Rv2497c - pyruvate dehydrogenase E1 component alpha subunit pdhA

Expression: Most Significant Conditions for Rv2497c

Protein Domains

Gene Information
Locus	Rv2497c
Symbol	pdhA
Gene Name	pyruvate dehydrogenase E1 component alpha subunit pdhA
Location	2810993 - 2812096 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1104 bp Protein:368 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	29896
Related Genes	MAP2308c MAP2309c MAV_1675 MAV_1676 Mkms_3698 Mkms_3699 Mmcs_3625 Mmcs_3626 MSMEG_4711 MSMEG_4712 MT2571 MT2572 MUL_3774 MUL_3775 Mvan_4085 Mvan_4086 Rv2496c SAV4363
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2497c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2497c Transcript 1
MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAERRYHRDLPEETLRWLYEMMVVTRELDTE
FVNLQRQGELALYTPCRGQEAAQVGAAACLRKTDWLFPQYRELGVYLVRGIPPGHVGVAW
RGTWHGGLQFTTKCCAPMSVPIGTQTLHAVGAAMAAQRLDEDSVTVAFLGDGATSEGDVH
EALNFAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACY
AVMAEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPIPRYRTYL
QDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPDFDVDEVFTTVYAEITPGLQAQREQLR
AELARTD*

Genomic Sequence

>Rv2497c
ATGGGGGAGGGTTCTCGGAGGCCATCTGGGATGTTGATGTCTGTCGATCTTGAGCCGGTG
CAACTCGTCGGCCCGGACGGTACGCCGACGGCCGAACGCCGCTACCACCGTGACCTTCCT
GAGGAAACGCTGCGTTGGCTCTACGAGATGATGGTGGTCACCCGCGAGCTGGATACCGAA
TTCGTCAATCTGCAGCGCCAGGGGGAGCTGGCGTTGTACACGCCCTGTCGCGGGCAGGAA
GCCGCGCAGGTGGGTGCGGCGGCTTGCCTACGCAAAACCGACTGGTTGTTCCCCCAATAC
CGAGAATTGGGCGTCTACCTAGTGCGTGGCATCCCGCCTGGACATGTTGGGGTCGCGTGG
CGTGGAACCTGGCACGGCGGGCTGCAATTCACCACGAAGTGCTGTGCACCGATGTCGGTT
CCCATCGGCACCCAGACCTTGCACGCGGTGGGCGCGGCGATGGCCGCGCAACGCCTGGAC
GAGGACTCCGTGACGGTGGCCTTTCTGGGCGACGGCGCCACCAGCGAGGGCGACGTACAT
GAGGCGCTCAATTTCGCGGCGGTGTTCACCACACCGTGCGTGTTCTACGTGCAGAACAAC
CAGTGGGCAATCTCGATGCCGGTATCCAGGCAGACCGCCGCACCATCTATCGCGCACAAG
GCGATTGGCTACGGGATGCCAGGCATCCGGGTGGACGGCAACGACGTGCTGGCATGCTAT
GCGGTGATGGCCGAAGCTGCCGCTCGGGCTCGGGCCGGCGACGGTCCAACGCTGATCGAG
GCGGTCACTTACCGTCTTGGTCCGCACACCACCGCCGATGATCCAACCCGGTACCGCAGC
CAGGAGGAGGTGGACCGCTGGGCGACGCTGGACCCGATTCCGCGCTATCGCACTTACTTA
CAAGATCAGGGCCTGTGGTCGCAACGCCTCGAGGAACAGGTGACGGCTCGGGCAAAACAC
GTGCGGTCCGAGCTACGCGACGCGGTCTTTGATGCGCCTGACTTCGACGTCGATGAGGTG
TTCACCACGGTGTACGCCGAAATCACACCCGGGTTGCAGGCGCAGCGCGAACAGCTGCGT
GCCGAACTGGCGCGGACTGACTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Operon Rv2496c	active	akankshajain.21	2012-10-05
	Coexpression J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
Interaction	Operon Rv2495c	active	akankshajain.21	2012-10-05
	Coexpression J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
Interaction	Operon Rv2496c	active	akankshajain.21	2012-10-05
	Coexpression J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
Interaction	Operon Rv2495c	active	akankshajain.21	2012-10-05
	Coexpression J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
Interaction	RegulatedBy Rv0348	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Interaction	RegulatedBy Rv0182c	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. JH. Lee, DE. Geiman et al. Role of stress response sigma factor SigG in Mycobacterium tuberculosis. J. Bacteriol. 2008
Term	EC:1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring). - NR	active	extern:JZUCKER	2012-03-06
	Inferred from mutant phenotype authors,A. Venugopal,R. Bryk,S. Shi,K. Rhee,P. Rath,D. Schnappinger,S. Ehrt,C. Nathan Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell Host Microbe 2011
Term	EC:1.2.4.1 Pyruvate dehydrogenase (acetyl-transferring). - NR	active	extern:JZUCKER	2012-03-06
	Inferred from mutant phenotype authors,A. Venugopal,R. Bryk,S. Shi,K. Rhee,P. Rath,D. Schnappinger,S. Ehrt,C. Nathan Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell Host Microbe 2011
Term	EC:1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring). - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
Term	EC:1.2.4.1 Pyruvate dehydrogenase (acetyl-transferring). - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011