Rv2965c - phosphopantetheine adenylyltransferase kdtB
Protein Domains

Gene Information
LocusRv2965c
SymbolcoaD
Gene Namephosphopantetheine adenylyltransferase kdtB
Location3318330 - 3318815 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:486 bp
Protein:162 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number568
Related GenesAcel_1578 BL0291 CE1441 cg1501 DIP1139 jk1209 MAP3002c MAV_3810 Mkms_1991 ML1663 Mmcs_1945 MSMEG_2414 MT3043 MUL_1994 Mvan_2167 nfa41890 PPA1463 SAV2669
Transcriptional Regulation
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Regulatory Network
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Expression Correlation Genes with Correlated Expression
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Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
SymbolkdtBactivejevans2012-03-16
CoA only binds Mtb PPAT in one conformation
authors,T. Wubben,AD. Mesecar Structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase in complex with the feedback inhibitor CoA reveals only one active-site conformation. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2011
SymbolkdtBactivejevans2012-03-16
Ligand binding results in asymmetry and alters the structure of the solvent channel - ligand binding restricted to one tetramer of the symmetrical hexamer
VK. Morris,T. Izard Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase. Protein Sci. 2004
TermEC:2.7.7.3 Pantetheine-phosphate adenylyltransferase. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
KL. Brown, VK. Morris et al. Rhombohedral crystals of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase. Acta Crystallogr. D Biol. Crystallogr. 2004