Rv3140 - acyl-CoA dehydrogenase fadE23

Expression: Most Significant Conditions for Rv3140

Protein Domains

Gene Information
Locus	Rv3140
Symbol	fadE23
Gene Name	acyl-CoA dehydrogenase fadE23
Location	3506790 - 3507995 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1206 bp Protein:402 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	14433
Related Genes	MAP3189 MAV_4019 MT3227 MUL_2432
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3140
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3140 Transcript 1
MAINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVELDTLINLFEGAAESFNF
AGAHSLRDEDEGKDENHNGANMAAVVQTMEASWGDVAMMLSLPYQGLGNAAISAVATDEQ
LERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVINGEKIFVTAGSRATHIVVWATL
DKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTAVIRFDNARIPKGNLLGNPEIEV
GKGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSVLTGAGVEISYDKPSHTQSAAAAEF
LRMEADWEASYLLSLRAAWQADNNIPNSKEASMSKAKAGRMASDVTCKTVELAGTTGYSE
QSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSSELK*

Genomic Sequence

>Rv3140
ATGGCAATAAATCTGGAACTGCCGCGCAAGCTGCAGGCGATCATCGTCAAGACCCATCAG
GGCGCTGCGGAGATGATGCGGCCGATAGCCCGCAAGTACGACCTGAAGGAACATGCCTAC
CCGGTCGAACTCGACACCCTGATCAATTTGTTCGAGGGCGCCGCCGAATCGTTCAACTTT
GCCGGAGCCCATTCGCTTCGCGACGAGGACGAAGGCAAGGACGAAAACCACAACGGTGCC
AACATGGCCGCCGTGGTACAGACGATGGAGGCCAGCTGGGGCGACGTCGCGATGATGCTG
TCGCTGCCCTATCAGGGGCTGGGTAACGCAGCCATCTCCGCGGTAGCCACCGACGAGCAG
CTGGAGCGGCTGGGCAAAGTGTGGGCAGCGATGGCCATCACCGAACCGGAATTCGGATCG
GACTCGGCGGCAGTGTCGACGACCGCCACCCTCGACGGCGACGAGTACGTGATCAACGGC
GAGAAGATCTTTGTCACCGCCGGTTCCCGCGCCACCCACATCGTGGTCTGGGCCACGCTG
GACAAATCCTTGGGCCGCCCGGCGATTAAGTCGTTCATCGTGCCCCGTGAGCATCCCGGC
GTGACCGTCGAACGACTTGAACACAAACTCGGCATCAAGGGTTCTGATACTGCGGTGATC
CGGTTCGACAACGCCCGTATCCCCAAGGGCAACCTACTTGGGAACCCGGAAATCGAGGTC
GGCAAGGGCTTTGCCGGGGTGATGGAGACCTTCGACAACACCCGGCCGATTGTGGCCGCC
ATGGCCGTCGGGATCGGCCGTGCCGCACTGGAGGAAATCCGTAGTGTCCTCACCGGGGCC
GGCGTGGAGATCTCCTACGACAAGCCCTCACACACCCAGAGCGCCGCGGCCGCCGAGTTC
CTGCGGATGGAGGCCGACTGGGAGGCCAGCTACCTACTGTCCCTGCGCGCAGCCTGGCAG
GCCGACAACAACATCCCCAACTCCAAAGAAGCCTCGATGAGCAAGGCCAAGGCGGGCCGG
ATGGCCAGCGACGTCACCTGCAAAACCGTCGAATTGGCAGGAACTACCGGGTATTCCGAG
CAATCACTGCTGGAGAAGTGGGCCCGCGACTCCAAGATCCTGGACATCTTCGAGGGCACC
CAGCAGATCCAGCAGCTGGTGGTCGCACGCCGACTGTTGGGCCTGTCGTCGTCCGAGCTC
AAATAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv1221	active	jhum4u2006	2012-10-05
	Co-expression (Functional linkage) PC. Karakousis, EP. Williams et al. Altered expression of isoniazid-regulated genes in drug-treated dormant Mycobacterium tuberculosis. J. Antimicrob. Chemother. 2008
Interaction	Regulatory Rv1221	active	jhum4u2006	2012-10-05
	Co-expression (Functional linkage) T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
Interaction	Regulatory Rv1221	active	jhum4u2006	2012-10-05
	Co-expression (Functional linkage) PA. Fontán, V. Aris et al. Mycobacterium tuberculosis Sigma Factor E Regulon Modulates the Host Inflammatory Response. J. Infect. Dis. 2008
Interaction	Regulatory Rv1221	active	jhum4u2006	2012-10-05
	Co-expression (Functional linkage) authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Interaction	Regulatory Rv1221	active	hibeeluck	2012-10-05
	Co-expression (Functional linkage) PC. Karakousis, EP. Williams et al. Altered expression of isoniazid-regulated genes in drug-treated dormant Mycobacterium tuberculosis. J. Antimicrob. Chemother. 2008
Interaction	Regulatory Rv1221	active	hibeeluck	2012-10-05
	Co-expression (Functional linkage) T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
Interaction	Regulatory Rv1221	active	hibeeluck	2012-10-05
	Co-expression (Functional linkage) PA. Fontán, V. Aris et al. Mycobacterium tuberculosis Sigma Factor E Regulon Modulates the Host Inflammatory Response. J. Infect. Dis. 2008
Interaction	Regulatory Rv1221	active	hibeeluck	2012-10-05
	Co-expression (Functional linkage) authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Interaction	RegulatedBy Rv0348	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Interaction	RegulatedBy Rv0182c	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. JH. Lee, DE. Geiman et al. Role of stress response sigma factor SigG in Mycobacterium tuberculosis. J. Bacteriol. 2008
Interaction	RegulatedBy Rv0981	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Interaction	RegulatedBy Rv1221	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
Interaction	RegulatedBy Rv1221	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. PA. Fontán, V. Aris et al. Mycobacterium tuberculosis Sigma Factor E Regulon Modulates the Host Inflammatory Response. J. Infect. Dis. 2008
Interaction	RegulatedBy Rv2711	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. GM. Rodriguez, MI. Voskuil et al. ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infect. Immun. 2002
Interaction	RegulatedBy Rv0491	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
Interaction	Regulatory Rv1221	active	jhum4u2006	2012-10-03
	Co-expression (Functional linkage) PC. Karakousis, EP. Williams et al. Altered expression of isoniazid-regulated genes in drug-treated dormant Mycobacterium tuberculosis. J. Antimicrob. Chemother. 2008
Interaction	Regulatory Rv1221	active	jhum4u2006	2012-10-03
	Co-expression (Functional linkage) T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
Interaction	Regulatory Rv1221	active	jhum4u2006	2012-10-03
	Co-expression (Functional linkage) PA. Fontán, V. Aris et al. Mycobacterium tuberculosis Sigma Factor E Regulon Modulates the Host Inflammatory Response. J. Infect. Dis. 2008
Interaction	Regulatory Rv1221	active	jhum4u2006	2012-10-03
	Co-expression (Functional linkage) authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Other	EC:1.3.8.-	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
Other	EC:1.3.8.1	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
Term	EC:1.3.99.3 Acyl-CoA dehydrogenase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
Term	EC:1.3.99.12 2-methylacyl-CoA dehydrogenase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:1.3.99.3 Acyl-CoA dehydrogenase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.16 Acetyl-CoA C-acyltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:1.1.1.35 3-hydroxyacyl-CoA dehydrogenase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:4.2.1.17 Enoyl-CoA hydratase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.17 Aspartate N-acetyltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.18 Galactoside O-acetyltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.19 Phosphate butyryltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.20 Diacylglycerol O-acyltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.21 Carnitine O-palmitoyltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.22 2-acylglycerol O-acyltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.23 1-acylglycerophosphocholine O-acyltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.24 Sphingosine N-acyltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.25 Plasmalogen synthase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.26 Sterol O-acyltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.27 Cortisol O-acetyltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.28 Chloramphenicol O-acetyltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.29 Glycine C-acetyltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998
Term	EC:2.3.1.30 Serine O-acetyltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,U. Mahadevan,G. Padmanaban Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 1998