Rv2393 - conserved hypothetical protein

Expression: Most Significant Conditions for Rv2393

Protein Domains

Gene Information
Locus	Rv2393
Symbol
Gene Name	conserved hypothetical protein
Location	2687128 - 2687973 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:846 bp Protein:282 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	28235
Related Genes	Acel_1615 CE2639 cg3113 jk0248 Mkms_3539 Mmcs_3476 MSMEG_4529 MT2463 MUL_3654 Mvan_3859 nfa14150 PPA1066 SAV2137
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2393
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2393 Transcript 1
MTAPATMQSAAMLRSGAIEAPPATMQSAAMRWGHLPLAEESGTIAPQLVLTAHGSKDPRS
AANARAIAGRLARMRPGLDVRVAFCELNSPNLVDVLNRCRGAAVVTPLLLADAYHARVDI
PAQIASCRVGHRVRQASVLGEDIRLVSALHERLTELGVSPFDHTLGVVVLAIGSSHPAAN
ARTSTVASRLAEGTQWAAVTTAFITRPEASLADATDRLRRHGARRMVIAPWLLAPGILSD
RVRGYAREAGIAMAQPLGAHPMVAATMWDRYRQAVAGRIAA*

Genomic Sequence

>Rv2393
GTGACCGCGCCGGCGACGATGCAGAGCGCAGCGATGCTGAGGAGCGGCGCCATCGAAGCA
CCGCCGGCGACGATGCAGAGCGCAGCGATGCGGTGGGGGCACCTCCCGCTTGCGGAGGAG
AGCGGCACCATCGCGCCTCAGCTCGTCCTCACCGCACACGGCAGCAAAGATCCGCGATCG
GCCGCCAACGCACGGGCTATCGCGGGCCGGCTGGCGCGCATGCGGCCCGGGCTCGACGTG
CGGGTCGCGTTCTGTGAGCTCAACTCGCCCAACCTGGTCGACGTGCTCAACCGCTGTCGA
GGAGCAGCTGTGGTCACCCCGCTGCTGCTGGCCGATGCCTACCATGCTCGCGTCGACATC
CCTGCCCAGATCGCCAGCTGCCGCGTTGGTCACCGGGTACGCCAGGCCAGTGTGCTGGGT
GAGGACATTCGGCTGGTGTCAGCGCTGCATGAGCGCCTCACCGAGCTGGGGGTTTCGCCG
TTCGACCACACACTGGGGGTGGTCGTGCTCGCGATCGGCTCATCGCATCCCGCGGCCAAT
GCGCGCACCTCGACGGTGGCGTCAAGGCTGGCGGAGGGGACCCAGTGGGCCGCGGTGACG
ACCGCTTTCATCACCCGACCGGAGGCTTCGCTGGCCGATGCCACCGATCGGTTGCGACGC
CACGGTGCCCGTCGGATGGTCATCGCGCCATGGCTGCTCGCCCCTGGGATACTGTCTGAC
CGGGTACGCGGATACGCACGGGAAGCCGGCATCGCGATGGCACAACCGCTGGGTGCACAC
CCGATGGTGGCCGCGACCATGTGGGATCGCTACCGACAAGCCGTGGCCGGTCGGATCGCG
GCCTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
Interaction	RegulatedBy Rv0485	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique. RM. Goldstone, SD. Goonesekera et al. The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence. Infect. Immun. 2009
Interaction	RegulatedBy Rv0485	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique. RM. Goldstone, SD. Goonesekera et al. The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence. Infect. Immun. 2009
Interaction	RegulatedBy Rv0981	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Symbol	cbiX1	active	mwilliams	2012-03-16
	Reported to be involved in Sulfite reduction R. Pinto, JS. Harrison et al. Sulfite reduction in mycobacteria. J. Bacteriol. 2007