Rv2524c - fatty-acid synthase fas
Protein Domains

Gene Information
LocusRv2524c
Symbolfas
Gene Namefatty-acid synthase fas
Location2840123 - 2849332 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:9210 bp
Protein:3070 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number37865
Related GenesCE2392 cg2743 DIP1846 MAP2332c MAV_1650 Mkms_3721 ML1191 Mmcs_3648 MSMEG_4757 MT2600 MUL_3818 Mvan_4125 nfa12570
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
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Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
TermTBRXN:FAS140 fatty acid synthase (n-C14:0) - IDAactivenjamshidi2012-10-05
mtFABH (Rv0533c) - link between FAS I and FAS II - highest affinity for C12:0, see PMID: 10840036 (since FA synthesis is lumped, does not extend immediately to FAS II).
KH. Choi, L. Kremer et al. Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. J. Biol. Chem. 2000
TermEC:2.3.1.85 Fatty-acid synthase. - IDAactivenjamshidi2012-10-05
mtFABH (Rv0533c) - link between FAS I and FAS II - highest affinity for C12:0, see PMID: 10840036 (since FA synthesis is lumped, does not extend immediately to FAS II).
KH. Choi, L. Kremer et al. Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. J. Biol. Chem. 2000
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
InteractionRegulatedBy Rv3911activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
S. Raman, X. Puyang et al. Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis. J. Bacteriol. 2006
InteractionRegulatedBy Rv0757activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
InteractionRegulatedBy Rv1221activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
NameFatty acid synthetase type Iactivemjackson2012-10-05
FAS-I
NameFatty acid synthetase type Iactivemjackson2012-10-05
FAS-I
TermEC:2.3.1.86 Fatty-acyl-CoA synthase. - NRactiveextern:JZUCKER2012-03-06
Assay of protein purified to homogeneity from a heterlogous host
authors,DE. Vance,O. Mitsuhashi,K. Bloch Purification and properties of the fatty acid synthetase from Mycobacterium phlei. J. Biol. Chem. 1973
TermEC:2.3.1.- Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. - NRactiveextern:JZUCKER2012-03-06
Assay of protein purified to homogeneity from a heterlogous host
authors,DE. Vance,O. Mitsuhashi,K. Bloch Purification and properties of the fatty acid synthetase from Mycobacterium phlei. J. Biol. Chem. 1973
TermEC:4.2.1.- Lyases. Carbon-oxygen lyases. Hydro-lyases. - NRactiveextern:JZUCKER2012-03-06
Assay of protein purified to homogeneity from a heterlogous host
authors,DE. Vance,O. Mitsuhashi,K. Bloch Purification and properties of the fatty acid synthetase from Mycobacterium phlei. J. Biol. Chem. 1973
TermEC:4.2.1.61 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase. - NRactiveextern:JZUCKER2012-03-06
Assay of protein purified to homogeneity from a heterlogous host
authors,DE. Vance,O. Mitsuhashi,K. Bloch Purification and properties of the fatty acid synthetase from Mycobacterium phlei. J. Biol. Chem. 1973
TermEC:4.2.1.59 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase. - NRactiveextern:JZUCKER2012-03-06
Assay of protein purified to homogeneity from a heterlogous host
authors,DE. Vance,O. Mitsuhashi,K. Bloch Purification and properties of the fatty acid synthetase from Mycobacterium phlei. J. Biol. Chem. 1973
TermEC:4.2.1.58 Crotonoyl-[acyl-carrier-protein] hydratase. - NRactiveextern:JZUCKER2012-03-06
Assay of protein purified to homogeneity from a heterlogous host
authors,DE. Vance,O. Mitsuhashi,K. Bloch Purification and properties of the fatty acid synthetase from Mycobacterium phlei. J. Biol. Chem. 1973
TermEC:1.3.1.9 Enoyl-[acyl-carrier-protein] reductase (NADH). - NRactiveextern:JZUCKER2012-03-06
Assay of protein purified to homogeneity from a heterlogous host
authors,DE. Vance,O. Mitsuhashi,K. Bloch Purification and properties of the fatty acid synthetase from Mycobacterium phlei. J. Biol. Chem. 1973
TermEC:1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase. - NRactiveextern:JZUCKER2012-03-06
Assay of protein purified to homogeneity from a heterlogous host
authors,DE. Vance,O. Mitsuhashi,K. Bloch Purification and properties of the fatty acid synthetase from Mycobacterium phlei. J. Biol. Chem. 1973
TermEC:2.3.1.41 Beta-ketoacyl-acyl-carrier-protein synthase I. - NRactiveextern:JZUCKER2012-03-06
Assay of protein purified to homogeneity from a heterlogous host
authors,DE. Vance,O. Mitsuhashi,K. Bloch Purification and properties of the fatty acid synthetase from Mycobacterium phlei. J. Biol. Chem. 1973
TermEC:2.3.1.38 [Acyl-carrier-protein] S-acetyltransferase. - NRactiveextern:JZUCKER2012-03-06
Assay of protein purified to homogeneity from a heterlogous host
authors,DE. Vance,O. Mitsuhashi,K. Bloch Purification and properties of the fatty acid synthetase from Mycobacterium phlei. J. Biol. Chem. 1973
TermEC:1.3.1.10 Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific). - NRactivejjmcfadden2012-03-05
Inferred from direct assay
ND. Fernandes & PE. Kolattukudy Cloning, sequencing and characterization of a fatty acid synthase-encoding gene from Mycobacterium tuberculosis var. bovis BCG. Gene 1996
TermEC:1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
ND. Fernandes & PE. Kolattukudy Cloning, sequencing and characterization of a fatty acid synthase-encoding gene from Mycobacterium tuberculosis var. bovis BCG. Gene 1996
TermEC:2.3.1.41 Beta-ketoacyl-acyl-carrier-protein synthase I. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
ND. Fernandes & PE. Kolattukudy Cloning, sequencing and characterization of a fatty acid synthase-encoding gene from Mycobacterium tuberculosis var. bovis BCG. Gene 1996
TermEC:1.3.1.11 2-coumarate reductase. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
ND. Fernandes & PE. Kolattukudy Cloning, sequencing and characterization of a fatty acid synthase-encoding gene from Mycobacterium tuberculosis var. bovis BCG. Gene 1996
TermEC:2.3.1.- Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
ND. Fernandes & PE. Kolattukudy Cloning, sequencing and characterization of a fatty acid synthase-encoding gene from Mycobacterium tuberculosis var. bovis BCG. Gene 1996