Rv2763c - dihydrofolate reductase dfrA

Expression: Most Significant Conditions for Rv2763c

Protein Domains

Gene Information
Locus	Rv2763c
Symbol	dfrA
Gene Name	dihydrofolate reductase dfrA
Location	3073130 - 3073609 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:480 bp Protein:160 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	380
Related Genes	BL1666 CE0918 cg0965 DIP0824 jk0440 MAP2868c MAV_3651 Mkms_2159 ML1518 Mmcs_2113 MSMEG_2671 MT2833 MUL_2179 Mvan_2381 nfa50230 PPA1671
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2763c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2763c Transcript 1
MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR
RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP
REAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS*

Genomic Sequence

>Rv2763c
ATGGTGGGGCTGATCTGGGCTCAAGCGACATCGGGTGTCATCGGCCGCGGCGGCGACATC
CCCTGGCGCTTGCCCGAGGACCAGGCGCATTTCCGGGAGATCACCATGGGGCACACGATC
GTGATGGGCCGGCGCACATGGGATTCGCTGCCGGCTAAAGTCCGGCCGCTGCCCGGCCGG
CGAAATGTCGTACTGAGCCGCCAAGCTGACTTTATGGCCAGCGGGGCTGAGGTTGTCGGT
TCACTCGAGGAGGCGCTGACCAGCCCGGAGACGTGGGTGATCGGAGGCGGACAAGTCTAT
GCGCTGGCGCTGCCGTACGCGACCAGATGTGAGGTTACCGAGGTCGACATCGGCCTGCCG
CGCGAAGCCGGTGACGCGCTGGCCCCCGTGCTGGACGAGACATGGCGGGGCGAGACGGGG
GAGTGGCGCTTCAGCCGGTCCGGGTTGCGGTACCGGTTGTACAGCTACCACCGCTCATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Symbol	DHFR	active	jlew	2012-03-07
	interacts with Rv3097c. Using an in vivo pull-down assay, for the first time we have confirmed the presence of three pairs of PE/PPE-related novel protein interactions in this pathogen. J. Zeng, L. Zhang et al. Over-producing soluble protein complex and validating protein-protein interaction through a new bacterial co-expression system. Protein Expr. Purif. 2010
Term	EC:1.5.1.3 Dihydrofolate reductase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay J. Rengarajan, CM. Sassetti et al. The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Mol. Microbiol. 2004