Rv3396c - GMP synthase guaA

Expression: Most Significant Conditions for Rv3396c

Protein Domains

Gene Information
Locus	Rv3396c
Symbol	guaA
Gene Name	GMP synthase guaA
Location	3812501 - 3814078 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1578 bp Protein:526 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	37000
Related Genes	Acel_0371 CE0615 CE0623 cg0703 cg0709 DIP0595 DIP0600 jk1720 MAP3489c MAV_4348 Mkms_1190 ML0395 Mmcs_1173 MSMEG_1610 MT3504 MUL_0913 Mvan_1516 nfa8970 PPA1657 PPA1658 SAV3479
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3396c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3396c Transcript 1
MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTASIEEIRARQPVA
LVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQAMAQALGGIVAHTGTREYGRTEL
KVLGGKLHSDLPEVQPVWMSHGDAVTAAPDGFDVVASSAGAPVAAFEAFDRRLAGVQYHP
EVMHTPHGQQVLSRFLHDFAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAV
AAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSGVS
APEGKRKIIGRQFIRAFEGAVRDVLDGKTAEFLVQGTLYPDVVESGGGSGTANIKSHHNV
GGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQPFPGPGLGIRIVGEVTAKRL
DTLRHADSIVREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDA
MTADWTRVPYEVLERISTRITNEVAEVNRVVLDITSKPPATIEWE*

Genomic Sequence

>Rv3396c
GTGGTGCAGCCTGCTGACATCGACGTGCCTGAGACACCGGCTCGACCGGTGTTGGTGGTC
GACTTCGGTGCCCAATATGCCCAGTTGATTGCCCGTCGGGTTCGAGAAGCACGGGTTTTC
TCCGAGGTGATTCCGCACACCGCCTCGATCGAGGAGATCAGGGCCCGTCAGCCGGTGGCG
CTCGTGCTTTCCGGTGGACCGGCCAGTGTCTACGCCGACGGCGCTCCGAAACTCGATCCG
GCGCTACTGGACCTCGGTGTACCGGTTCTTGGCATCTGCTACGGGTTTCAGGCCATGGCG
CAGGCGCTCGGGGGGATCGTCGCCCACACCGGCACTCGCGAATACGGTCGGACTGAACTG
AAAGTCCTTGGTGGCAAACTGCATTCGGATCTTCCCGAGGTTCAGCCGGTATGGATGAGT
CACGGTGACGCGGTCACGGCCGCGCCGGACGGATTCGACGTGGTGGCTAGCAGCGCCGGT
GCCCCGGTGGCCGCCTTCGAGGCCTTCGACCGGCGCCTGGCCGGGGTGCAGTATCACCCG
GAGGTGATGCACACCCCACACGGGCAACAGGTGCTCAGCCGGTTTTTGCACGACTTCGCC
GGGCTCGGCGCCCAGTGGACGCCCGCCAACATCGCCAACGCGCTGATCGAGCAGGTGCGC
ACCCAGATCGGCGACGGCCACGCCATCTGCGGGCTATCCGGCGGCGTGGATTCCGCGGTG
GCCGCGGCCCTGGTGCAGCGGGCCATCGGCGACCGGTTGACCTGTGTCTTCGTCGACCAC
GGGCTGTTGCGCGCCGGTGAGCGGGCGCAGGTGCAACGCGATTTCGTGGCCGCCACCGGC
GCCAACCTGGTCACCGTCGACGCGGCCGAGACCTTCCTCGAGGCGCTGTCGGGCGTGAGC
GCCCCCGAGGGCAAACGCAAGATCATCGGCCGTCAGTTCATCCGCGCGTTCGAGGGCGCG
GTGCGGGATGTGCTGGACGGTAAGACTGCTGAGTTCCTGGTGCAGGGCACGCTGTATCCG
GATGTGGTGGAGTCCGGCGGGGGCAGCGGCACCGCGAACATCAAGAGCCACCACAATGTC
GGCGGCCTGCCCGACGACCTGAAGTTCACCCTCGTTGAGCCGCTGCGGCTGCTGTTCAAA
GACGAGGTGCGCGCGGTCGGGCGGGAGTTGGGTCTGCCGGAGGAGATCGTGGCGCGCCAG
CCGTTTCCGGGACCGGGGTTGGGTATTCGGATCGTCGGGGAGGTCACCGCCAAGCGGTTG
GATACGCTGCGGCACGCCGATTCGATCGTGCGTGAGGAGCTGACCGCGGCGGGCCTGGAC
AACCAGATCTGGCAGTGTCCGGTGGTGCTGTTGGCCGATGTCCGCTCGGTGGGTGTGCAG
GGTGACGGTCGCACCTATGGCCACCCGATTGTGCTGCGTCCGGTGTCGAGTGAAGACGCG
ATGACCGCCGACTGGACCCGGGTGCCCTACGAGGTGCTCGAGCGCATCTCGACCCGGATC
ACCAACGAGGTCGCCGAGGTCAACCGCGTGGTGCTGGACATCACCAGCAAGCCGCCCGCC
ACCATCGAGTGGGAGTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv3911	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. S. Raman, X. Puyang et al. Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis. J. Bacteriol. 2006
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv3575c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv0001	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Interaction	RegulatedBy Rv3575c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Interaction	RegulatedBy Rv0001	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006