Rv2959c - methyltransferase/methylase

Expression: Most Significant Conditions for Rv2959c

Protein Domains

Gene Information
Locus	Rv2959c
Symbol
Gene Name	methyltransferase/methylase
Location	3312101 - 3312838 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:738 bp Protein:246 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	9204
Related Genes	ML0127 MT3035
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2959c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2959c Transcript 1
MGLVWRSRTSLVGQLIGLVRLVASFAAQLFYRPSDAVAEEYHKWYYGNLVWTKTTYMGIN
CWKSVSDMWNYQEILSELQPSLVIEFGTRYGGSAVYFANIMRQIGQPFKVLTVDNSHKAL
DPRARREPDVLFVESSSTDPAIAEQIQRLKNEYPGKIFAILDSDHSMNHVLAEMKLLRPL
LSAGDYLVVEDSNINGHPVLPGFGPGPYEAIEAYEDEFPNDYKHDAERENKFGWTSAPNG
FLIRN*

Genomic Sequence

>Rv2959c
ATGGGGCTAGTGTGGCGCAGTCGGACTAGTCTTGTAGGGCAACTGATCGGACTAGTCAGG
TTAGTGGCGAGTTTTGCGGCCCAGTTATTCTACCGGCCGAGCGACGCAGTGGCGGAAGAA
TACCACAAGTGGTACTACGGCAACTTAGTGTGGACGAAGACCACTTATATGGGGATCAAT
TGCTGGAAATCCGTCAGCGATATGTGGAATTACCAGGAGATCCTGAGCGAGTTGCAACCA
TCCCTCGTCATCGAGTTCGGCACCCGCTACGGCGGCTCGGCGGTGTATTTTGCCAACATC
ATGAGGCAGATCGGCCAGCCATTCAAGGTACTTACCGTGGACAACTCACACAAAGCCCTC
GATCCAAGAGCCCGGCGCGAACCAGATGTTTTGTTCGTTGAATCGTCATCCACCGACCCG
GCGATTGCCGAACAAATTCAACGCCTCAAAAACGAATACCCTGGCAAGATCTTCGCCATC
TTAGATAGCGACCACTCGATGAATCATGTGCTGGCCGAGATGAAATTACTACGGCCGCTA
CTCTCCGCCGGTGACTACCTAGTAGTCGAGGATTCCAACATCAACGGCCACCCAGTCCTG
CCCGGGTTTGGGCCTGGACCCTATGAAGCGATCGAGGCATATGAGGATGAATTTCCAAAC
GATTACAAGCATGATGCGGAGCGGGAGAACAAATTCGGCTGGACTTCCGCGCCCAACGGA
TTTCTGATCCGCAACTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Operon Rv2958c	active	priti.priety	2012-10-05
	Methylation interface E. Pérez, P. Constant et al. Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex. J. Biol. Chem. 2004
Interaction	RegulatedBy Rv0348	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Name	SAM-dependent methyltransferase responsible for the O-methylation of the hydroxyl group at position 2 of the rhamnosyl residue linked to the phenolic group of phenolic glycolipids and p-hydroxybenzoic acid derivatives	active	mjackson	2012-10-05
	Phthiocerol dimycocerosates (PDIM), phenolic glycolipids (PGL) and para-hydroxybenzoic acid derivatives
Other	TBPWY:Phthiocerol dimycocerosates, PGL & pHBAD	active	mjackson	2012-03-05
	SAM-dependent methyltransferase responsible for the O-methylation of the hydroxyl group at position 2 of the rhamnosyl residue linked to the phenolic group of phenolic glycolipids and p-hydroxybenzoic acid derivatives (phenotypic [mycobacterial recombinant strains]) E. Pérez, P. Constant et al. Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex. J. Biol. Chem. 2004
Term	EC:2.1.1.- Transferases. Transferring one-carbon groups. Methyltransferases. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay E. Pérez, P. Constant et al. Characterization of three glycosyltransferases involved in the biosynthesis of the phenolic glycolipid antigens from the Mycobacterium tuberculosis complex. J. Biol. Chem. 2004