Rv3581c - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF

Expression: Most Significant Conditions for Rv3581c

Protein Domains

Gene Information
Locus	Rv3581c
Symbol	ispF
Gene Name	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF
Location	4023868 - 4024347 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:480 bp Protein:160 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	1027
Related Genes	Acel_0081 BL0997 CE2520 cg2944 DIP1972 jk0309 MAP0477 MAV_0572 Mkms_4824 ML0322 Mmcs_4738 MSMEG_6075 MT3687 MUL_4157 Mvan_5339 nfa4370 PPA0354 SAV3968
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3581c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3581c Transcript 1
MNQLPRVGLGTDVHPIEPGRPCWLVGLLFPSADGCAGHSDGDVAVHALCDAVLSAAGLGD
IGEVFGVDDPRWQGVSGADMLRHVVVLITQHGYRVGNAVVQVIGNRPKIGWRRLEAQAVL
SRLLNAPVSVSATTTDGLGLTGRGEGLAAIATALVVSLR*

Genomic Sequence

>Rv3581c
GTGAATCAGCTGCCCCGCGTTGGTTTGGGGACCGATGTGCATCCGATCGAACCCGGACGT
CCGTGCTGGCTGGTAGGGTTGTTGTTCCCGAGCGCCGACGGTTGCGCGGGCCACTCCGAC
GGTGACGTGGCCGTTCATGCGCTGTGCGACGCGGTGCTGTCGGCCGCGGGGCTAGGCGAC
ATTGGCGAGGTGTTCGGCGTCGACGATCCCCGTTGGCAGGGTGTCAGTGGTGCCGACATG
TTGCGCCATGTCGTCGTCCTGATCACCCAGCATGGCTATCGGGTCGGCAACGCTGTGGTG
CAGGTGATCGGCAACCGACCGAAGATCGGTTGGCGCCGGCTCGAGGCGCAGGCGGTGCTG
TCACGTCTGCTCAACGCGCCGGTGTCGGTGTCGGCTACCACCACCGACGGGCTGGGCCTC
ACTGGCCGCGGCGAGGGCTTGGCCGCAATCGCTACGGCATTGGTGGTTTCGTTGCGGTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:MECDPS 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - IPI	active	njamshidi	2012-10-05
	PMID: 16321944 RK. Dhiman, ML. Schaeffer et al. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin. J. Bacteriol. 2005
Term	TBRXN:MECDPS 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - ISS	active	njamshidi	2012-10-05
	PMID: 16321944 RK. Dhiman, ML. Schaeffer et al. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin. J. Bacteriol. 2005
Name	methylerythritol 2,4-cyclodiphosphate synthase	active	mjackson	2012-10-05
	Non-mevalonate isopentenyl diphosphate synthesis
Term	EC:4.6.1.12 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,LE. Kemp,CS. Bond,WN. Hunter Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development. Proc. Natl. Acad. Sci. U.S.A. 2002