Rv2846c - membrane efflux protein efpA

Expression: Most Significant Conditions for Rv2846c

Protein Domains

Gene Information
Locus	Rv2846c
Symbol	efpA
Gene Name	membrane efflux protein efpA
Location	3153039 - 3154631 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1593 bp Protein:531 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	34462
Related Genes	MAP2915c MAV_3702 Mkms_2121 ML1562 Mmcs_2075 MSMEG_2619 MT2912 MUL_2115 Mvan_2306 Mvan_2307 nfa40760
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2846c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2846c Transcript 1
MTALNDTERAVRNWTAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSRSFIAAVIAIGG
MQLLATMDSTVAIVALPKIQNELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRT
FIVGVALFTISSVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPARNAAT
AVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDA
TGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAENPVVPFHL
FRDRNRLVTFSAILLAGGVMFSLTVCIGLYVQDILGYSALRAGVGFIPFVIAMGIGLGVS
SQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHRGVPYFPNLVMPIVVGGIGIGMAVVPLT
LSAIAGVGFDQIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQL
AALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL*

Genomic Sequence

>Rv2846c
ATGACGGCTCTCAACGACACAGAGCGGGCGGTCCGTAACTGGACAGCCGGACGCCCACAC
CGTCCGGCCCCGATGCGCCCGCCGCGCTCGGAGGAGACCGCTTCAGAGCGCCCCAGCAGG
TACTACCCGACTTGGCTGCCCTCGCGCAGCTTTATCGCTGCGGTTATTGCTATCGGCGGG
ATGCAGCTGCTGGCGACCATGGACAGCACCGTCGCCATCGTCGCGCTACCTAAGATTCAA
AACGAGCTGAGCTTGTCTGATGCCGGCCGCAGCTGGGTGATCACCGCCTACGTGCTGACC
TTCGGCGGGCTGATGCTGCTCGGCGGCCGGCTTGGCGACACCATCGGGCGCAAACGCACC
TTCATTGTTGGCGTTGCGCTATTCACCATCTCGTCGGTGCTGTGCGCGGTCGCCTGGGAC
GAGGCGACGTTGGTGATCGCCCGGTTGTCCCAGGGTGTGGGGTCGGCCATCGCATCTCCG
ACCGGTCTGGCGCTGGTGGCGACCACGTTCCCCAAGGGACCTGCCCGCAACGCCGCGACG
GCGGTGTTCGCCGCGATGACCGCGATCGGGTCGGTGATGGGGCTGGTGGTCGGCGGAGCA
CTGACCGAGGTGTCATGGCGGTGGGCGTTCCTGGTGAACGTGCCGATCGGGCTGGTGATG
ATCTACCTGGCCCGCACCGCCCTACGGGAAACCAACAAAGAACGGATGAAGCTCGACGCC
ACCGGGGCCATACTGGCCACGCTGGCATGCACCGCGGCGGTTTTCGCCTTCTCGATCGGT
CCTGAAAAGGGCTGGATGTCAGGCATTACCATCGGTTCGGGCCTGGTGGCCTTGGCGGCC
GCTGTCGCGTTTGTCATCGTGGAGCGCACTGCCGAGAACCCCGTCGTGCCGTTCCACTTG
TTCCGCGACCGCAACCGGTTGGTCACGTTCAGCGCGATCCTGTTGGCCGGCGGCGTCATG
TTCAGCCTGACCGTCTGCATCGGCCTGTACGTGCAGGACATCTTGGGCTACAGCGCGCTA
CGCGCGGGCGTAGGTTTCATCCCGTTCGTCATCGCGATGGGAATCGGCCTAGGTGTGTCC
TCGCAGCTGGTGTCCCGGTTTTCGCCACGGGTGTTGACCATCGGCGGCGGATATCTGCTA
TTCGGCGCCATGCTGTACGGCTCATTTTTCATGCACCGTGGTGTGCCCTACTTCCCCAAC
CTGGTCATGCCGATCGTCGTCGGCGGGATTGGCATCGGCATGGCCGTCGTCCCGCTGACT
CTGTCGGCGATCGCTGGCGTCGGCTTCGACCAGATCGGTCCGGTATCGGCAATTGCGCTG
ATGCTGCAGAGCCTGGGCGGTCCGCTGGTGCTCGCCGTCATCCAGGCTGTGATCACGTCG
CGCACGCTGTACCTGGGCGGTACCACCGGTCCGGTGAAGTTCATGAACGACGTGCAGTTG
GCCGCGCTTGACCACGCCTACACCTACGGCCTGCTGTGGGTGGCCGGAGCGGCCATCATC
GTCGGCGGTATGGCGCTGTTTATCGGGTATACGCCGCAGCAGGTTGCCCATGCGCAGGAG
GTCAAGGAAGCGATCGACGCCGGCGAGCTGTAA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Transcription Rv3597c	active	sourish10	2012-10-05
	Co-expression (Functional linkage) R. Colangeli, D. Helb et al. Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis. PLoS Pathog. 2007
Interaction	RegulatedBy Rv0348	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Interaction	RegulatedBy Rv0981	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006