Rv2942 - transmembrane transport protein mmpL7

Expression: Most Significant Conditions for Rv2942

Protein Domains

Gene Information
Locus	Rv2942
Symbol	mmpL7
Gene Name	transmembrane transport protein mmpL7
Location	3285070 - 3287832 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:2763 bp Protein:921 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	22143
Related Genes	Mkms_3174 ML0137 Mmcs_3114 MSMEG_4741 MT3012 MUL_2007
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2942
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2942 Transcript 1
MPSPAGRLHRIRYIRLKKSSPDCRATITSGSADGQRRSPRLTNLLVVAAWVAAAVIANLL
LTFTQAEPHDTSPALLPQDAKTAAATSRIAQAFPGTGSNAIAYLVVEGGSTLEPQDQPYY
DAAVGALRADTRHVGSVLDWWSDPVTAPLGTSPDGRSATAMVWLRGEAGTTQAAESLDAV
RSVLRQLPPSEGLRASIVVPAITNDMPMQITAWQSATIVTVAAVIAVLLLLRARLSVRAA
AIVLLTADLSLAVAWPLAAVVRGHDWGTDSVFSWTLAAVLTIGTITAATMLAARLGSDAG
HSAAPTYRDSLPAFALPGACVAIFTGPLLLARTPALHGVGTAGLGVFVALAASLTVLPAL
IALAGASRQLPAPTTGAGWTGRLSLPVSSASALGTAAVLAICMLPIIGMRWGVAENPTRQ
GGAQVLPGNALPDVVVIKSARDLRDPAALIAINQVSHRLVEVPGVRKVESAAWPAGVPWT
DASLSSAAGRLADQLGQQAGSFVPAVTAIKSMKSIIEQMSGAVDQLDSTVNVTLAGARQA
QQYLDPMLAAARNLKNKTTELSEYLETIHTWIVGFTNCPDDVLCTAMRKVIEPYDIVVTG
MNELSTGADRISAISTQTMSALSSAPRMVAQMRSALAQVRSFVPKLETTIQDAMPQIAQA
SAMLKNLSADFADTGEGGFHLSRKDLADPSYRHVRESMFSSDGTATRLFLYSDGQLDLAA
AARAQQLEIAAGKAMKYGSLVDSQVTVGGAAQIAAAVRDALIHDAVLLAVILLTVVALAS
MWRGAVHGAAVGVGVLASYLAALGVSIALWQHLLDRELNALVPLVSFAVLASCGVPYLVA
GIKAGRIADEATGARSKGAVSGRGAVAPLAALGGVFGAGLVLVSGGSFSVLSQIGTVVVL
GLGVLITVQRAWLPTTPGRR*

Genomic Sequence

>Rv2942
ATGCCTAGTCCGGCTGGCCGTCTACACAGAATTCGGTATATCCGTTTGAAAAAGTCCTCC
CCGGACTGCCGCGCCACCATCACCAGCGGGTCAGCCGACGGTCAGCGAAGGTCACCCCGG
CTCACCAACCTGCTCGTCGTCGCCGCCTGGGTTGCCGCGGCGGTGATCGCAAATCTGCTT
CTCACGTTCACGCAAGCAGAACCGCACGACACCAGCCCGGCGCTGCTGCCACAAGATGCC
AAGACAGCCGCCGCCACCAGCCGGATTGCGCAGGCTTTCCCCGGCACCGGTAGCAACGCT
ATCGCCTATCTCGTCGTGGAAGGCGGCAGCACGCTTGAGCCGCAGGACCAGCCTTACTAC
GACGCCGCCGTCGGTGCCCTGCGCGCCGACACCCGCCACGTGGGATCCGTCCTCGACTGG
TGGTCAGATCCCGTCACCGCCCCGCTGGGAACCAGCCCCGACGGCCGCTCCGCTACGGCC
ATGGTGTGGCTGCGGGGCGAGGCGGGCACCACCCAAGCTGCCGAATCCCTCGATGCCGTC
CGATCGGTGCTGCGCCAGTTACCGCCCAGTGAGGGGCTTCGCGCCAGCATCGTGGTCCCG
GCAATCACCAACGACATGCCGATGCAGATAACCGCCTGGCAGAGCGCGACGATCGTGACC
GTTGCGGCGGTGATCGCCGTCCTACTGCTGCTGCGGGCGCGCCTGTCGGTGCGGGCCGCG
GCGATCGTGCTGCTGACCGCGGACTTGTCGCTTGCGGTGGCCTGGCCGCTGGCCGCGGTG
GTGCGGGGACACGATTGGGGAACCGATTCGGTATTTTCTTGGACGCTGGCCGCGGTCCTG
ACGATCGGAACCATCACCGCAGCCACCATGCTGGCCGCGCGGCTCGGGTCCGACGCAGGT
CATTCGGCCGCGCCCACATACCGCGACAGCCTGCCCGCGTTCGCCCTGCCCGGGGCGTGT
GTCGCCATATTCACCGGCCCGCTGCTGCTGGCCCGAACCCCAGCGCTGCACGGAGTTGGC
ACTGCCGGGCTAGGTGTCTTTGTGGCACTTGCGGCTTCGTTGACGGTGCTGCCTGCCCTG
ATCGCGCTTGCCGGAGCGTCACGGCAGTTACCGGCACCAACCACGGGTGCCGGCTGGACA
GGCCGGTTGTCGCTACCCGTCTCTTCTGCTTCGGCCCTGGGCACAGCGGCAGTGCTGGCG
ATCTGCATGCTACCCATCATCGGGATGCGGTGGGGTGTGGCCGAGAACCCGACAAGGCAA
GGCGGCGCACAAGTCCTTCCGGGGAATGCGCTTCCCGATGTGGTGGTGATCAAATCCGCT
CGGGACCTGAGGGACCCAGCCGCGCTCATCGCCATCAACCAGGTCAGCCACCGTCTGGTG
GAGGTTCCCGGTGTGCGCAAGGTGGAGTCGGCGGCATGGCCGGCCGGTGTCCCGTGGACC
GACGCCTCGCTCAGTTCCGCGGCCGGCAGGCTCGCCGACCAGCTGGGTCAGCAGGCCGGA
TCGTTCGTGCCGGCGGTGACTGCGATCAAATCGATGAAGTCCATAATCGAACAGATGAGC
GGCGCGGTCGACCAACTGGACAGCACCGTGAACGTGACTCTCGCCGGGGCAAGGCAAGCA
CAGCAATACCTCGATCCCATGCTCGCCGCCGCGCGGAACCTCAAAAACAAAACCACCGAA
CTGTCGGAATACCTGGAAACGATCCACACCTGGATTGTCGGCTTCACAAACTGCCCCGAC
GACGTCCTGTGCACGGCCATGCGCAAGGTCATTGAACCCTACGACATCGTGGTCACCGGC
ATGAACGAGCTGTCCACTGGCGCCGACCGCATCTCCGCGATATCGACACAGACAATGAGC
GCGTTGTCCTCGGCACCGCGGATGGTGGCGCAGATGCGGTCGGCGCTAGCACAGGTGCGC
TCGTTCGTACCCAAGCTGGAAACAACCATCCAGGACGCCATGCCGCAAATAGCGCAGGCG
TCGGCGATGCTGAAGAATCTCAGCGCCGATTTCGCCGATACCGGTGAGGGCGGCTTCCAC
CTGTCCAGGAAGGACCTGGCGGACCCGTCGTACCGGCACGTACGGGAATCGATGTTCTCG
TCAGACGGAACCGCCACCCGGCTGTTCCTCTATTCTGACGGACAACTGGACCTTGCTGCG
GCAGCACGCGCGCAGCAGCTCGAGATCGCCGCGGGCAAGGCGATGAAATACGGAAGCCTG
GTCGACAGCCAGGTCACGGTGGGTGGGGCCGCGCAAATAGCCGCGGCTGTCCGCGATGCC
CTCATCCACGATGCTGTGCTACTGGCCGTTATCTTGCTCACGGTAGTGGCTCTGGCCAGC
ATGTGGCGCGGTGCCGTCCACGGTGCTGCGGTTGGCGTGGGTGTGCTGGCCTCTTACCTC
GCCGCCCTGGGGGTCTCGATTGCACTGTGGCAACACCTACTGGATCGCGAGCTCAACGCC
TTGGTCCCGCTGGTGTCGTTCGCCGTCCTCGCTTCGTGCGGCGTCCCGTATCTCGTTGCC
GGCATCAAAGCCGGTCGTATCGCCGACGAGGCAACGGGTGCGCGGTCCAAGGGGGCGGTA
TCCGGGCGGGGAGCGGTTGCGCCGCTTGCGGCGCTCGGTGGCGTATTCGGCGCTGGCCTG
GTGCTGGTGTCGGGAGGTTCCTTCAGCGTGCTCAGTCAGATTGGCACGGTTGTTGTGCTC
GGTCTGGGCGTGCTGATCACGGTGCAGCGAGCGTGGCTTCCGACCACGCCAGGGCGGCGT
TGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Signaling Rv0931c	active	priyadarshinipriyanka2001	2012-10-05
	spectrophotometric Analysis J. Pérez, R. Garcia et al. Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD. Biochem. Biophys. Res. Commun. 2006
Name	RND superfamily inner membrane transporter involved in phthiocerol dimycocerosates translocation across the plasma membrane	active	mjackson	2012-10-05
	Phthiocerol dimycocerosates (PDIM), phenolic glycolipids (PGL) and para-hydroxybenzoic acid derivatives
Other	TBPWY:Phthiocerol dimycocerosates, PGL & pHBAD	active	mjackson	2012-03-05
	RND superfamily inner membrane transporter involved in phthiocerol dimycocerosates translocation across the plasma membrane M. Jain & JS. Cox Interaction between polyketide synthase and transporter suggests coupled synthesis and export of virulence lipid in M. tuberculosis. PLoS Pathog. 2005
Other	TBPWY:Phthiocerol dimycocerosates, PGL & pHBAD	active	mjackson	2012-03-05
	RND superfamily inner membrane transporter involved in phthiocerol dimycocerosates translocation across the plasma membrane LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Other	TBPWY:Phthiocerol dimycocerosates, PGL & pHBAD	active	mjackson	2012-03-05
	RND superfamily inner membrane transporter involved in phthiocerol dimycocerosates translocation across the plasma membrane authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Other	EC:	active	jjmcfadden	2012-03-05
	Inferred from direct assay M. Jain & JS. Cox Interaction between polyketide synthase and transporter suggests coupled synthesis and export of virulence lipid in M. tuberculosis. PLoS Pathog. 2005