Rv2914c - transmembrane serine/threonine-protein kinase I pknI

Expression: Most Significant Conditions for Rv2914c

Protein Domains

Gene Information
Locus	Rv2914c
Symbol	pknI
Gene Name	transmembrane serine/threonine-protein kinase I pknI
Location	3221767 - 3223524 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1758 bp Protein:586 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	21015
Related Genes	MT2982 MUL_2042
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2914c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2914c Transcript 1
MALASGVTFAGYTVVRMLGCSAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRE
TEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTA
VAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQPSYPAPELSAGADVD
GRADQYALALTAIHLFAGAPPVDRSHTGPLQPPKLSAFRPDLARLDGVLSRALATAPADR
FGSCREFADAMNEQAGVAIADQSSGGVDASEVTAAAGEEAYVVDYPAYGWPEAVDCKEPS
ARAPAPAAPTPQRRGSMLQSAAGVLARRLDNFSTATKAPASPTRRRPRRILVGAVAVLLL
AGLFAVGIVIGRKTNTTATEVARPPTSGSAVPSAPTTTVAVTAPVPLDGTYRIEIQRSKQ
TYDYTPTPQPPDVNTWWAFRTSCTPTECLAAATMLDDNDHTQAKTPPVRPFLMQFGEGQW
KSRPETVQFPCVGPNGSPSTQATTQLLALRPQPQGDLVGEMVVTVHSNECGQQGAVIRIP
AVASRSGDLPPAVTVPDPATIPDTPDTTSTATLTPPTTTAPGPGR*

Genomic Sequence

>Rv2914c
ATGGCGTTGGCCAGCGGCGTGACCTTTGCCGGCTACACCGTCGTGCGGATGCTGGGTTGT
TCCGCGATGGGTGAGGTCTACCTCGTGCAACATCCCGGATTCCCCGGCTGGCAGGCGCTG
AAGGTGCTTTCGCCGGCGATGGCTGCGGACGACGAATTTCGCCGCCGATTTCAACGGGAG
ACCGAGGTTGCCGCGCGGCTATTTCACCCGCACATCCTGGAGGTTCATGATCGCGGTGAG
TTCGACGGGCAGCTGTGGATTGCGATGGACTACGTCGATGGCATCGACGCCACGCAGCAT
ATGGCCGACCGGTTTCCGGCGGTCTTGCCGGTTGGTGAGGTACTCGCCATCGTCACTGCC
GTAGCCGGAGCTCTCGACTACGCCCACCAGCGCGGCCTGCTGCATCGTGACGTCAACCCC
GCCAACGTCGTGCTAACCAGTCAGAGTGCTGGCGACCAACGGATCCTGTTGGCCGACTTC
GGAATTGCCAGCCAACCCAGCTATCCGGCGCCCGAACTGTCGGCGGGGGCCGACGTTGAC
GGGCGTGCCGATCAGTACGCGTTGGCGCTTACCGCCATACACCTGTTCGCCGGTGCGCCG
CCGGTTGATCGTTCGCACACCGGACCGCTGCAGCCACCGAAGCTCTCCGCCTTCCGCCCG
GACCTGGCACGCCTCGACGGTGTCCTCTCGCGTGCGCTCGCCACAGCGCCCGCGGACCGG
TTCGGCAGCTGCCGCGAGTTCGCCGACGCGATGAACGAACAGGCCGGCGTCGCGATCGCT
GATCAGAGCTCGGGGGGTGTCGACGCTTCTGAGGTCACCGCGGCGGCCGGTGAGGAAGCG
TATGTCGTCGACTACCCGGCTTATGGTTGGCCCGAGGCCGTCGACTGCAAAGAACCATCC
GCCCGGGCACCGGCGCCGGCGGCCCCGACCCCCCAACGGCGCGGCTCGATGCTGCAGTCA
GCGGCCGGGGTGCTGGCGCGCCGCCTGGACAACTTCTCCACCGCCACCAAGGCTCCGGCG
AGCCCCACCAGGCGCCGGCCACGCCGGATCCTGGTCGGTGCGGTAGCGGTGTTGCTATTG
GCTGGCCTGTTCGCGGTCGGCATCGTGATTGGGCGCAAGACGAACACGACCGCCACCGAA
GTCGCGCGCCCGCCGACCAGTGGGTCGGCTGTGCCCAGCGCCCCGACGACCACCGTCGCG
GTCACCGCGCCGGTCCCACTGGACGGCACATACCGCATCGAGATCCAACGCTCAAAGCAG
ACCTACGACTACACCCCTACGCCGCAACCGCCGGACGTGAACACCTGGTGGGCGTTCCGC
ACTTCGTGCACTCCGACCGAATGTCTCGCGGCCGCAACGATGCTCGACGACAACGACCAC
ACCCAGGCCAAGACTCCGCCCGTTAGGCCGTTCCTCATGCAGTTCGGCGAGGGCCAGTGG
AAGTCGCGGCCGGAGACGGTGCAGTTCCCGTGCGTCGGGCCCAACGGCTCGCCGAGTACA
CAGGCCACGACGCAGTTGCTCGCACTGCGACCGCAACCGCAGGGCGACCTCGTCGGCGAA
ATGGTCGTCACTGTGCATAGCAACGAATGTGGACAACAAGGAGCGGTCATTCGGATTCCC
GCGGTGGCCAGCCGCAGTGGTGATCTTCCCCCGGCAGTCACCGTGCCGGACCCAGCAACG
ATTCCTGATACCCCCGATACAACGTCCACAGCCACCCTGACGCCGCCGACCACAACGGCG
CCGGGGCCCGGTCGCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Signaling Rv2916c	active	priti.priety	2012-10-05
	Affinity purification (Physical interaction) A. Singh, Y. Singh et al. Protein kinase I of Mycobacterium tuberculosis: cellular localization and expression during infection of macrophage-like cells. Tuberculosis (Edinburgh, Scotland) 2006
Interaction	Signaling Rv2913c	active	priti.priety	2012-10-05
	Affinity purification (Physical interaction) A. Singh, Y. Singh et al. Protein kinase I of Mycobacterium tuberculosis: cellular localization and expression during infection of macrophage-like cells. Tuberculosis (Edinburgh, Scotland) 2006
Interaction	Signaling Rv2916c	active	priti.priety	2012-10-05
	Affinity purification (Physical interaction) R. Gopalaswamy, S. Narayanan et al. The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection. FEMS Microbiol. Lett. 2009
Interaction	Signaling Rv2913c	active	priti.priety	2012-10-05
	Affinity purification (Physical interaction) R. Gopalaswamy, S. Narayanan et al. The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection. FEMS Microbiol. Lett. 2009
Interaction	Signaling Rv2916c	active	priti.priety	2012-10-05
	Affinity purification (Physical interaction) R. Gopalaswamy, PR. Narayanan et al. Cloning, overexpression, and characterization of a serine/threonine protein kinase pknI from Mycobacterium tuberculosis H37Rv. Protein Expr. Purif. 2004
Interaction	Signaling Rv2913c	active	priti.priety	2012-10-05
	Affinity purification (Physical interaction) R. Gopalaswamy, PR. Narayanan et al. Cloning, overexpression, and characterization of a serine/threonine protein kinase pknI from Mycobacterium tuberculosis H37Rv. Protein Expr. Purif. 2004
Interaction	Operon Rv2913c	active	ashwinigbhat	2012-10-05
	Co-expression (Functional linkage) R. Gopalaswamy, S. Narayanan et al. The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection. FEMS Microbiol. Lett. 2009
Interaction	Operon Rv2913c	active	ashwinigbhat	2012-10-05
	Co-expression (Functional linkage) Y. Av-Gay,M. Everett The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis. Trends Microbiol. 2000
Interaction	Operon Rv2913c	active	ashwinigbhat	2012-10-05
	Co-expression (Functional linkage) authors,A. Zelikovski,J. Abu-Dalu,I. Urca Meso-appendicular testis. Br J Urol 1975
Interaction	Operon Rv2913c	active	ashwinigbhat	2012-10-05
	Co-expression (Functional linkage) authors,BM. Altura Role of prostaglandins and histamine in reactive hyperemia: in-vivo studies on single mesenteric arterioles. Prostaglandins Med 1978