Rv2593c - holliday junction DNA helicase ruvA

Expression: Most Significant Conditions for Rv2593c

Protein Domains

Gene Information
Locus	Rv2593c
Symbol	ruvA
Gene Name	holliday junction DNA helicase ruvA
Location	2924230 - 2924820 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:591 bp Protein:197 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	713
Related Genes	Acel_1344 BL0728 CE1774 cg1870 DIP1376 jk1055 MAP1037 MAV_3474 Mkms_2313 ML0482 Mmcs_2266 MSMEG_2944 MT2670 MUL_1715 Mvan_2574 nfa36960 PPA1159 SAV6834
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2593c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2593c Transcript 1
MIASVRGEVLEVALDHVVIEAAGVGYRVNATPATLATLRQGTEARLITAMIVREDSMTLY
GFPDGETRDLFLTLLSVSGVGPRLAMAALAVHDAPALRQVLADGNVAALTRVPGIGKRGA
ERMVLELRDKVGVAATGGALSTNGHAVRSPVVEALVGLGFAAKQAEEATDTVLAANHDAT
TSSALRSALSLLGKAR*

Genomic Sequence

>Rv2593c
ATGATCGCCTCGGTCCGCGGTGAGGTGCTCGAGGTGGCGCTTGACCATGTGGTGATCGAG
GCCGCCGGTGTGGGCTACCGAGTGAACGCGACACCGGCGACGCTGGCGACGTTGCGGCAA
GGCACCGAGGCCCGGCTGATCACCGCGATGATTGTGCGCGAGGACTCGATGACGCTGTAC
GGGTTTCCCGACGGGGAAACCCGCGACCTATTCCTGACGCTGCTGTCGGTCTCCGGCGTT
GGGCCCCGGCTGGCGATGGCGGCACTGGCCGTGCACGACGCTCCGGCGCTACGGCAGGTG
CTGGCCGACGGCAACGTCGCCGCCCTGACCCGGGTGCCTGGGATCGGCAAGCGGGGCGCC
GAACGCATGGTGTTGGAACTACGCGACAAGGTTGGGGTGGCAGCCACCGGCGGCGCACTC
TCGACCAACGGCCACGCGGTGCGCAGTCCCGTGGTCGAGGCTCTGGTCGGCCTGGGCTTT
GCGGCCAAACAGGCCGAGGAGGCCACCGATACGGTGCTGGCCGCCAACCATGACGCGACG
ACATCCAGCGCGCTGCGGTCTGCCTTGTCGTTGCTGGGGAAGGCCCGATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv2973c	active	shahanup86	2012-10-05
	Structural Analysis D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003
Interaction	PhysicalInteraction Rv2973c	active	shahanup86	2012-10-05
	Structural Analysis authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000
Interaction	PhysicalInteraction Rv2973c	active	shahanup86	2012-10-05
	Structural Analysis authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004
Interaction	PhysicalInteraction Rv2973c	active	shahanup86	2012-10-05
	Structural Analysis authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002
Interaction	PhysicalInteraction Rv2973c	active	shahanup86	2012-10-05
	Structural Analysis authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001
Interaction	PhysicalInteraction Rv2973c	active	shahanup86	2012-10-05
	Structural Analysis authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999
Interaction	PhysicalInteraction Rv2973c	active	shahanup86	2012-10-05
	Spectrophotometric D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003
Interaction	PhysicalInteraction Rv2973c	active	shahanup86	2012-10-05
	Spectrophotometric authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000
Interaction	PhysicalInteraction Rv2973c	active	shahanup86	2012-10-05
	Spectrophotometric authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004
Interaction	PhysicalInteraction Rv2973c	active	shahanup86	2012-10-05
	Spectrophotometric authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002
Interaction	PhysicalInteraction Rv2973c	active	shahanup86	2012-10-05
	Spectrophotometric authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001
Interaction	PhysicalInteraction Rv2973c	active	shahanup86	2012-10-05
	Spectrophotometric authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999
Interaction	PhysicalInteraction Rv2603c	active	sureshks89	2012-10-05
	authors,MY. Galperin,EV. Koonin From complete genome sequence to 'complete' understanding? Trends Biotechnol. 2010
Interaction	PhysicalInteraction Rv2603c	active	sureshks89	2012-10-05
	authors,H. Liang,L. Li,Z. Dong,MG. Surette,K. Duan The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. J. Bacteriol. 2008
Interaction	PhysicalInteraction Rv2594c	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) PC. Brooks, F. Movahedzadeh et al. Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. J. Bacteriol. 2001
Interaction	PhysicalInteraction Rv2594c	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) JR. Prabu, S. Thamotharan et al. Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006
Interaction	PhysicalInteraction Rv2594c	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) PC. Brooks, F. Movahedzadeh et al. Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. J. Bacteriol. 2001
Interaction	PhysicalInteraction Rv2594c	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) JR. Prabu, S. Thamotharan et al. Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006
Interaction	PhysicalInteraction Rv2594c	active	shahanup86	2012-10-05
	Structural Analysis authors,CV. Privezentzev,A. Keeley,B. Sigala,IR. Tsaneva The role of RuvA octamerization for RuvAB function in vitro and in vivo. J. Biol. Chem. 2005
Interaction	PhysicalInteraction Rv2592c	active	shahanup86	2012-10-05
	Structural Analysis authors,CV. Privezentzev,A. Keeley,B. Sigala,IR. Tsaneva The role of RuvA octamerization for RuvAB function in vitro and in vivo. J. Biol. Chem. 2005
Interaction	PhysicalInteraction Rv2594c	active	shahanup86	2012-10-05
	Structural Analysis JS. Khanduja, P. Tripathi et al. Mycobacterium tuberculosis RuvA Induces Two Distinct Types of Structural Distortions between the Homologous and Heterologous Holliday Junctions (dagger). Biochemistry 2008
Interaction	PhysicalInteraction Rv2592c	active	shahanup86	2012-10-05
	Structural Analysis JS. Khanduja, P. Tripathi et al. Mycobacterium tuberculosis RuvA Induces Two Distinct Types of Structural Distortions between the Homologous and Heterologous Holliday Junctions (dagger). Biochemistry 2008
Interaction	PhysicalInteraction Rv2594c	active	shahanup86	2012-10-05
	Structural Analysis JR. Prabu, S. Thamotharan et al. Crystallographic and modelling studies on Mycobacterium tuberculosis RuvA Additional role of RuvB-binding domain and inter species variability. Biochim. Biophys. Acta 2009
Interaction	PhysicalInteraction Rv2592c	active	shahanup86	2012-10-05
	Structural Analysis JR. Prabu, S. Thamotharan et al. Crystallographic and modelling studies on Mycobacterium tuberculosis RuvA Additional role of RuvB-binding domain and inter species variability. Biochim. Biophys. Acta 2009
Interaction	PhysicalInteraction Rv2594c	active	shahanup86	2012-10-05
	Structural Analysis PC. Brooks, F. Movahedzadeh et al. Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. J. Bacteriol. 2001
Interaction	PhysicalInteraction Rv2592c	active	shahanup86	2012-10-05
	Structural Analysis PC. Brooks, F. Movahedzadeh et al. Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. J. Bacteriol. 2001
Interaction	PhysicalInteraction Rv2594c	active	shahanup86	2012-10-05
	Structural Analysis JR. Prabu, S. Thamotharan et al. Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006
Interaction	PhysicalInteraction Rv2592c	active	shahanup86	2012-10-05
	Structural Analysis JR. Prabu, S. Thamotharan et al. Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006
Interaction	PhysicalInteraction Rv2592c	active	shahanup86	2012-10-05
	Structural Analysis authors,CV. Privezentzev,A. Keeley,B. Sigala,IR. Tsaneva The role of RuvA octamerization for RuvAB function in vitro and in vivo. J. Biol. Chem. 2005
Interaction	PhysicalInteraction Rv2592c	active	shahanup86	2012-10-05
	Structural Analysis JS. Khanduja, P. Tripathi et al. Mycobacterium tuberculosis RuvA Induces Two Distinct Types of Structural Distortions between the Homologous and Heterologous Holliday Junctions (dagger). Biochemistry 2008
Interaction	PhysicalInteraction Rv2592c	active	shahanup86	2012-10-05
	Structural Analysis JR. Prabu, S. Thamotharan et al. Crystallographic and modelling studies on Mycobacterium tuberculosis RuvA Additional role of RuvB-binding domain and inter species variability. Biochim. Biophys. Acta 2009
Interaction	PhysicalInteraction Rv2592c	active	shahanup86	2012-10-05
	Structural Analysis JR. Prabu, S. Thamotharan et al. Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006
Other	TBPWY:Recombination repair	active	vmizrahi	2012-03-05
	Increased expression in Mtb from clinical lung samples
Other	TBPWY:Recombination repair	active	vmizrahi	2012-03-05
	RuvA induces two distinct types of structural distortions between the homologous and heterologous Holliday junctions.
Other	TBPWY:Recombination repair	active	vmizrahi	2012-03-05
	Crystallographic and modelling studies on Mycobacterium tuberculosis RuvA
Other	TBPWY:Recombination repair	active	vmizrahi	2012-03-05
	DNA Replication Fork Reversal Catalyzed by RuvAB Proteins functionally characterized