Rv3546 - acetyl-CoA acetyltransferase fadA5
Protein Domains

Gene Information
LocusRv3546
SymbolfadA5
Gene Nameacetyl-CoA acetyltransferase fadA5
Location3985557 - 3986732 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:1176 bp
Protein:392 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number26379
Related GenesMAP0521c MAV_0615 Mkms_4764 Mmcs_4678 MSMEG_5996 MT3650 MUL_4107 Mvan_5259 nfa5170
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
Search for regulators of Rv3546
Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionRegulatory Rv3574activepriyadarshinipriyanka20012012-10-05
Co-expression (Functional linkage)
SL. Kendall,P. Burgess,R. Balhana,M. Withers,A. Ten Bokum,JS. Lott,C. Gao,I. Uhia Castro,NG. Stoker Cholesterol utilisation in mycobacteria is controlled by two TetR-type transcriptional regulators; kstR and kstR2. Microbiology (Reading, England) 2010
InteractionRegulatory Rv3574activepriyadarshinipriyanka20012012-10-05
Co-expression (Functional linkage)
SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
InteractionRegulatory Rv3574activejgalag2012-10-05
Co-expression (Functional linkage)
SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
InteractionRegulatory Rv3574activejgalag2012-10-05
Co-expression (Functional linkage)
NM. Nesbitt,X. Yang,P. Fontán,I. Kolesnikova,I. Smith,NS. Sampson,E. Dubnau A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol. Infect. Immun. 2010
TermEC:2.3.1.16 Acetyl-CoA C-acyltransferase. - NRactiveextern:JZUCKER2012-03-06
Inferred from mutant phenotype
NM. Nesbitt,X. Yang,P. Fontán,I. Kolesnikova,I. Smith,NS. Sampson,E. Dubnau A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol. Infect. Immun. 2010
TermEC:2.3.1.176 Propanoyl-CoA C-acyltransferase. - NRactivensampson2012-03-05
Reaction blocked in mutant
NM. Nesbitt,X. Yang,P. Fontán,I. Kolesnikova,I. Smith,NS. Sampson,E. Dubnau A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol. Infect. Immun. 2010
TermEC:2.3.1.16 Acetyl-CoA C-acyltransferase. - NRactivensampson2012-03-05
Reaction blocked in mutant
NM. Nesbitt,X. Yang,P. Fontán,I. Kolesnikova,I. Smith,NS. Sampson,E. Dubnau A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol. Infect. Immun. 2010
TermEC:2.3.1.176 Propanoyl-CoA C-acyltransferase. - NRactivensampson2012-03-05
Inferred from mutant phenotype
authors,JE. Griffin,JD. Gawronski,MA. Dejesus,TR. Ioerger,BJ. Akerley,CM. Sassetti High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog. 2011
TermEC:2.3.1.16 Acetyl-CoA C-acyltransferase. - NRactivensampson2012-03-05
Inferred from mutant phenotype
authors,JE. Griffin,JD. Gawronski,MA. Dejesus,TR. Ioerger,BJ. Akerley,CM. Sassetti High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog. 2011
Name3-Ketoacyl-CoA thiolaseactivecstolte2011-01-03
Nesbitt (2010) demonstrate that fadA5 is required for cholesterol metabolism and catalyzes the thiolysis of acetoacetyl-CoA. The authors propose that Rv3546 catalyzes the thiolysis step of beta-oxidation in the catabolism of the cholesterol side-chain.
SymbolFadA5activecstolte2011-01-03
Nesbitt (2010) demonstrate that fadA5 is required for cholesterol metabolism and catalyzes the thiolysis of acetoacetyl-CoA. The authors propose that Rv3546 catalyzes the thiolysis step of beta-oxidation in the catabolism of the cholesterol side-chain.
Name3-Ketoacyl-CoA thiolaseactivejgalag2010-09-02
Nesbitt (2010) demonstrate that fadA5 is required for cholesterol metabolism and catalyzes the thiolysis of acetoacetyl-CoA. The authors propose that Rv3546 catalyzes the thiolysis step of beta-oxidation in the catabolism of the cholesterol side-chain.
SymbolFadA5activejgalag2010-09-02
Nesbitt (2010) demonstrate that fadA5 is required for cholesterol metabolism and catalyzes the thiolysis of acetoacetyl-CoA. The authors propose that Rv3546 catalyzes the thiolysis step of beta-oxidation in the catabolism of the cholesterol side-chain.
Namethiolase
A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.
NM. Nesbitt,X. Yang,P. Fontán,I. Kolesnikova,I. Smith,NS. Sampson,E. Dubnau
Infect. Immun. 2010		activejgalag2010-07-29
Namethiolaseactivejgalag2010-07-29