Rv3449 - membrane-anchored mycosin mycP4

Expression: Most Significant Conditions for Rv3449

Protein Domains

Gene Information
Locus	Rv3449
Symbol	mycP4
Gene Name	membrane-anchored mycosin mycP4
Location	3869752 - 3871119 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1368 bp Protein:456 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	29297
Related Genes	CE0578 cg0665 DIP0554 jk1752 MAP4239c MAV_4393 Mkms_1141 Mmcs_1124 MSMEG_1533 MT3555 MUL_0858 Mvan_1445 nfa8490
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3449
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3449 Transcript 1
MTTSRTLRLLVVSALATLSGLGTPVAHAVSPPPIDERWLPESALPAPPRPTVQREVCTEV
TAESGRAFGRAERSAQLADLDQVWRLTRGAGQRVAVIDTGVARHRRLPKVVAGGDYVFTG
DGTADCDAHGTLVAGIIAAAPDAQSDNFSGVAPDVTLISIRQSSSKFAPVGDPSSTGVGD
VDTMAKAVRTAADLGASVINISSIACVPAAAAPDDRALGAALAYAVDVKNAVIVAAAGNT
GGAAQCPPQAPGVTRDSVTVAVSPAWYDDYVLTVGSVNAQGEPSAFTLAGPWVDVAATGE
AVTSLSPFGDGTVNRLGGQHGSIPISGTSYAAPVVSGLAALIRARFPTLTARQVMQRIES
TAHHPPAGWDPLVGNGTVDALAAVSSDSIPQAGTATSDPAPVAVPVPRRSTPGPSDRRAL
HTAFAGAAICLLALMATLATASRRLRPGRNGIAGD*

Genomic Sequence

>Rv3449
ATGACCACGTCCCGTACCCTGCGCCTGCTGGTGGTATCAGCGCTCGCGACGCTGTCTGGG
TTGGGAACGCCGGTTGCCCACGCGGTTTCGCCGCCGCCGATCGACGAAAGATGGCTACCC
GAATCTGCGCTGCCGGCGCCGCCGCGGCCGACCGTACAACGTGAGGTATGCACCGAGGTC
ACCGCCGAATCGGGACGGGCTTTCGGCCGGGCTGAGCGGTCCGCTCAACTCGCCGACCTC
GACCAGGTCTGGCGACTCACCCGCGGCGCCGGCCAACGGGTCGCGGTCATCGACACCGGC
GTTGCGCGCCATCGACGGTTGCCCAAGGTGGTTGCCGGCGGTGACTATGTCTTCACCGGG
GACGGCACCGCGGATTGCGATGCACACGGCACGCTGGTGGCCGGAATTATCGCGGCCGCA
CCGGATGCGCAAAGCGACAATTTCAGCGGGGTGGCACCCGATGTCACCTTGATCAGCATT
CGCCAGTCCAGCAGCAAGTTCGCACCGGTCGGCGACCCGTCCAGCACAGGTGTTGGTGAC
GTCGACACCATGGCGAAGGCCGTGCGGACGGCCGCCGACCTCGGCGCGTCGGTGATCAAC
ATCTCGTCGATTGCCTGCGTTCCGGCCGCGGCTGCGCCGGACGACCGCGCGCTAGGTGCC
GCTTTGGCCTATGCGGTCGATGTCAAGAACGCCGTCATCGTGGCCGCGGCCGGCAATACC
GGCGGCGCCGCGCAGTGTCCGCCGCAGGCCCCCGGGGTAACCCGGGACAGCGTCACGGTT
GCGGTGAGTCCGGCCTGGTACGACGACTACGTGCTGACCGTAGGTTCGGTGAACGCCCAA
GGCGAACCCTCGGCATTCACTCTCGCCGGCCCCTGGGTGGATGTCGCCGCCACCGGCGAG
GCGGTGACCTCGCTCAGCCCGTTCGGTGACGGGACCGTGAACAGGCTTGGCGGACAGCAT
GGTTCGATTCCGATATCCGGAACCAGTTATGCGGCGCCGGTCGTCAGCGGCCTGGCCGCC
CTGATCCGGGCCCGCTTTCCGACGTTGACCGCACGGCAGGTGATGCAGCGCATCGAATCT
ACCGCGCATCACCCACCCGCCGGATGGGATCCGCTCGTCGGCAACGGCACGGTCGATGCC
CTGGCTGCGGTCAGCAGCGACTCGATTCCGCAGGCCGGCACCGCAACGAGCGACCCCGCT
CCGGTGGCGGTGCCGGTCCCTAGGCGGTCAACGCCCGGCCCATCGGATCGCCGCGCCCTA
CACACCGCCTTTGCTGGTGCCGCGATCTGCCTGCTCGCGCTGATGGCAACCCTGGCCACC
GCCAGCCGCCGGCTACGGCCCGGGCGCAACGGTATCGCGGGCGACTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv3911	active	harsharohiratruefriend	2012-10-05
	Co-expression (Functional linkage) JA. Dave, NC. Gey van Pittius et al. Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages. BMC Microbiol. 2002
Interaction	RegulatedBy Rv3911	active	harsharohiratruefriend	2012-10-05
	Co-expression (Functional linkage) N. Agarwal, SC. Woolwine et al. Characterization of the Mycobacterium tuberculosis sigma factor SigM by assessment of virulence and identification of SigM-dependent genes. Infect. Immun. 2007
Interaction	RegulatedBy Rv3911	active	harsharohiratruefriend	2012-10-05
	Co-expression (Functional linkage) GD. Brown, JA. Dave et al. The mycosins of Mycobacterium tuberculosis H37Rv: a family of subtilisin-like serine proteases. Gene 2000
Interaction	RegulatedBy Rv3911	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. N. Agarwal, SC. Woolwine et al. Characterization of the Mycobacterium tuberculosis sigma factor SigM by assessment of virulence and identification of SigM-dependent genes. Infect. Immun. 2007