Rv2379c - peptide synthetase mbtF

Expression: Most Significant Conditions for Rv2379c

Protein Domains

Gene Information
Locus	Rv2379c
Symbol	mbtF
Gene Name	peptide synthetase mbtF
Location	2657700 - 2662085 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:4386 bp Protein:1462 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	31580
Related Genes	MAP2171c MAV_2014 Mkms_3528 Mmcs_3465 MSMEG_4510 MT2447 MUL_3633 Mvan_3844 nfa7670
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2379c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2379c Transcript 1
MGPVAVTRADARGAIDDVMALSPLQQGLFSRATLVAAESGSEAAEADPYVIAMAADAAGP
LDIALLRDCAAAMLTRHPNLRASFLHGNLSRPVQVIPSSAEVLWRHVRAHPSEVGALAAE
ERRRRFDVGRGPLIRFLLIELPDECWHLVIVAHHIVIDGWSLPLFVSELLALYRAGGHVA
ALPAAPRPYRDYIGWLAGRDQTASRAMWADHLNGLDGPTLLSPALADTPVQPGIPGRTEV
RLDREATAELADAARTRGVTISTLVQMAWATTLSAFTGRGDVTFGVTVSGRPSELSGVET
MIGLFINTVPLRVRLDARATVGGQCAVLQRQFAMLRDHSYLGFNEFRAIAGIGEMFDTLL
VYENFPPGEVVGTAEFVANGVTFRPVALESLSHFPVTVAAHRSTGELTLLVEVLDGALGT
MAPESLGRRVLAVLQRLVSRWDRPLRDVDILLDGEHDPTAPGLPDVTTSAPAVHTRFAEI
AAAQPDSVAVSWADGQLTYRELDALADRLATGLRRADVSRETPVAVALSRGPRYVAAMLA
VLKAGGMIVPLDPAMPGERVAEILRQTSAPVVIDEGVFAASVGADILEEDRAITVPVDQA
AYVIFTSGTTGTPKGVIGTHRALSAYADDHIERVLRPAAQRLGRPLRIAHAWSFTFDAAW
QPLVALLDGHAVHIVDDHRQRDAGALVEAIDRFGLDMIDTTPSMFAQLHNAGLLDRAPLA
VLALGGEALGAATWRMIQQNCARTAMTAFNCYGPTETTVEAVVAAVAEHARPVIGRPTCT
TRAYVMDSWLRPVPDGVAGELYLAGAQLTRGYLGRPAETAARFVAEPNGRGSRMYRTGDV
VRRLPDGGLEFLGRSDDQVKIRGFRVEPGEIAAVLNGHHAVHGCHVTARGHASGPRLTAY
VAGGPQPPPVAELRAMLLERLPRYLVPHHIVVLDELPLTPHGKIDENALAAINVTEGPAT
PPQTPTELVLAEAFADVMETSNVDVTAGFLQMGLDSIVALSVVQAARRRGIALRARLMVE
CDTIRELAAAIDSDAAWQAPANDAGEPIPVLPNTHWLYEYGDPRRLAQTEVIRLPDRITR
ERLDAVLAAVVDGHEVLRCRFDRDAMALVAQPKTDILSEVWVSGELVTAVAEQTLGALAS
LDPQAGRLLSAVWLREPDGPGVLVLTAHVLAMDPASWRIVLGELDAGLHALAAGRAPSPA
RENTSYRQWSRLLAQRAKALDSVDFWVAELEGADPPLGARRVAPQTDRVGELAITMSISD
ADLTARLLSTGRSMTDLLATAAARMVTAWRRQRGQQTPAPLLALETHGRADVHVDKTADT
SDTVGLLSAIYPLRIHCDGATDFARIPGSGIDYGLLRYLRADTAERLRAHREPQLLLNYL
GSLHVGVGDLAVDRALLADVGQLPEPEQPVRHELTVLAALLGPADAPVLATRWRTLPDIL
SADDVATLQSLWQGALAEITA*

Genomic Sequence

>Rv2379c
ATGGGACCAGTGGCCGTGACGCGAGCCGACGCGCGGGGCGCCATCGACGATGTGATGGCG
CTCAGCCCATTGCAACAGGGACTGTTTTCTAGGGCGACACTGGTCGCCGCGGAGTCCGGC
TCTGAGGCCGCAGAGGCCGACCCGTATGTGATCGCGATGGCGGCCGACGCGGCCGGCCCG
CTCGACATCGCCTTGCTTCGCGACTGCGCTGCCGCGATGCTGACCCGGCACCCCAACCTG
CGGGCGAGCTTCCTACACGGGAACCTGAGCCGGCCCGTGCAGGTAATACCATCCAGTGCC
GAGGTGCTTTGGCGTCACGTGCGCGCCCACCCCAGTGAGGTCGGGGCGCTGGCAGCCGAA
GAGCGCCGGCGCCGCTTCGACGTCGGCCGCGGACCACTCATCCGGTTCCTGCTCATCGAA
CTACCGGACGAATGTTGGCATCTGGTCATCGTCGCGCACCACATCGTCATCGACGGATGG
TCGTTGCCGCTGTTCGTCTCCGAGCTGCTCGCCTTGTATCGGGCTGGTGGTCACGTCGCC
GCGTTGCCGGCAGCGCCGCGGCCGTATCGCGACTACATCGGCTGGCTGGCCGGCCGCGAT
CAGACGGCTAGCCGCGCAATGTGGGCGGACCACCTCAATGGCCTGGACGGCCCGACTCTG
TTATCGCCGGCACTCGCCGACACTCCTGTGCAGCCGGGTATTCCGGGACGCACCGAAGTG
CGCCTTGACCGTGAAGCCACCGCGGAGCTGGCCGATGCCGCCCGCACCCGTGGCGTCACG
ATCAGCACACTTGTTCAAATGGCTTGGGCTACCACGCTTTCAGCATTCACCGGTCGTGGC
GATGTGACGTTCGGTGTGACGGTGTCCGGCAGGCCCAGCGAACTGTCCGGCGTGGAAACG
ATGATCGGCCTGTTCATCAATACGGTGCCACTGCGGGTCCGCCTGGACGCCCGCGCTACC
GTCGGCGGGCAATGCGCTGTCCTACAACGTCAATTCGCCATGTTGCGCGACCACAGCTAT
CTCGGTTTCAACGAGTTTCGTGCCATCGCCGGTATCGGTGAGATGTTCGACACCCTACTG
GTGTATGAGAACTTCCCGCCCGGCGAGGTGGTGGGCACCGCGGAGTTCGTCGCAAACGGG
GTGACGTTCCGTCCGGTGGCGCTAGAGAGTTTGTCGCACTTTCCGGTGACCGTCGCCGCG
CACCGCAGCACCGGTGAGCTCACGCTGCTAGTGGAGGTGCTCGACGGTGCGCTGGGCACG
ATGGCGCCCGAAAGCCTCGGCAGGCGGGTGCTGGCTGTGTTACAGCGCTTGGTCAGCCGG
TGGGATCGGCCGCTGCGCGACGTCGACATTCTGCTGGACGGCGAGCACGATCCGACCGCA
CCCGGCCTGCCGGATGTGACGACGTCGGCACCCGCGGTGCATACCCGGTTCGCCGAAATC
GCTGCGGCACAGCCTGACTCGGTGGCGGTCAGTTGGGCGGATGGTCAGCTGACGTACCGG
GAGCTGGATGCATTGGCCGACCGGCTGGCCACTGGGCTGCGCCGCGCGGACGTGAGTCGC
GAGACCCCGGTGGCCGTCGCGCTGTCCCGTGGTCCGCGCTACGTGGCCGCCATGCTGGCG
GTCCTCAAGGCGGGTGGCATGATCGTGCCGCTGGACCCGGCGATGCCCGGTGAGCGTGTC
GCCGAGATCTTGCGCCAGACATCGGCTCCGGTGGTCATCGATGAGGGCGTGTTCGCCGCT
TCGGTTGGCGCTGACATACTCGAGGAGGACCGTGCCATCACGGTGCCGGTGGACCAGGCG
GCCTACGTGATTTTCACCTCCGGCACCACCGGTACCCCGAAAGGTGTCATCGGCACCCAT
CGGGCGCTGTCGGCCTACGCCGACGACCACATCGAGCGCGTGTTGCGGCCGGCGGCCCAG
CGGCTCGGGCGCCCGCTGCGAATCGCGCATGCCTGGTCGTTCACCTTCGACGCGGCGTGG
CAGCCGTTGGTCGCACTGCTTGACGGCCACGCGGTGCACATTGTCGACGACCATCGTCAG
CGGGACGCAGGGGCGCTGGTCGAAGCGATCGACCGATTCGGTCTGGACATGATTGACACC
ACGCCGTCGATGTTCGCCCAGCTGCACAACGCTGGACTGCTCGACCGGGCGCCGTTGGCG
GTGCTTGCGCTCGGCGGCGAAGCCTTGGGCGCCGCGACGTGGCGGATGATCCAGCAGAAC
TGCGCGCGCACGGCCATGACGGCCTTCAACTGCTACGGGCCTACCGAGACCACGGTCGAA
GCCGTGGTCGCCGCCGTTGCTGAGCATGCGCGACCGGTCATCGGACGTCCGACCTGCACC
ACCCGCGCCTACGTCATGGACTCCTGGCTGCGGCCGGTGCCCGATGGCGTCGCCGGCGAG
CTGTATCTGGCGGGCGCCCAGTTGACCCGCGGTTACCTCGGCCGCCCGGCCGAGACTGCG
GCGCGCTTTGTCGCTGAGCCAAACGGGCGCGGTAGCCGAATGTACCGCACCGGAGATGTG
GTGCGCCGCCTGCCCGACGGTGGACTGGAGTTCCTCGGGCGCAGCGATGACCAGGTGAAG
ATCCGCGGTTTCCGCGTCGAGCCGGGTGAGATTGCCGCGGTGCTCAACGGCCACCATGCG
GTGCACGGTTGCCATGTGACGGCCCGCGGCCATGCCAGTGGCCCCCGGCTGACGGCGTAT
GTGGCAGGCGGACCACAACCGCCACCGGTGGCCGAATTGCGGGCGATGCTGCTAGAGCGG
TTGCCGCGTTATCTAGTCCCGCACCATATCGTCGTCCTCGACGAGTTACCGCTGACTCCA
CACGGCAAGATCGACGAAAACGCTTTGGCGGCAATCAATGTCACCGAAGGACCGGCAACT
CCGCCGCAGACACCGACCGAGCTGGTGCTGGCCGAGGCGTTCGCCGATGTCATGGAAACC
TCGAACGTCGATGTCACCGCGGGCTTTTTGCAGATGGGTCTAGACAGCATCGTGGCGCTG
TCGGTGGTGCAGGCCGCGCGCCGTCGTGGGATTGCGTTGCGGGCCAGGCTGATGGTGGAG
TGCGACACCATCCGTGAACTCGCGGCGGCCATTGACTCCGATGCCGCATGGCAGGCACCG
GCCAACGATGCCGGCGAGCCGATCCCGGTGCTACCCAACACTCATTGGCTCTACGAGTAC
GGCGACCCGCGCCGGCTGGCACAAACCGAGGTCATCAGGTTGCCCGACCGGATCACCCGC
GAACGCCTGGATGCCGTGTTGGCCGCGGTCGTCGACGGACACGAGGTGTTGCGGTGCCGG
TTCGACCGGGATGCGATGGCCCTTGTCGCACAACCGAAAACGGACATTCTCAGCGAGGTT
TGGGTCAGCGGTGAACTGGTCACCGCGGTGGCCGAGCAGACTCTTGGCGCGCTGGCGAGT
CTCGACCCCCAGGCCGGCCGACTGCTCTCGGCGGTGTGGCTGCGCGAACCCGACGGGCCC
GGTGTTCTGGTGCTGACCGCCCATGTGCTGGCGATGGACCCAGCCTCCTGGCGGATTGTG
CTGGGTGAACTCGACGCCGGCCTGCACGCGCTGGCGGCCGGGCGCGCGCCCAGCCCAGCG
CGCGAGAACACCAGCTACCGGCAGTGGTCGCGGCTGCTGGCGCAGCGGGCTAAGGCGCTG
GATAGCGTTGATTTCTGGGTCGCCGAACTCGAGGGCGCCGATCCGCCGTTGGGTGCCCGC
AGGGTGGCGCCGCAGACCGACCGGGTTGGTGAGCTAGCGATCACCATGTCGATCTCCGAC
GCCGATCTGACCGCGCGGCTGCTTTCGACGGGACGGTCGATGACCGATCTGCTGGCTACC
GCCGCTGCGCGGATGGTGACCGCCTGGCGCCGGCAACGCGGTCAACAAACACCAGCACCG
CTGTTGGCGTTGGAGACGCATGGCCGCGCGGACGTCCACGTCGATAAGACTGCCGACACC
AGCGACACGGTCGGGCTGCTCAGCGCGATCTATCCGCTGCGCATCCACTGCGACGGCGCG
ACCGACTTCGCGCGGATACCCGGCAGCGGCATCGATTACGGCCTGCTGCGGTACCTGCGC
GCCGATACCGCGGAGCGACTACGCGCCCACCGCGAACCCCAGCTGCTGCTGAACTATCTG
GGTAGCCTGCACGTCGGGGTGGGAGATCTGGCGGTCGACCGCGCACTACTGGCTGATGTG
GGGCAACTGCCTGAACCCGAACAGCCGGTGCGCCACGAACTGACGGTGCTGGCGGCGCTC
CTCGGGCCCGCCGACGCTCCCGTGCTAGCCACGCGGTGGCGCACGCTGCCCGACATCCTG
TCCGCCGACGACGTCGCCACGCTGCAATCACTGTGGCAGGGCGCGCTGGCGGAGATAACA
GCATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:MCBTS3 carboxymycobactin synthesis - IDA	active	njamshidi	2012-10-05
	For carboxymycobactin see PMID: 7761471, also Cole et al text: Tuberculosis and the Tubercle Bacillus - R group length varies from 2-9 carbons - cmcbtt has 8C tail w/ last carbon fully oxidized to carboxyl group. Will add methyl ester form for current version. See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	EC:6.2.1.13 Acetate--CoA ligase (ADP-forming). - IDA	active	njamshidi	2012-10-05
	For carboxymycobactin see PMID: 7761471, also Cole et al text: Tuberculosis and the Tubercle Bacillus - R group length varies from 2-9 carbons - cmcbtt has 8C tail w/ last carbon fully oxidized to carboxyl group. Will add methyl ester form for current version. See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	TBRXN:MCBTS3 carboxymycobactin synthesis - IDA	active	njamshidi	2012-10-05
	For carboxymycobactin see PMID: 7761471, also Cole et al text: Tuberculosis and the Tubercle Bacillus - R group length varies from 2-9 carbons - cmcbtt has 8C tail w/ last carbon fully oxidized to carboxyl group. Will add methyl ester form for current version. See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,J. Gobin,CH. Moore,JR. Reeve,DK. Wong,BW. Gibson,MA. Horwitz Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins. Proc. Natl. Acad. Sci. U.S.A. 1995
Term	EC:6.2.1.13 Acetate--CoA ligase (ADP-forming). - IDA	active	njamshidi	2012-10-05
	For carboxymycobactin see PMID: 7761471, also Cole et al text: Tuberculosis and the Tubercle Bacillus - R group length varies from 2-9 carbons - cmcbtt has 8C tail w/ last carbon fully oxidized to carboxyl group. Will add methyl ester form for current version. See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,J. Gobin,CH. Moore,JR. Reeve,DK. Wong,BW. Gibson,MA. Horwitz Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins. Proc. Natl. Acad. Sci. U.S.A. 1995
Term	TBRXN:MCBTS2 mycobactin synthesis - IPI	active	njamshidi	2012-10-05
	See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	EC:6.2.1.13 Acetate--CoA ligase (ADP-forming). - IPI	active	njamshidi	2012-10-05
	See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	TBRXN:MCBTS2 mycobactin synthesis - ISS	active	njamshidi	2012-10-05
	See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	EC:6.2.1.13 Acetate--CoA ligase (ADP-forming). - ISS	active	njamshidi	2012-10-05
	See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Interaction	Regulatory Rv2711	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) LE. Quadri, J. Sello et al. Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin. Chem. Biol. 1998
Interaction	Regulatory Rv2711	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) authors,JJ. De Voss,K. Rutter,BG. Schroeder,CE. Barry Iron acquisition and metabolism by mycobacteria. J. Bacteriol. 1999
Interaction	Regulatory Rv2711	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) GM. Rodriguez, MI. Voskuil et al. ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infect. Immun. 2002
Interaction	RegulatedBy Rv2711	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. GM. Rodriguez, MI. Voskuil et al. ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infect. Immun. 2002