Rv3540c - lipid transfer protein or keto acyl-CoA thiolase ltp2


Protein Domains

Gene Information
LocusRv3540c
Symbolltp2
Gene Namelipid transfer protein or keto acyl-CoA thiolase ltp2
Location3979499 - 3980659 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:1161 bp
Protein:387 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number20775
Related GenesMAP0527 MAV_0621 Mkms_4758 Mmcs_4672 MSMEG_5990 MT3644 MUL_4101 Mvan_5253 nfa4530
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
Search for regulators of Rv3540c
Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionRegulatory Rv3574activepriyadarshinipriyanka20012012-10-05
Co-expression (Functional linkage)
SL. Kendall,P. Burgess,R. Balhana,M. Withers,A. Ten Bokum,JS. Lott,C. Gao,I. Uhia Castro,NG. Stoker Cholesterol utilisation in mycobacteria is controlled by two TetR-type transcriptional regulators; kstR and kstR2. Microbiology (Reading, England) 2010
InteractionRegulatory Rv3574activepriyadarshinipriyanka20012012-10-05
Co-expression (Functional linkage)
SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
InteractionRegulatory Rv3574activeahal47892012-10-05
Co-expression (Functional linkage)
JC. Chang,MD. Miner,AK. Pandey,WP. Gill,NS. Harik,CM. Sassetti,DR. Sherman igr Genes and Mycobacterium tuberculosis cholesterol metabolism. J. Bacteriol. 2009
InteractionRegulatory Rv3574activeahal47892012-10-05
Co-expression (Functional linkage)
SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
InteractionRegulatory Rv3574activeahal47892012-10-05
Co-expression (Functional linkage)
SL. Kendall,P. Burgess,R. Balhana,M. Withers,A. Ten Bokum,JS. Lott,C. Gao,I. Uhia Castro,NG. Stoker Cholesterol utilisation in mycobacteria is controlled by two TetR-type transcriptional regulators; kstR and kstR2. Microbiology (Reading, England) 2010
InteractionRegulatory Rv3574activesourish102012-10-05
Co-expression (Functional linkage)
JC. Chang,MD. Miner,AK. Pandey,WP. Gill,NS. Harik,CM. Sassetti,DR. Sherman igr Genes and Mycobacterium tuberculosis cholesterol metabolism. J. Bacteriol. 2009
InteractionRegulatory Rv3574activesourish102012-10-05
Co-expression (Functional linkage)
SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
InteractionRegulatory Rv3574activesourish102012-10-05
Co-expression (Functional linkage)
SL. Kendall,P. Burgess,R. Balhana,M. Withers,A. Ten Bokum,JS. Lott,C. Gao,I. Uhia Castro,NG. Stoker Cholesterol utilisation in mycobacteria is controlled by two TetR-type transcriptional regulators; kstR and kstR2. Microbiology (Reading, England) 2010
InteractionRegulatedBy Rv3574activeyamir.moreno2012-10-05
Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support.
G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
TermEC:2.3.1.- Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. - NRactivensampson2012-03-05
Reaction blocked in mutant
authors,ST. Thomas,BC. VanderVen,DR. Sherman,DG. Russell,NS. Sampson Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism. J. Biol. Chem. 2011