Rv2383c - phenyloxazoline synthase mbtB

Expression: Most Significant Conditions for Rv2383c

Protein Domains

Gene Information
Locus	Rv2383c
Symbol	mbtB
Gene Name	phenyloxazoline synthase mbtB
Location	2671593 - 2675837 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:4245 bp Protein:1415 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	31415
Related Genes	MAP2177c MAV_2009 Mkms_3533 Mmcs_3470 MSMEG_4515 MT2451 MUL_3632 Mvan_3849 nfa7680
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2383c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2383c Transcript 1
MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSLVGRWRRKGIAVDFAT
LAATPTIEAWSQLVSAGTGVAPTAVAAPGDAGLSQEGEPFPLAPMQHAMWVGRHDHQQLG
GVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLPDGTQRIPPAAGSRDFPISVA
DLRHVAPDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGERTRLHVDLDMQAADAMSYR
ILLADLAALYDGREPPALGYTYREYRQAIEAEETLPQPVRDADRDWWAQRIPQLPDPPAL
PTRAGGERDRRRSTRRWHWLDPQTRDALFARARARGITPAMTLAAAFANVLARWSASSRF
LLNLPLFSRQALHPDVDLLVGDFTSSLLLDVDLTGARTAAARAQAVQEALRSAAGHSAYP
GLSVLRDLSRHRGTQVLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQVT
EFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPSALPAAQRAVRA
ALNGRTAAPSTEALHDGFFRQAQQQPDAPAVFASSGDLSYAQLRDQASAVAAALRAAGLR
VGDTVAVLGPKTGEQVAAVLGILAAGGVYLPIGVDQPRDRAERILATGSVNLALVCGPPC
QVRVPVPTLLLADVLAAAPAEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVE
TFIRHFELGAADRWLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDAWARLIDTY
EVTALNFMPGWLDMLLEVGGGRLSSLRAVAVGGDWVRPDLARRLQVQAPSARFAGLGGAT
ETAVHATIFEVQDAANLPPDWASVPYGVPFPNNACRVVADSGDDCPDWVAGELWVSGRGI
ARGYRGRPELTAERFVEHDGRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEI
EAALQRLPGVHAAAATVLPGGSDVLAAAVCVDDAGVTAESIRQQLADLVPAHMIPRHVTL
LDRIPFTDSGKIDRAEVGALLAAEVERSGDRSAPYAAPRTVLQRALRRIVADILGRANDA
VGVHDDFFALGGDSVLATQVVAGIRRWLDSPSLMVADMFAARTIAALAQLLTGREANADR
LELVAEVYLEIANMTSADVMAALDPIEQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAA
AAYRWLAKSLVANDVDTFVVQYPQRADRRSHPAADSIEALALELFEAGDWHLTAPLTLFG
HCMGAIVAFEFARLAERNGVPVRALWASSGQAPSTVAASGPLPTADRDVLADMVDLGGTD
PVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIHAVGGNRDHRISREMLTSWET
HTSGRFTLSHFDGGHFYLNDHLDAVARMVSADVR*

Genomic Sequence

>Rv2383c
GTGGTGCATGCTACGGCGTGCTCGGAGATCATTCGCGCCGAGGTCGCAGAGTTGCTCGGT
GTCCGCGCCGATGCTCTGCACCCCGGCGCCAACCTCGTTGGTCAGGGCCTGGACTCGATC
CGGATGATGTCGCTGGTGGGGCGCTGGCGCCGGAAGGGCATCGCCGTCGACTTCGCCACA
CTGGCCGCCACACCCACAATCGAGGCCTGGTCCCAACTGGTGTCCGCCGGCACCGGCGTC
GCGCCCACGGCAGTTGCCGCACCAGGGGATGCCGGGTTATCCCAGGAAGGCGAGCCTTTC
CCGCTGGCGCCGATGCAGCACGCGATGTGGGTCGGCCGCCACGACCACCAACAGCTCGGC
GGGGTAGCTGGGCACCTCTACGTCGAGTTCGATGGTGCCCGGGTCGATCCGGACAGGCTC
CGCGCGGCGGCCACCCGGTTGGCGCTGCGGCACCCGATGCTGCGGGTGCAGTTCTTGCCC
GACGGCACCCAGCGCATCCCGCCGGCGGCGGGATCTCGCGACTTTCCCATCAGTGTTGCC
GACCTGCGTCACGTGGCCCCGGATGTCGTCGATCAGCGGTTGGCGGGGATCCGCGACGCC
AAATCGCACCAGCAGCTCGACGGTGCGGTATTCGAACTTGCGTTGACGTTATTACCGGGG
GAGCGCACCCGCCTACATGTCGACCTGGACATGCAGGCCGCTGACGCGATGAGCTACCGC
ATCTTGCTGGCCGACCTGGCGGCCCTCTATGACGGCCGTGAACCGCCGGCACTGGGCTAC
ACCTACCGGGAATACCGGCAGGCTATCGAGGCGGAGGAGACGCTGCCCCAACCGGTTCGC
GACGCCGACCGGGACTGGTGGGCGCAGCGCATCCCGCAGCTGCCGGATCCGCCCGCGCTG
CCTACCCGGGCCGGCGGCGAACGCGACCGGCGCCGCAGCACCCGGCGCTGGCACTGGCTA
GACCCGCAGACCCGCGACGCGTTGTTCGCCCGAGCCCGGGCCCGCGGCATCACCCCGGCG
ATGACGCTGGCCGCGGCCTTTGCCAACGTGCTGGCGCGTTGGTCAGCGTCGTCGCGGTTC
CTGCTGAACCTGCCGTTGTTCAGTCGCCAGGCCCTGCATCCAGACGTCGACCTGCTGGTC
GGTGACTTCACCTCCTCGCTGTTGCTCGACGTCGATCTGACCGGTGCGCGCACGGCGGCG
GCGCGGGCGCAGGCGGTGCAGGAAGCCCTGCGCAGCGCCGCAGGCCACAGTGCATACCCC
GGGCTGTCTGTGCTGCGTGACCTCAGCCGCCACCGTGGCACCCAGGTGCTGGCACCGGTG
GTATTCACCAGCGCGCTGGGGCTCGGCGACCTTTTCTGCCCGGACGTCACCGAGCAATTC
GGCACACCCGGATGGATCATTTCGCAGGGGCCCCAGGTGCTGCTCGACGCCCAGGTCACC
GAGTTCGACGGCGGTGTGCTGGTGAACTGGGATGTCCGCGAGGGGGTCTTTGCACCCGGC
GTCATCGACGCCATGTTCACCCACCAGGTCGACGAATTGCTCCGGTTGGCCGCCGGGGAC
GACGCCTGGGATGCGCCGAGCCCGTCCGCGCTACCCGCCGCGCAACGCGCGGTGCGCGCG
GCGCTGAACGGTCGCACCGCCGCCCCCAGCACCGAGGCGCTGCACGACGGGTTTTTCCGC
CAGGCCCAACAGCAGCCCGACGCGCCGGCGGTGTTCGCCAGTTCCGGCGACTTGAGCTAC
GCCCAACTGCGCGACCAGGCATCGGCGGTGGCCGCGGCGCTGCGTGCTGCGGGCCTACGA
GTCGGCGACACCGTCGCGGTGCTGGGTCCGAAAACGGGCGAACAAGTGGCGGCTGTGCTG
GGGATTTTGGCCGCCGGCGGGGTCTATCTGCCGATCGGCGTCGACCAGCCCCGCGACCGC
GCGGAGCGCATCCTGGCGACCGGTTCGGTCAACTTAGCGCTCGTTTGCGGCCCGCCATGC
CAAGTGCGGGTGCCGGTCCCGACGCTGTTGCTGGCTGACGTGCTTGCCGCCGCGCCGGCA
GAATTCGTGCCCGGGCCTAGCGATCCCACCGCGCTCGCCTATGTGTTGTTCACCTCGGGC
TCAACCGGGGAACCCAAGGGTGTCGAGGTGGCGCACGACGCCGCGATGAACACCGTGGAG
ACCTTCATCCGGCACTTCGAGCTAGGCGCCGCAGATCGCTGGCTTGCCCTGGCGACGCTG
GAGTGCGACATGTCGGTGCTGGACATCTTCGCCGCCCTGCGCTCCGGCGGAGCGATCGTG
GTGGTCGACGAAGCGCAGCGCCGCGATCCCGACGCCTGGGCCCGGCTTATCGACACTTAC
GAGGTCACGGCGTTGAATTTCATGCCGGGCTGGTTGGACATGCTGCTCGAAGTCGGCGGG
GGCCGGCTGTCGTCGCTGCGAGCGGTGGCCGTCGGCGGCGACTGGGTGCGTCCCGACCTG
GCCCGCCGCCTGCAGGTGCAAGCGCCGAGCGCACGGTTCGCGGGGTTGGGTGGAGCCACC
GAAACCGCGGTCCACGCAACCATTTTCGAGGTCCAGGACGCGGCCAATCTGCCACCGGAC
TGGGCCTCGGTGCCATACGGCGTCCCGTTTCCCAACAACGCCTGCCGGGTAGTGGCCGAC
AGCGGCGACGACTGCCCCGATTGGGTGGCCGGTGAGTTGTGGGTGTCCGGTCGCGGAATC
GCCCGGGGTTACCGTGGCCGTCCCGAGCTGACCGCGGAGCGCTTCGTCGAGCATGACGGC
CGCACCTGGTATCGCACCGGTGATCTGGCCCGCTACTGGCACGACGGCACCCTGGAGTTC
GTCGGCCGTGCCGATCACCGCGTCAAGATCAGCGGGTACCGCGTCGAACTCGGCGAGATC
GAAGCCGCGCTGCAGCGCTTGCCCGGTGTGCACGCGGCGGCGGCCACCGTGCTTCCTGGC
GGGTCCGATGTGCTGGCCGCGGCGGTCTGCGTCGACGATGCCGGCGTGACCGCGGAGTCG
ATTCGACAGCAGCTCGCCGATCTGGTGCCCGCGCACATGATTCCGCGCCACGTCACGCTG
CTAGACCGCATCCCCTTTACCGACAGCGGCAAGATCGACCGCGCGGAGGTTGGCGCCCTG
CTTGCCGCCGAGGTCGAGCGGTCTGGCGACAGATCGGCACCCTATGCGGCGCCGCGAACG
GTGCTTCAGCGGGCACTGCGCCGCATCGTCGCGGACATCCTGGGCCGTGCCAACGATGCC
GTGGGCGTGCACGACGACTTCTTTGCCCTGGGCGGCGATTCCGTGCTTGCGACCCAGGTC
GTCGCCGGTATCCGGCGGTGGCTGGATTCGCCGAGCCTGATGGTCGCCGACATGTTTGCC
GCCAGGACCATTGCCGCGTTGGCCCAGTTGCTCACCGGTCGGGAAGCCAACGCCGACCGA
CTCGAACTGGTCGCCGAGGTGTACTTAGAAATCGCGAATATGACAAGTGCCGACGTGATG
GCGGCGCTCGATCCGATCGAGCAGCCCGCACAGCCAGCCTTCAAACCGTGGGTGAAGCGG
TTCACCGGTACTGACAAGCCCGGCGCGGTGCTGGTGTTTCCACACGCCGGCGGCGCTGCC
GCGGCTTACCGGTGGTTGGCAAAATCGTTAGTGGCCAACGACGTTGACACGTTCGTGGTG
CAGTACCCGCAGCGGGCTGACCGGCGCAGCCACCCGGCGGCAGACAGCATCGAGGCGCTG
GCGCTCGAGCTGTTCGAGGCGGGCGACTGGCACCTGACGGCTCCGCTGACGCTGTTCGGC
CATTGCATGGGTGCGATAGTGGCCTTCGAGTTCGCTCGCCTCGCCGAGCGCAATGGCGTG
CCGGTACGTGCACTGTGGGCTTCCTCCGGTCAGGCTCCGTCGACGGTGGCCGCGTCCGGA
CCGTTGCCGACCGCCGACCGTGACGTCCTGGCCGACATGGTGGATCTTGGCGGCACCGAT
CCCGTGCTGCTCGAGGACGAGGAATTCGTTGAACTGCTGGTGCCGGCGGTCAAGGCCGAC
TATCGGGCCCTCAGCGGCTATTCATGTCCACCCGACGTGCGCATCCGCGCCAACATCCAC
GCGGTCGGCGGCAACCGCGACCACCGCATCAGCCGGGAGATGTTGACCAGTTGGGAGACT
CACACCTCCGGTCGCTTCACGCTGTCGCACTTTGATGGTGGTCACTTCTATCTCAACGAT
CACCTCGACGCCGTGGCCCGGATGGTGAGTGCCGATGTCCGATAA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:MCBTS3 carboxymycobactin synthesis - IDA	active	njamshidi	2012-10-05
	For carboxymycobactin see PMID: 7761471, also Cole et al text: Tuberculosis and the Tubercle Bacillus - R group length varies from 2-9 carbons - cmcbtt has 8C tail w/ last carbon fully oxidized to carboxyl group. Will add methyl ester form for current version. See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	EC:6.2.1.13 Acetate--CoA ligase (ADP-forming). - IDA	active	njamshidi	2012-10-05
	For carboxymycobactin see PMID: 7761471, also Cole et al text: Tuberculosis and the Tubercle Bacillus - R group length varies from 2-9 carbons - cmcbtt has 8C tail w/ last carbon fully oxidized to carboxyl group. Will add methyl ester form for current version. See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	TBRXN:MCBTS3 carboxymycobactin synthesis - IDA	active	njamshidi	2012-10-05
	For carboxymycobactin see PMID: 7761471, also Cole et al text: Tuberculosis and the Tubercle Bacillus - R group length varies from 2-9 carbons - cmcbtt has 8C tail w/ last carbon fully oxidized to carboxyl group. Will add methyl ester form for current version. See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,J. Gobin,CH. Moore,JR. Reeve,DK. Wong,BW. Gibson,MA. Horwitz Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins. Proc. Natl. Acad. Sci. U.S.A. 1995
Term	EC:6.2.1.13 Acetate--CoA ligase (ADP-forming). - IDA	active	njamshidi	2012-10-05
	For carboxymycobactin see PMID: 7761471, also Cole et al text: Tuberculosis and the Tubercle Bacillus - R group length varies from 2-9 carbons - cmcbtt has 8C tail w/ last carbon fully oxidized to carboxyl group. Will add methyl ester form for current version. See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,J. Gobin,CH. Moore,JR. Reeve,DK. Wong,BW. Gibson,MA. Horwitz Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins. Proc. Natl. Acad. Sci. U.S.A. 1995
Term	TBRXN:MCBTS2 mycobactin synthesis - IPI	active	njamshidi	2012-10-05
	See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	EC:6.2.1.13 Acetate--CoA ligase (ADP-forming). - IPI	active	njamshidi	2012-10-05
	See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	TBRXN:MCBTS2 mycobactin synthesis - ISS	active	njamshidi	2012-10-05
	See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	EC:6.2.1.13 Acetate--CoA ligase (ADP-forming). - ISS	active	njamshidi	2012-10-05
	See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Interaction	Regulatory Rv2711	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) GM. Rodriguez & I. Smith Mechanisms of iron regulation in mycobacteria: role in physiology and virulence. Mol. Microbiol. 2003
Interaction	Regulatory Rv2711	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) LE. Quadri, J. Sello et al. Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin. Chem. Biol. 1998
Interaction	Regulatory Rv2711	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) authors,JJ. De Voss,K. Rutter,BG. Schroeder,CE. Barry Iron acquisition and metabolism by mycobacteria. J. Bacteriol. 1999
Interaction	Regulatory Rv2711	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) GM. Rodriguez, MI. Voskuil et al. ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infect. Immun. 2002
Interaction	RegulatedBy Rv2711	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Other	EC:	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,JJ. De Voss,K. Rutter,BG. Schroeder,CE. Barry Iron acquisition and metabolism by mycobacteria. J. Bacteriol. 1999