAGTGCCGACGGTGGTGGTATCCACC
ACCCATGACCCGGCGACGCCGTACAAGGCCGGGGTCGACCTGGCGAACCAGCTTCGCGGT
TCGTTGCTGACCTTCGACGGAACCCAGCACACGGTGGTATTCCAGGGCGACAGCTGCATT
GACGAGTACGTGACGGCGTATTTAATCGGCGGCACCACGCCGCCCAGCGGCGCCAAGTGC
TAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Degradation Rv0440	active	priti.priety	2012-10-05
	Affinity purification (Physical interaction) AR. Flores, LM. Parsons et al. Characterization of novel Mycobacterium tuberculosis and Mycobacterium smegmatis mutants hypersusceptible to beta-lactam antibiotics. J. Bacteriol. 2005
Interaction	Degradation Rv0440	active	priti.priety	2012-10-05
	Affinity purification (Physical interaction) J. Rengarajan, E. Murphy et al. Mycobacterium tuberculosis Rv2224c modulates innate immune responses. Proc. Natl. Acad. Sci. U.S.A. 2008
Interaction	Regulatory Rv2223c	active	shahanup86	2012-10-05
	Operon (Functional linkage) AR. Flores, LM. Parsons et al. Characterization of novel Mycobacterium tuberculosis and Mycobacterium smegmatis mutants hypersusceptible to beta-lactam antibiotics. J. Bacteriol. 2005
Interaction	Regulatory Rv2223c	active	shahanup86	2012-10-05
	Operon (Functional linkage) J. Rengarajan, E. Murphy et al. Mycobacterium tuberculosis Rv2224c modulates innate immune responses. Proc. Natl. Acad. Sci. U.S.A. 2008
Interaction	Regulatory Rv2223c	active	shahanup86	2012-10-05
	Operon (Functional linkage) AR. Flores, LM. Parsons et al. Characterization of novel Mycobacterium tuberculosis and Mycobacterium smegmatis mutants hypersusceptible to beta-lactam antibiotics. J. Bacteriol. 2005
Interaction	Regulatory Rv2223c	active	shahanup86	2012-10-05
	Operon (Functional linkage) J. Rengarajan, E. Murphy et al. Mycobacterium tuberculosis Rv2224c modulates innate immune responses. Proc. Natl. Acad. Sci. U.S.A. 2008