Rv3246c - two component system transcriptional regulator mtrA
Protein Domains

Gene Information
LocusRv3246c
SymbolmtrA
Gene Nametwo component system transcriptional regulator mtrA
Location3626663 - 3627349 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:687 bp
Protein:229 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
Search Google Scholar
Orthologs
Orthogroup Number35369
Related GenesAcel_1765 CE0769 cg0862 DIP0694 jk1635 MAP3360c MAV_4209 Mkms_1365 ML0773 Mmcs_1347 MSMEG_1874 MT3344 MUL_2582 Mvan_1752 nfa46110 SAV5063
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
Search for regulators of Rv3246c
Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionSignaling Rv2069activesourish102012-10-05
Co-expression (Functional linkage)
R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
InteractionSignaling Rv3245cactivesourish102012-10-05
Co-expression (Functional linkage)
KK. Singh, X. Zhang et al. Antigens of Mycobacterium tuberculosis expressed during preclinical tuberculosis: serological immunodominance of proteins with repetitive amino acid sequences. Infect. Immun. 2001
InteractionSignaling Rv3245cactivesourish102012-10-05
Co-expression (Functional linkage)
TC. Zahrt & V. Deretic An essential two-component signal transduction system in Mycobacterium tuberculosis. J. Bacteriol. 2000
InteractionSignaling Rv3245cactivesourish102012-10-05
Co-expression (Functional linkage)
authors,GA. Cangelosi,JS. Do,R. Freeman,JG. Bennett,M. Semret,MA. Behr The two-component regulatory system mtrAB is required for morphotypic multidrug resistance in Mycobacterium avium. Antimicrob. Agents Chemother. 2006
InteractionSignaling Rv3245cactivesourish102012-10-05
Co-expression (Functional linkage)
KK. Singh, X. Zhang et al. Antigens of Mycobacterium tuberculosis expressed during preclinical tuberculosis: serological immunodominance of proteins with repetitive amino acid sequences. Infect. Immun. 2001
InteractionSignaling Rv3245cactivesourish102012-10-05
Co-expression (Functional linkage)
TC. Zahrt & V. Deretic An essential two-component signal transduction system in Mycobacterium tuberculosis. J. Bacteriol. 2000
InteractionSignaling Rv3245cactivesourish102012-10-05
Co-expression (Functional linkage)
authors,GA. Cangelosi,JS. Do,R. Freeman,JG. Bennett,M. Semret,MA. Behr The two-component regulatory system mtrAB is required for morphotypic multidrug resistance in Mycobacterium avium. Antimicrob. Agents Chemother. 2006
InteractionRegulatory Rv3244cactiveharsharohiratruefriend2012-10-05
Co-expression (Functional linkage)
authors,PA. Hoskisson,MI. Hutchings MtrAB-LpqB: a conserved three-component system in actinobacteria? Trends Microbiol. 2006
InteractionRegulatory Rv3244cactiveharsharohiratruefriend2012-10-05
Co-expression (Functional linkage)
N. Möker, M. Brocker et al. Deletion of the genes encoding the MtrA-MtrB two-component system of Corynebacterium glutamicum has a strong influence on cell morphology, antibiotics susceptibility and expression of genes involved in osmoprotection. Mol. Microbiol. 2004
InteractionRegulatory Rv2069activeashwinigbhat2012-10-05
Co-expression (Functional linkage)
R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
InteractionRegulatory Rv2069activepriti.priety2012-10-05
Co-expression (Functional linkage)
R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004