Rv3080c - serine/threonine-protein kinase transcriptional regulator pknK

Expression: Most Significant Conditions for Rv3080c

Protein Domains

Gene Information
Locus	Rv3080c
Symbol	pknK
Gene Name	serine/threonine-protein kinase transcriptional regulator pknK
Location	3442656 - 3445988 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:3333 bp Protein:1111 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	37168
Related Genes	MT3165 MUL_4753 MUL_4754
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3080c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3080c Transcript 1
MTDVDPHATRRDLVPNIPAELLEAGFDNVEEIGRGGFGVVYRCVQPSLDRAVAVKVLSTD
LDRDNLERFLREQRAMGRLSGHPHIVTVLQVGVLAGGRPFIVMPYHAKNSLETLIRRHGP
LDWRETLSIGVKLAGALEAAHRVGTLHRDVKPGNILLTDYGEPQLTDFGIARIAGGFETA
TGVIAGSPAFTAPEVLEGASPTPASDVYSLGATLFCALTGHAAYERRSGERVIAQFLRIT
SQPIPDLRKQGLPADVAAAIERAMARHPADRPATAADVGEELRDVQRRNGVSVDEMPLPV
ELGVERRRSPEAHAAHRHTGGGTPTVPTPPTPATKYRPSVPTGSLVTRSRLTDILRAGGR
RRLILIHAPSGFGKSTLAAQWREELSRDGAAVAWLTIDNDDNNEVWFLSHLLESIRRVRP
TLAESLGHVLEEHGDDAGRYVLTSLIDEIHENDDRIAVVIDDWHRVSDSRTQAALGFLLD
NGCHHLQLIVTSWSRAGLPVGRLRIGDELAEIDSAALRFDTDEAAALLNDAGGLRLPRAD
VQALTTSTDGWAAALRLAALSLRGGGDATQLLRGLSGASDVIHEFLSENVLDTLEPELRE
FLLVASVTERTCGGLASALAGITNGRAMLEEAEHRGLFLQRTEDDPNWFRFHQMFADFLH
RRLERGGSHRVAELHRRASAWFAENGYLHEAVDHALAAGDPARAVDLVEQDETNLPEQSK
MTTLLAIVQKLPTSMVVSRARLQLAIAWANILLQRPAPATGALNRFETALGRAELPEATQ
ADLRAEADVLRAVAEVFADRVERVDDLLAEAMSRPDTLPPRVPGTAGNTAALAAICRFEF
AEVYPLLDWAAPYQEMMGPFGTVYAQCLRGMAARNRLDIVAALQNFRTAFEVGTAVGAHS
HAARLAGSLLAELLYETGDLAGAGRLMDESYLLGSEGGAVDYLAARYVIGARVKAAQGDH
EGAADRLSTGGDTAVQLGLPRLAARINNERIRLGIALPAAVAADLLAPRTIPRDNGIATM
TAELDEDSAVRLLSAGDSADRDQACQRAGALAAAIDGTRRPLAALQAQILHIETLAATGR
ESDARNELAPVATKCAELGLSRLLVDAGLA*

Genomic Sequence

>Rv3080c
ATGACCGACGTTGATCCGCACGCGACGCGGCGGGACCTGGTCCCGAATATTCCCGCGGAA
CTGCTTGAGGCTGGATTCGACAATGTCGAGGAGATCGGGCGCGGCGGATTCGGCGTCGTC
TACCGCTGCGTCCAGCCCTCGCTGGACCGCGCCGTCGCCGTCAAGGTATTGAGCACCGAC
CTGGATCGGGACAATCTCGAGCGCTTCCTGCGCGAGCAGCGGGCCATGGGCCGCCTTTCC
GGGCACCCGCACATCGTGACCGTCTTGCAGGTGGGCGTGTTGGCGGGTGGGCGGCCCTTC
ATCGTGATGCCCTACCACGCCAAGAATTCGTTGGAGACGCTGATTCGCCGGCACGGGCCG
CTGGACTGGCGCGAGACGCTGTCGATCGGCGTCAAGCTCGCGGGAGCGCTGGAAGCCGCG
CATCGCGTCGGCACCCTGCACCGTGACGTGAAGCCGGGGAATATCCTGCTGACCGACTAC
GGGGAACCGCAGCTGACCGATTTCGGAATCGCCAGAATCGCCGGGGGTTTCGAGACGGCG
ACCGGGGTGATTGCCGGTTCCCCGGCTTTCACCGCGCCGGAAGTTCTCGAAGGAGCATCG
CCGACGCCCGCCTCTGACGTGTACTCCCTGGGCGCGACGTTGTTCTGTGCGCTGACCGGC
CATGCCGCCTACGAGCGCCGCAGCGGTGAGCGGGTGATCGCCCAGTTCCTGCGGATCACC
TCGCAGCCGATCCCCGACCTGCGGAAGCAGGGACTGCCCGCGGACGTGGCCGCCGCCATC
GAACGGGCGATGGCCCGCCATCCGGCGGATCGTCCCGCGACCGCGGCAGACGTTGGCGAG
GAGCTTCGCGACGTTCAGCGCCGCAACGGCGTCAGCGTCGACGAGATGCCCCTCCCCGTC
GAGCTGGGCGTGGAACGCCGACGCTCGCCCGAGGCGCACGCGGCGCATCGGCATACCGGC
GGCGGCACCCCGACGGTCCCGACGCCTCCGACACCCGCGACCAAGTACCGGCCGTCGGTG
CCCACCGGCTCGCTGGTCACCCGCAGCCGGCTCACCGACATCCTGCGCGCCGGCGGACGG
CGCCGGCTGATCCTCATCCACGCGCCCTCGGGATTCGGCAAAAGCACCCTGGCGGCGCAA
TGGCGGGAAGAGCTCTCGCGCGACGGCGCCGCGGTCGCCTGGCTGACAATCGACAACGAC
GACAACAACGAGGTGTGGTTCTTGTCGCACCTGCTCGAGTCGATCCGGCGGGTCCGGCCC
ACGCTGGCCGAGTCGTTGGGGCACGTGCTCGAAGAGCATGGGGATGACGCCGGCCGCTAC
GTGTTGACTTCGCTGATCGACGAAATCCACGAAAACGACGACCGGATCGCGGTGGTGATC
GACGACTGGCATCGGGTGTCCGACAGCCGCACCCAAGCTGCCCTGGGTTTCCTGCTGGAC
AACGGATGTCACCACCTGCAGCTCATCGTGACCAGCTGGTCTCGCGCCGGTTTGCCGGTG
GGCAGGTTGCGGATCGGCGACGAACTAGCCGAGATCGATTCGGCTGCTTTGCGCTTCGAT
ACCGACGAGGCCGCCGCGCTGCTGAACGATGCTGGTGGTCTGCGATTGCCGCGCGCAGAC
GTGCAGGCGCTGACTACCTCTACCGACGGGTGGGCCGCGGCGCTGCGGCTGGCCGCGCTG
TCGCTGCGCGGCGGGGGCGACGCGACCCAACTCCTGCGCGGACTTTCCGGCGCCAGTGAC
GTGATCCACGAATTCCTGAGCGAAAACGTGCTGGACACCCTGGAACCCGAACTGCGCGAA
TTCCTACTGGTGGCATCGGTCACCGAACGCACGTGCGGCGGGCTGGCCTCGGCGCTGGCC
GGGATCACCAATGGGCGGGCGATGCTGGAAGAGGCCGAGCACCGCGGCTTGTTCCTGCAA
CGGACCGAAGACGACCCGAATTGGTTTCGCTTCCACCAAATGTTCGCCGACTTTCTCCAC
CGTCGCCTCGAACGTGGCGGGTCGCACCGGGTGGCGGAACTGCACCGCAGGGCATCGGCC
TGGTTCGCCGAGAACGGCTACCTGCACGAAGCCGTCGACCATGCACTGGCCGCGGGCGAT
CCCGCGCGCGCCGTCGATCTTGTCGAGCAGGATGAAACGAACCTGCCGGAGCAGTCAAAG
ATGACCACACTTCTGGCAATCGTGCAGAAACTGCCGACGTCGATGGTGGTTTCACGGGCC
CGGCTCCAACTCGCCATCGCGTGGGCGAACATTCTGCTGCAACGGCCGGCGCCGGCCACC
GGTGCCCTGAATCGTTTCGAAACGGCCCTTGGCCGGGCCGAGCTTCCCGAGGCGACGCAG
GCGGATCTGCGGGCCGAGGCAGACGTGTTGCGGGCGGTCGCCGAGGTGTTCGCAGACCGG
GTCGAGCGCGTGGATGACCTTCTCGCCGAGGCAATGTCGAGACCGGACACCCTGCCCCCG
CGAGTCCCCGGGACCGCCGGCAACACCGCGGCGTTGGCCGCGATCTGCCGCTTCGAGTTC
GCCGAGGTATATCCACTGCTGGACTGGGCCGCGCCCTACCAGGAAATGATGGGACCGTTC
GGCACCGTTTATGCGCAGTGCTTGCGCGGCATGGCGGCCAGGAATCGGCTCGACATTGTC
GCTGCGCTACAGAACTTCCGAACGGCGTTCGAGGTCGGCACGGCAGTGGGGGCCCACTCG
CACGCGGCGCGGCTTGCGGGTTCGCTGCTCGCCGAATTGCTCTACGAGACCGGCGATCTG
GCCGGGGCTGGTCGTCTCATGGACGAGAGCTATCTGCTGGGTTCCGAGGGGGGTGCAGTG
GACTACCTGGCCGCCAGGTACGTGATCGGCGCGCGGGTCAAGGCGGCCCAGGGGGATCAT
GAGGGTGCGGCTGATCGCCTGTCCACCGGAGGCGATACTGCCGTCCAGCTGGGGCTGCCG
CGCCTGGCTGCCCGAATCAACAACGAGCGGATCCGGCTGGGCATCGCGCTACCTGCGGCG
GTGGCCGCCGATTTGCTGGCACCCCGCACCATCCCCCGCGACAATGGAATCGCCACCATG
ACAGCCGAACTCGACGAGGACTCCGCGGTGCGCCTGTTGTCCGCCGGCGACTCCGCCGAT
CGTGACCAAGCCTGCCAACGGGCCGGTGCTCTCGCCGCCGCCATCGACGGTACGCGCAGA
CCGCTGGCGGCGCTGCAGGCGCAAATACTTCATATCGAAACGCTTGCCGCCACCGGACGG
GAATCCGATGCGCGAAACGAACTGGCGCCGGTAGCCACGAAGTGCGCCGAACTCGGGCTG
TCACGTCTGCTGGTCGATGCGGGACTGGCCTAA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Activation Rv3088	active	sourish10	2012-10-05
	Structural Analysis P. Kumar, D. Kumar et al. The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS. J. Biol. Chem. 2009
Interaction	Activation Rv3088	active	sourish10	2012-10-05
	Spectrophotometric P. Kumar, D. Kumar et al. The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS. J. Biol. Chem. 2009
Interaction	Activation Rv3085	active	sourish10	2012-10-05
	Structural Analysis P. Kumar, D. Kumar et al. The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS. J. Biol. Chem. 2009
Interaction	Activation Rv3085	active	sourish10	2012-10-05
	Spectrophotometric P. Kumar, D. Kumar et al. The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS. J. Biol. Chem. 2009
Interaction	Activation Rv3084	active	sourish10	2012-10-05
	Structural Analysis P. Kumar, D. Kumar et al. The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS. J. Biol. Chem. 2009
Interaction	Activation Rv3084	active	sourish10	2012-10-05
	Spectrophotometric P. Kumar, D. Kumar et al. The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS. J. Biol. Chem. 2009
Interaction	Activation Rv3083	active	priyadarshinipriyanka2001	2012-10-05
	Structural Analysis P. Kumar, D. Kumar et al. The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS. J. Biol. Chem. 2009
Interaction	Activation Rv3083	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometric P. Kumar, D. Kumar et al. The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS. J. Biol. Chem. 2009
Interaction	Activation Rv3085	active	priyadarshinipriyanka2001	2012-10-05
	Affinity purification (Physical interaction) P. Kumar, D. Kumar et al. The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS. J. Biol. Chem. 2009
Interaction	Activation Rv3084	active	priyadarshinipriyanka2001	2012-10-05
	Affinity purification (Physical interaction) P. Kumar, D. Kumar et al. The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS. J. Biol. Chem. 2009
Interaction	Signaling Rv1354c	active	swetha.r	2012-10-05
	Yeast two-hybrid (Physical interaction) T. Cui, L. Zhang et al. Uncovering new signaling proteins and potential drug targets through the interactome analysis of Mycobacterium tuberculosis. BMC Genomics 2009
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv3291c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	Regulates Rv2117	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	Regulates Rv1781c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	Regulates Rv1328	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	Regulates Rv1238	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	Regulates Rv1237	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	Regulates Rv1235	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Interaction	RegulatedBy Rv3291c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Interaction	Regulates Rv2117	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Interaction	Regulates Rv1781c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Interaction	Regulates Rv1328	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Interaction	Regulates Rv1238	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Interaction	Regulates Rv1237	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Interaction	Regulates Rv1235	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006